Niosomal nanocarriers loaded with artemisinin has potential to enhance the functional characteristics of cryo-preserved equine spermatozoa DOI
Azam Abbasi,

Houshang Nouri,

F. Samadi

et al.

Animal Reproduction Science, Journal Year: 2024, Volume and Issue: 272, P. 107653 - 107653

Published: Nov. 26, 2024

Language: Английский

Network pharmacological mechanism and molecular experimental validation of artemisinin in the treatment of lung adenocarcinoma DOI
Zhimin Lu,

Jialu Jiang,

Xuming Yao

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 495, P. 117226 - 117226

Published: Jan. 7, 2025

Language: Английский

Citations

0
Methyl jasmonate elicitation improved growth, antioxidant enzymes, and artemisinin content in in vitro callus cultures of Artemisia maritima L. DOI

Neelofer Nabi,

Seema Singh, Peer Saffeullah

et al.

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 177, P. 729 - 741

Published: Jan. 10, 2025

Language: Английский

Citations

0
Betulonic acid: A review on its sources, biological activities, and molecular mechanisms DOI

Shengying Lou,

Chunyan Dai,

Yuhua Wu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177518 - 177518

Published: March 1, 2025

Language: Английский

Citations

0
Artemisinin and Its Derivatives: Promising Therapeutic Agents for Age-Related Macular Degeneration DOI Creative Commons
Chun Liu, Xiao‐Qin Liu, Junguo Duan

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 535 - 535

Published: April 6, 2025

Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in older adults. Its pathogenesis involves multiple factors, including aging, environmental influences, genetic predisposition, oxidative stress, metabolic dysfunction, immune dysregulation. Currently, AMD treatment focuses primarily on wet AMD, managed through repeated intravitreal injections anti-vascular endothelial growth factor (VEGF) therapies. While anti-VEGF agents represent major breakthrough care, may lead to incomplete responses or resistance some patients, carry risk progressive fibrosis. Artemisinin (ART) its derivatives, originally developed as antimalarial drugs, exhibit broad spectrum pleiotropic activities beyond their established use, anti-inflammatory, anti-angiogenic, antioxidant, anti-fibrotic, mitochondrial regulatory, lipid metabolic, immunosuppressive effects. These properties position ART promising therapeutic candidate for AMD. A growing interest ART-based therapies has emerged recent years, with numerous studies demonstrating potential benefits. However, no comprehensive review systematically summarized the specific roles derivatives treatment. This paper aims fill knowledge gap by synthesizing efficacy molecular mechanisms thereby providing foundation future investigations.

Language: Английский

Citations

0
Dihydroartemisinin inhibited vasculogenic mimicry in gastric cancer through the FGF2/FGFR1 signaling pathway DOI Creative Commons
Huina Wang,

Qingzhu Ding,

Haihua Zhou

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155962 - 155962

Published: Aug. 15, 2024

Vasculogenic mimicry (VM) is a novel model for supplying blood to multiple tumors, including gastric cancer (GC), and potential target its treatment. Dihydroartemisinin (DHA) natural antitumor substance that inhibits the progression of tumors in many ways. The research aimed evaluate impact DHA on VM formation mechanisms. IC50 DHA, DHA's effect proliferation, invasion, migration GC cells both cell animal models were determined through wound healing, MTT, EdU, colony formation, Transwell assays. Genomics was employed identify genes related inhibition analyze their relationship formation. qRT‒PCR western blot (WB) analysis carried out changes protein mRNA levels after treatment VM-associated biomarkers blocking gene-related pathways. mechanism by which elucidated vivo. reduced inhibited A total 220 DEGs identified DHA-treated HGC-27 cells. Among 146 downregulated genes, fibroblast growth Factor 2 (FGF2) most closely associated with angiogenesis VM. level FGF2 tissues markedly greater than lacking tissues. Treatment or FGFR1 blockade suppressed VM-related biomarker proteins. tumor reducing xenograft mouse models. Per our knowledge, this first study demonstrate inhibitory VM, providing strategy GC.

