The behavioural, cognitive, and neural corollaries of blunted cardiovascular and cortisol reactions to acute psychological stress

Neuroscience & Biobehavioral Reviews, Journal Year: 2017, Volume and Issue: 77, P. 74 - 86

Published: Feb. 28, 2017

Language: Английский

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Cardiovascular and autonomic reactivity to psychological stress: Neurophysiological substrates and links to cardiovascular disease

Autonomic Neuroscience, Journal Year: 2017, Volume and Issue: 207, P. 2 - 9

Published: March 16, 2017

Language: Английский

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Adverse childhood experiences (ACEs) relate to blunted cardiovascular and cortisol reactivity to acute laboratory stress: A systematic review and meta-analysis

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 134, P. 104530 - 104530

Published: Jan. 11, 2022

Language: Английский

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Mental Stress and Cardiovascular Health—Part I

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(12), P. 3353 - 3353

Published: June 10, 2022

Epidemiological studies have shown that a substantial proportion of acute coronary events occur in individuals who lack the traditional high-risk cardiovascular (CV) profile. Mental stress is an emerging risk and prognostic factor for artery disease stroke, independently conventional factors. It associated with increased rate CV events. Acute mental may develop as result anger, fear, or job strain, well consequence earthquakes hurricanes. Chronic long-term repetitive exposure, such job-related stress, low socioeconomic status, financial problems, depression, type A D personality. While response to events, relationship chronic (CAD) mainly due acceleration atherosclerosis. Emotionally stressful stimuli are processed by network cortical subcortical brain regions, including prefrontal cortex, insula, amygdala, hypothalamus, hippocampus. This system involved interpretation relevance environmental stimuli, according individual’s memory, past experience, current context. The transduces cognitive process emotional into hemodynamic, neuroendocrine, immune changes, called fight flight response, through autonomic nervous hypothalamic–pituitary–adrenal axis. These changes induce transient myocardial ischemia, defined stress-induced ischemia (MSIMI) patients without significant obstruction. clinical consequences be angina, infarction, arrhythmias, left ventricular dysfunction. Although MSIMI increase mortality, it usually underestimated because arises pain most cases. occurs at lower levels cardiac work than exercise-induced suggesting impairment blood flow paradoxical vasoconstriction microvascular

Language: Английский

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Infralimbic prefrontal cortex structural and functional connectivity with the limbic forebrain: a combined viral genetic and optogenetic analysis

Brain Structure and Function, Journal Year: 2018, Volume and Issue: 224(1), P. 73 - 97

Published: Sept. 29, 2018

Language: Английский

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Host in the machine: A neurobiological perspective on psychological stress and cardiovascular disease.

American Psychologist, Journal Year: 2018, Volume and Issue: 73(8), P. 1031 - 1044

Published: Nov. 1, 2018

Psychological stress still attracts scientific, clinical, and public interest because of its suspected connection to health, particularly cardiovascular health. is thought arise from appraisal processes that imbue events contexts with personal significance threat-related meaning. These are also be instantiated in brain systems generate control peripheral physiological reactions through visceral motor (brain-to-body) sensory (body-to-brain) mechanisms. In the short term, may enable coping adaptive action. Among some individuals, however, patterning these predict or contribute pathology multiple organ systems, including system. At present, we lack a precise understanding link psychological appraisals patterns physiology physical This important: A mechanistic account how connects stressful experiences bodily changes health could help refine biomarkers risk targets for disease prevention intervention. We review research contributing this understanding, focusing on neurobiology reactivity suggest dysregulation during confer poor among vulnerable individuals. further describe need new interpretive frameworks markers brain-body behavioral medicine. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Language: Английский

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A Brain Phenotype for Stressor‐Evoked Blood Pressure Reactivity

Journal of the American Heart Association, Journal Year: 2017, Volume and Issue: 6(9)

Published: Aug. 24, 2017

Individuals who exhibit large-magnitude blood pressure (BP) reactions to acute psychological stressors are at risk for hypertension and premature death by cardiovascular disease. This study tested whether a multivariate pattern of stressor-evoked brain activity could reliably predict individual differences in BP reactivity, providing novel evidence candidate neurophysiological source stress-related risk.Community-dwelling adults (N=310; 30-51 years; 153 women) underwent functional magnetic resonance imaging with concurrent monitoring while completing standardized battery stressor tasks. Across individuals, the evoked an increase systolic diastolic relative nonstressor baseline period (M ∆systolic BP/∆diastolic BP=4.3/1.9 mm Hg [95% confidence interval=3.7-5.0/1.4-2.3 Hg]). Using cross-validation machine learning approaches, including dimensionality reduction linear shrinkage models, was identified training subsample (N=206). predicted both (r=0.32; P<0.005) (r=0.25; P<0.01) reactivity independent used testing replication (N=104). Brain areas encompassed that were strongly predictive included those implicated processing responding through autonomic pathways, medial prefrontal cortex, anterior cingulate insula.A may comprise phenotype partly accounts factor.

Language: Английский

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Neural Mechanisms Linking Emotion with Cardiovascular Disease

Current Cardiology Reports, Journal Year: 2018, Volume and Issue: 20(12)

Published: Oct. 11, 2018

Language: Английский

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Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction

Neuropharmacology, Journal Year: 2021, Volume and Issue: 188, P. 108519 - 108519

Published: March 11, 2021

Language: Английский

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Involvement of the brain–heart axis in the link between PTSD and cardiovascular disease

Depression and Anxiety, Journal Year: 2022, Volume and Issue: 39(10-11), P. 663 - 674

Published: June 16, 2022

Posttraumatic stress disorder (PTSD) has long been associated with a heightened risk of cardiovascular disease (CVD). A number mechanisms have implicated to underlie this brain-heart axis relationship, such as altered functioning the autonomic nervous system and increased systemic inflammation. While neural alterations repeatedly observed in PTSD, they are rarely considered PTSD-CVD link. The is pathway connecting frontal limbic brain regions brainstem periphery via it may be promising model for understanding CVD PTSD given its overlap deficits. We first provide summary primary association between CVD. then review relevance well findings from trials demonstrating that treatments effects on areas axis. Finally, we discuss sex considerations critical next step study determine if affect (e.g., stimulation improves function) also reduce

Language: Английский

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