War and peace: exploring microbial defence systems as a source of new antimicrobial therapies

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

The WHO has compiled a list of pathogens that urgently require new antibiotics in response to the rising reports antibiotic resistance and diminished supply antibiotics. At top this is fluoroquinolone-resistant Salmonella typhi, Shigella spp. vancomycin-resistant Enterococcus faecium. Although these problems have been covered great detail by other contemporary reviews, there are still some fundamental gaps translation current knowledge infectious process molecular ecology production into sustainable protocol for treatment pathogenic diseases. Therefore, narrative review we briefly discuss newly approved antimicrobial drugs (since 2014) could help alleviate burden multiresistant listed on priority list. Being conscious such treatments may eventually run risk future cycles resistance, also how understandings disease can be harnessed create more solution

Language: Английский

---

Repeated exposure to antibiotics exhibits anxiety-like behaviors with a reduction in neurogenesis in the ventral hippocampus of dentate gyrus

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138131 - 138131

Published: Jan. 1, 2025

Language: Английский

---

Sequential exposure to multiple antibiotics depleted glutathione in hepatocytes, disrupted hematological profile, and inflammatory responses in a mouse model

Comparative Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

---

The Impact of Antibiotic Therapy on Intestinal Microbiota: Dysbiosis, Antibiotic Resistance, and Restoration Strategies

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 371 - 371

Published: April 3, 2025

The human gut microbiota—an intricate and dynamic ecosystem—plays a pivotal role in metabolic regulation, immune modulation, the maintenance of intestinal barrier integrity. Although antibiotic therapy is indispensable for managing bacterial infections, it profoundly disrupts microbial communities. Such dysbiosis typified by diminished diversity shifts community structure, especially among beneficial genera (e.g., Bifidobacterium Eubacterium), fosters antibiotic-resistant strains horizontal transfer resistance genes. These alterations compromise colonization resistance, increase permeability, amplify susceptibility to opportunistic pathogens like Clostridioides difficile. Beyond gastrointestinal disorders, emerging evidence associates with systemic conditions, including chronic inflammation, syndrome, neurodegenerative diseases, underscoring relevance microbiota–gut–brain axis. recovery pre-existing communities post-antibiotic highly variable, influenced drug spectrum, dosage, treatment duration. Innovative interventions—such as fecal microbiota transplantation (FMT), probiotics, synbiotics, precision microbiome therapeutics—have shown promise counteracting mitigating its adverse effects. therapies align closely stewardship programs aimed at minimizing unnecessary use preserve curtail spread multidrug-resistant organisms. This review emphasizes pressing need microbiota-centered strategies optimize administration, promote long-term health resilience, alleviate disease burden associated antibiotic-induced dysbiosis.

Language: Английский

---

Effects of Early-life Antibiotic Use on Emotional and Behavioral Development Trajectories in Preschool Children

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 186, P. 244 - 251

Published: April 17, 2025

Language: Английский

---