Language: Английский

Citations

3
Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma DOI Creative Commons
Xiaodong Wang, Fancheng Meng, Jingxin Mao

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: July 16, 2024

Hepatocellular carcinoma is one of the common malignant tumors digestive tract, which seriously threatens life patients due to its high incidence rate, strong invasion, metastasis, and prognosis. At present, main methods for preventing treating HCC include medication, surgery, intervention, but frequently encounter with specific adverse reactions or side effects. Many Traditional Chinese medicine can improve liver function, reduce cancer recurrence have unique advantages in treatment because their acting mode multi-target, multi-pathway, multi-component, multi-level. Sesquiterpenoids, a class natural products are widely present nature exhibit good anti-tumor activity, many them possess potential HCC. This article reviewed activities, resources, pharmacological mechanism sesquiterpenoids against HCC, providing theoretical basis prevention comprehensive understanding development new clinical drugs.

Language: Английский

Citations

2
Sesquiterpenes from the aerial parts of Artemisia vachanica Krasch. ex Poljakov and their anti-inflammatory and anti-diabetic activities DOI
Parviz Sukhrobov, Jun Li, Liu Liu

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 230, P. 114317 - 114317

Published: Nov. 7, 2024

Language: Английский

Citations

2
Artemisinin May Disrupt Hyphae Formation by Suppressing Biofilm-Related Genes of Candida albicans: In Vitro and In Silico Approaches DOI Creative Commons
Esra Şumlu, Merve Aydın, Emine Nedime Korucu

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(4), P. 310 - 310

Published: March 28, 2024

This study aimed to assess the antifungal and antibiofilm efficacy of artemisinin against Candida (C.) species, analyze its impact on gene expression levels within C. albicans biofilms, investigate molecular interactions through docking. The a variety including fluconazole-resistant -susceptible was evaluated by microdilution method. effect biofilm formation investigated MTT FESEM. mRNA genes related analyzed qRT-PCR. In addition, docking analysis used understand interaction between at level with RAS1-cAMP-EFG1 EFG1-regulated genes. Artemisinin showed higher sensitivity non-albicans strains. Furthermore, strongly inhibitory biofilms 640 µg/mL. downregulated adhesion-related ALS3, HWP1, ECE1, hyphal development UME6 HGC1, CAMP-dependent protein kinase regulators CYR1, RAS1, EFG1. revealed that EFG1 had highest affinity, followed UME6. FESEM fluconazole- artemisinin-treated groups exhibited reduced network, unusual surface bulges, pores cell surfaces. Our suggests may have potential remarkable activity significantly suppressing adhesion key proteins involved in formation, such as

Language: Английский

Citations

1
Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities DOI Creative Commons

Wen-Zhe Nie,

Yalan Wang,

Xinlu Tian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4193 - 4193

Published: Sept. 4, 2024

The emergence of natural products has provided extremely valuable references for the treatment various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is most abundant member cucurbitin family exhibits wide range biological activities, including anti-inflammatory, anti-cancer, even agricultural applications. Due to its high toxicity narrow therapeutic window, structural modification dosage form development are necessary address these issues with cucurbitacin B. This paper reviews recent research progress in pharmacological action, modification, application review aims enhance understanding advancements this field provide constructive suggestions further on

Language: Английский

Citations

1
Molecular dynamics insight of interaction between Artemisinin and its derivatives and the cancer cell membrane DOI Creative Commons

Samaneh Boroomand,

Delara Mohammad-Aghaie,

Fatemeh Mohammadpour

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract In the present study, molecular dynamics simulation approach has been utilized to investigate effectiveness of four molecules, including Artemisinin, a natural product, and its derivatives Dihydroartemisinin, Artesunate, Artemisone, on cancer cell membrane model. Performed simulations predicted that Dihydroartemisinin Artemisone form stronger hydrogen bonds with membrane, exhibit higher mobility, have longer lifetime at water-membrane interface. molecules could penetrate hydrophobic part lipid’s tail which led fluidity membrane. These two compounds were able exert greatest effect change properties characteristics model while showing anti-cancer effects than other compounds. The outcomes predictions found agree results experimental studies. There is noticeable difference in way enter compared Artemisinin Artesunate. former from functional group side into latter pass it peroxide ring side.

Language: Английский

Citations

0