Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 12, 2024
Abstract
While
neurosurgical
interventions
are
frequently
used
in
laboratory
mice,
refinement
efforts
to
optimize
analgesic
management
based
on
multimodal
approaches
appear
be
rather
limited.
Therefore,
we
compared
the
efficacy
and
tolerability
of
combinations
non-steroidal
anti-inflammatory
drug
carprofen,
a
sustained-release
formulation
opioid
buprenorphine,
local
anesthetic
bupivacaine
with
carprofen
monotherapy.
Female
male
C57BL/6J
mice
were
subjected
isoflurane
anesthesia
an
intracranial
electrode
implant
procedure.
Given
multidimensional
nature
postsurgical
pain
distress,
various
physiological,
behavioral,
biochemical
parameters
applied
for
their
assessment.
The
analysis
revealed
alterations
Neuro
scores,
home
cage
locomotion,
body
weight,
nest
building,
mouse
grimace
scales,
fecal
corticosterone
metabolites.
A
composite
measure
scheme
allowed
allocation
individual
severity
classes.
comparison
between
groups
failed
indicate
superiority
regimens
over
high-dose
NSAID
In
conclusion,
our
findings
confirmed
informative
value
assessment
distress
following
procedures
mice.
all
well
tolerated
control
data
suggest
that
total
load
should
carefully
considered
perioperative
management.
Future
studies
would
interest
assess
potential
synergies
lower
doses
carprofen.
Oxford University Press eBooks,
Journal Year:
2021,
Volume and Issue:
unknown
Published: Jan. 21, 2021
Abstract
This
book
is
intended
as
a
guide
for
anyone
who
interested
in
animals
and
how
their
welfare
can
be
assessed
scientifically.
It
addresses
the
question
of
why,
despite
growing
public
interest
are
treated,
it
has
proved
so
difficult
to
arrive
at
an
agreed
definition
what
‘animal
welfare’
then
provides
answer.
A
animal
‘health
having
they
want’
easily
understood
by
scientists
non-scientists
alike,
expresses
simple
words
underlies
many
existing
definitions
shows
evidence
we
need
collect
improve
practice.
Above
all,
puts
animal’s
own
point
view
heart
assessment
its
welfare.
The
also
helps
us
make
sense
long
often
confusing
list
measurements
that
now
use,
such
‘stress’
‘feel-good
hormones’,
expressive
sounds
gestures,
natural
behaviour,
cognitive
bias
stereotypies.
Animal
sentience
(conscious
feelings
pleasure
suffering)
discussed
context
our
current
knowledge
human
consciousness.
Finally,
highlights
some
key
ideas
relationship
between
science
ethics
closely
well-being
humans
linked
together.
Frontiers in Veterinary Science,
Journal Year:
2021,
Volume and Issue:
8
Published: Feb. 23, 2021
Virtual
fencing
involving
the
application
of
audio
cues
and
electrical
stimuli
is
being
commercially
developed
for
cattle.
has
potential
to
improve
productivity
through
optimized
pasture
management
utilization
by
grazing
animals.
The
virtual
initiates
public
concern
welfare
impacts
on
animals
due
aversive
nature
using
an
stimulus.
It
therefore
important
provide
assurance
livestock.
In
this
paper,
we
overview
assessment
validation
stages
which
could
be
applied
other
new
technologies
utilizing
novel
systems.
An
understanding
stress
measures
their
suitability
use
in
specific
contexts
discussed,
including
glucocorticoids
measure
both
acute
chronic
stress,
behavioral
responses
patterns
indicate
states.
importance
individual
differences
relation
learning
cognition
are
also
highlighted.
Together,
multi-disciplinary
approach
provides
a
tool
kit
that
may
some
systems
farm
Biological reviews/Biological reviews of the Cambridge Philosophical Society,
Journal Year:
2023,
Volume and Issue:
99(1), P. 1 - 22
Published: Aug. 27, 2023
ABSTRACT
Affective
states,
such
as
emotions,
are
presumably
widespread
across
the
animal
kingdom
because
of
adaptive
advantages
they
supposed
to
confer.
