Molecules,
Journal Year:
2024,
Volume and Issue:
30(1), P. 118 - 118
Published: Dec. 31, 2024
Aconitum
stands
out
among
the
Ranunculaceae
family
for
its
notable
use
as
an
ornamental
and
medicinal
plant.
Diterpenoid
alkaloids
(DAs),
characteristic
compounds
of
Aconitum,
have
been
found
to
effective
analgesic
anti-inflammatory
effects.
Despite
their
potential,
toxicity
most
DAs
restricts
direct
in
traditional
medicine,
necessitating
complex
processing
before
use.
The
high-throughput
omics
allows
investigation
plant
genetics,
gene
regulation,
metabolic
pathways,
growth
development.
We
collected
comprehensive
information
on
studies
plants,
encompassing
genomics,
transcriptomics,
metabolomics,
proteomics,
microbiomics,
from
internationally
recognized
electronic
scientific
databases
such
Web
Science,
PubMed,
CNKI.
In
light
this,
we
identified
research
gaps
proposed
potential
areas
key
objectives
research,
aiming
establish
a
framework
quality
improvement,
molecular
breeding,
deeper
understanding
specialized
metabolite
production
plants.
Horticulturae,
Journal Year:
2024,
Volume and Issue:
10(8), P. 887 - 887
Published: Aug. 21, 2024
Isopentenyl
diphosphate
isomerase
(IPI)
is
a
key
enzyme
in
the
synthesis
of
isoprenoids.
In
this
paper,
vivo
biological
activity
IPI
gene
from
Fritillaria
unibracteata
(FuIPI)
was
investigated.
Combining
color
complementation
experiment
with
High-Performance
Liquid
Chromatography
analysis
showed
that
FuIPI
could
accumulate
β-carotene
Escherichia
coli,
and
Glu190
identified
as
residue
for
its
catalytic
activity.
Bioinformatics
together
subcellular
localization
indicated
protein
localized
chloroplasts.
Compared
wild-type
Arabidopsis
thaliana,
transgenic
plants
had
higher
abscisic
acid
content
strengthening
tolerance
to
drought
salt
stress.
Overall,
these
results
substantial
vivo,
hopefully
laying
foundation
further
research
application
liliaceous
ornamental
medicinal
plants.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 20, 2024
Abstract
Background
Using
network
pharmacology
and
molecular
docking
methods,
this
study
explores
the
mechanism
of
action
Fritillaria
Taibaiensis
(Taibai
Beimu,
TB)
in
relieving
cough,
asthma,
phlegm,
preliminarily
verifies
relevant
pathways
through
animal
experiments.
Methods
traditional
Chinese
medicine
database
to
screen
main
components
targets,
obtaining
disease
targets
database,
repeated
were
summarized
deleted
before
being
imported
into
Cytoscape
software
construct
a
network;
analyze
protein-protein
interactions
intersecting
obtain
core
targets.
Perform
enrichment
analysis
on
"drug
component
target
pathway
disease"
Simultaneously,
Maestro
was
used
for
verify
binding
ability
active
ingredient
target.
Animal
experiments
conducted
cough
stopping,
asthma
relieving,
expectorant
effects
TB;
Western
blot
verification
its
effect
expression
level
proteins.
Results
9
ingredients
152
screened,
KEGG
predicted
that
drugs
mainly
exert
their
signaling
such
as
NF-κB,
HIF1,
FoxO.
Molecular
showed
93.3%
activity
less
than
−
5kcal/mol,
indicating
good
affinity.
The
low-dose
TB
significantly
reduced
number
coughs
mice
within
3
minutes,
while
high-dose
group
significant
extension
latent
period
wheezing.
excretion
phenol
red
trachea
increased
group.
Compared
with
normal
group,
protein
levels
TLR4,
MyD88
model
(P
<
0.001,
P
0.01);
compared
decreased
0.01,
0.05);
pentosidine
there
no
differences
among
treatment
groups.
Conclusions
Through
experimental
analysis,
it
can
be
found
inhibits
inflammatory
response
mice,
may
related
inhibition
TLR4/NF-κB
activation.
Environmental Research,
Journal Year:
2024,
Volume and Issue:
263, P. 120131 - 120131
Published: Oct. 9, 2024
Air
pollution
is
a
well-established
risk
factor
for
several
adverse
health
outcomes,
but
the
specific
molecular
mechanisms,
particularly
those
involving
metabolic
processes,
remain
incompletely
understood.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(11), P. 590 - 590
Published: Oct. 31, 2024
P.Y.
Li
is
a
valuable
traditional
Chinese
medicinal
herb
that
utilizes
bulbs
as
medicine,
which
contain
multiple
alkaloids.
Biomass,
sustainable
resource,
has
promising
applications
in
energy,
environmental,
and
biomedical
fields.
Recently,
the
biosynthesis
regulatory
mechanisms
of
main
biomass
components
have
become
prominent
research
topic.
Molecules,
Journal Year:
2024,
Volume and Issue:
30(1), P. 118 - 118
Published: Dec. 31, 2024
Aconitum
stands
out
among
the
Ranunculaceae
family
for
its
notable
use
as
an
ornamental
and
medicinal
plant.
Diterpenoid
alkaloids
(DAs),
characteristic
compounds
of
Aconitum,
have
been
found
to
effective
analgesic
anti-inflammatory
effects.
Despite
their
potential,
toxicity
most
DAs
restricts
direct
in
traditional
medicine,
necessitating
complex
processing
before
use.
The
high-throughput
omics
allows
investigation
plant
genetics,
gene
regulation,
metabolic
pathways,
growth
development.
We
collected
comprehensive
information
on
studies
plants,
encompassing
genomics,
transcriptomics,
metabolomics,
proteomics,
microbiomics,
from
internationally
recognized
electronic
scientific
databases
such
Web
Science,
PubMed,
CNKI.
In
light
this,
we
identified
research
gaps
proposed
potential
areas
key
objectives
research,
aiming
establish
a
framework
quality
improvement,
molecular
breeding,
deeper
understanding
specialized
metabolite
production
plants.