However,
study
affective
states
animals
has
thus
far
been
largely
restricted
enhancing
welfare
managed
by
humans
in
non‐natural
contexts.
Given
diversity
wild
and
variable
conditions
can
experience,
extending
studies
on
natural
that
most
experience
will
allow
us
broaden
deepen
our
general
understanding
welfare.
Yet,
this
same
makes
examining
highly
challenging.
There
is
therefore
a
need
for
unifying
theoretical
frameworks
methodological
approaches
guide
researchers
keen
engage
promising
research
area.
The
aim
article
help
advance
important
area
highlighting
central
relationship
between
physiology
rectify
its
apparent
oversight,
revealed
current
scientific
literature
animals.
Moreover,
emphasises
including
physiological
markers
assess
(e.g.
objectivity,
comparability,
condition
range,
temporality),
well
their
concomitant
limitations
only
access
peripheral
with
complex
relationships
states).
Best‐practice
recommendations
replication
multifactorial
approaches)
also
provided
be
used
effectively
appropriately
when
assessing
habitat.
This
review
seeks
provide
foundation
new
distinct
vast
applied
potential:
physiology.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(2), P. e0297358 - e0297358
Published: Feb. 7, 2024
Home
cage
aggression
in
group-housed
male
mice
is
a
major
welfare
concern
and
may
compromise
animal
research.
Conventional
cages
prevent
flight
or
retreat
from
sight,
increasing
the
risk
that
agonistic
encounters
will
result
injury.
Moreover,
depending
on
social
rank,
vary
their
phenotype,
these
effects
seem
highly
variable
dependent
context.
Interventions
reduce
aggression,
therefore,
not
only
injuries
stress,
but
also
variability
between
mates.
Here
we
housed
(Balb/c
SWISS,
group
sizes
of
three
five)
with
without
partial
dividers
for
two
months.
Mice
were
inspected
wounding
weekly
home
recorded
during
housing
after
6h
isolation
housing,
to
assess
assign
individual
ranks.
Fecal
boli
fur
collected
quantify
steroid
levels.
We
found
no
evidence
provision
improves
mice;
The
prevalence
levels
was
similar
conditions
reduced
Balb/c
strain.
However,
developed
less
despotic
hierarchies
had
more
stable
relationship
hormone
rank
type.
Therefore,
addition
play
role
stabilizing
ranks
modulating
activation
hypothalamic–pituitary–adrenal
(HPA)
hypothalamic-pituitary-gonadal
(HPG)
axes,
thus
reducing
phenotypic
different
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 12, 2024
Abstract
While
neurosurgical
interventions
are
frequently
used
in
laboratory
mice,
refinement
efforts
to
optimize
analgesic
management
based
on
multimodal
approaches
appear
be
rather
limited.
Therefore,
we
compared
the
efficacy
and
tolerability
of
combinations
non-steroidal
anti-inflammatory
drug
carprofen,
a
sustained-release
formulation
opioid
buprenorphine,
local
anesthetic
bupivacaine
with
carprofen
monotherapy.
Female
male
C57BL/6J
mice
were
subjected
isoflurane
anesthesia
an
intracranial
electrode
implant
procedure.
Given
multidimensional
nature
postsurgical
pain
distress,
various
physiological,
behavioral,
biochemical
parameters
applied
for
their
assessment.
The
analysis
revealed
alterations
Neuro
scores,
home
cage
locomotion,
body
weight,
nest
building,
mouse
grimace
scales,
fecal
corticosterone
metabolites.
A
composite
measure
scheme
allowed
allocation
individual
severity
classes.
comparison
between
groups
failed
indicate
superiority
regimens
over
high-dose
NSAID
In
conclusion,
our
findings
confirmed
informative
value
assessment
distress
following
procedures
mice.
all
well
tolerated
control
data
suggest
that
total
load
should
carefully
considered
perioperative
management.
Future
studies
would
interest
assess
potential
synergies
lower
doses
carprofen.