Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(39)
Published: July 9, 2024
Abstract
On
the
basis
of
a
novel
ynol‐diene
cyclization
developed
as
rapid
access
to
tropone
unit,
first
divergent
strategy
17‐
nor
‐cephalotane
diterpenoids
has
been
successfully
established.
Combining
with
bioinspired
stereoselective
dual
hydrogenation,
total
synthesis
(+)‐3‐deoxyfortalpinoid
F,
(+)‐harringtonolide,
(−)‐fortalpinoids
M/N/P,
and
analog
(−)‐20‐deoxocephinoid
P
have
achieved
in
14–17
linear
longest
steps
starting
from
commercially
available
materials.
JACS Au,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Herein,
we
present
a
unified
strategy
for
the
total
synthesis
of
benzenoid
and
troponoid
Cephalotaxus
diterpenoids,
specifically
cephanolides
A
B
(benzenoids)
harringtonolide
cephinoid
H
(troponoids),
in
13
to
19
longest
linear
steps.
This
relies
on
palladium-catalyzed
Csp2–Csp3
cross–coupling
followed
by
an
intramolecular
doubly
electron-deficient
Diels–Alder
reaction
establish
core
skeleton
complete
benzenoids.
late-stage
regioselective
phenol-to-tropone
ring
expansion
was
developed
convert
benzenoids
corresponding
congeners.
work
provides
regiocontrolled
approach
achieving
synthetic
connectivity
between
diterpenoids.
Natural Product Reports,
Journal Year:
2024,
Volume and Issue:
41(7), P. 1152 - 1179
Published: Jan. 1, 2024
Covering:
up
to
the
end
of
2023Cephalotane
diterpenoids
are
a
unique
class
natural
products
exclusive
genus
Cephalotaxus,
featuring
rigid
7,6,5,6-fused
tetracyclic
architecture.
The
study
cephalotanes
dates
back
1970s,
when
harringtonolide
(1),
Cephalotaxus
troponoid
with
peculiar
norditerpenoid
carbon
skeleton,
was
first
discovered.
In
recent
years,
prototype
C20
proposed
as
cephalotane
were
disclosed,
which
triggered
intense
studies
on
this
diterpenoid
family.
To
date,
cumulative
total
105
great
structural
diversity
and
biological
importance
have
been
isolated.
addition,
significant
advances
made
in
field
synthesis
biosynthesis
years.
This
review
provides
complete
overview
chemical
structures,
bioactivities,
biosynthetic
aspects,
completed
all
isolated
diterpenoids,
will
help
guide
future
research
compounds.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 23, 2024
On
the
basis
of
a
novel
ynol-diene
cyclization
developed
as
rapid
access
to
tropone
unit,
first
divergent
strategy
17-nor-cephalotane
diterpenoids
has
been
successfully
established.
Combining
with
bioinspired
stereoselective
dual
hydrogenation,
total
synthesis
(+)-3-deoxyfortalpinoid
F,
(+)-harringtonolide,
(-)-fortalpinoids
M/N/P,
and
analog
(-)-20-deoxocephinoid
P
have
achieved
in
14-17
linear
longest
steps
starting
from
commercially
available
materials.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
90(4), P. 1697 - 1705
Published: Jan. 21, 2025
Three
seco-norabietane
diterpenoids,
salvicsites
A-C
(1-3),
along
with
two
known
compounds,
were
isolated
from
the
roots
and
rhizomes
of
Salvia
castanea
Diels
f.
tomentosa
Stib.
Salvicsite
A
(1)
represents
an
unprecedented
structural
combination,
featuring
eight-membered
α-methyl-α,β-unsaturated
lactone
ring
a
five-membered
α,β-unsaturated
ring,
based
on
6/6/5/8
system.
Their
structures
elucidated
through
comprehensive
spectroscopic
analyses,
X-ray
crystallography,
quantum
chemical
calculations.
Putative
biosynthetic
pathways
1-3
proposed,
compound
5
being
plausible
biogenetic
precursor.
The
AChE
inhibition
assay
demonstrated
that
salvicsite
exhibited
notable
inhibitory
effect
against
AChE,
IC50
value
9.56
±
1.05
μM.
Enzymatic
kinetic
studies
indicated
acted
as
mixed-type
inhibitor,
its
binding
mode
was
explored
molecular
docking.
results
cytotoxic
activity
only
activity.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2250 - 2250
Published: March 3, 2025
Natural
products,
especially
specific
metabolites
found
in
many
medicinal
plants,
exhibit
extensive
therapeutic
potential
due
to
their
diverse
biological
characteristics.
Among
these
compounds,
diterpenes
stand
out
for
active
principles
described
phytochemical
studies.
Diterpenes
immunomodulatory
effects
by
influencing
the
production
of
cytokines
and
other
signaling
molecules
involved
immune
response.
These
actions
contribute
achieving
a
more
balanced
profile.
The
ability
selectively
harmoniously
modulate
response
positions
compounds
derived
from
natural
products
is
promising
research
field
development
therapies.
Due
broad
activities
diterpenes,
use
molecular
docking
emerges
as
relevant
tool
quantitative
screening
large
number
substances.
This
review
comprehensively
examines
pharmacological
modulating
system.
It
highlights
existing
experimental
evidence
supporting
efficacy
safety
treatment
dysfunctions.
Ultimately,
this
aims
new
strategies
field.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
An
efficient
visible-light-driven
method
for
achieving
α-site-selective
C–H
alkylation
of
tropones
was
developed.
It
applied
to
transform
fortunolide
A
into
cephafortunoids
and
B,
marking
the
first
synthesis
C
20
Cephalotaxus
troponoids.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: May 20, 2025
Cephalotane
diterpenoids,
featuring
unique
and
complicated
carbon
skeletons
remarkable
antitumor
activities
from
the
Cephalotaxus
genus,
have
been
gaining
increasing
attention.
Herein,
we
report
asymmetric
divergent
total
synthesis
of
benzenoid
cephalotane-type
diterpenoids
containing
identical
6/6/6/5
tetracyclic
bridged
δ-lactone
skeleton
with
different
oxidation
states.
A
cascade
C(sp2)
C(sp3)-H
activation
has
developed
to
efficiently
prepare
characteristic
synthetically
challenging
through
a
pivotal
palladium/NBE-cocatalyzed
process.
The
feature
this
strategy
is
construction
three
C-C
bonds
(two
C(sp2)-C(sp3)
one
C(sp3)-C(sp3)
bond)
formation
two
cycles
chiral
centers
in
single
step.
application
method
for
rapid
assembly
demonstrated
concise
cephanolides
A-D
(1-4)
ceforalide
B
(5)
via
late-stage
modification.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(10), P. 2359 - 2359
Published: May 16, 2024
The
increasing
prevalence
of
autoimmune
diseases
globally
has
prompted
extensive
research
and
the
development
immunosuppressants.
Currently,
immunosuppressive
drugs
such
as
cyclosporine,
rapamycin,
tacrolimus
have
been
utilized
in
clinical
practice.
However,
long-term
use
these
may
lead
to
a
series
adverse
effects.
Therefore,
there
is
an
urgent
need
explore
novel
drug
candidates
for
treating
diseases.
This
review
aims
find
potential
candidate
molecules
natural
compounds
derived
from
plants,
animals,
fungi
over
past
decade.
These
include
terpenoids,
alkaloids,
phenolic
compounds,
flavonoids,
others.
Among
them,
49,
151,
173,
200,
204,
247
excellent
activity;
their
IC50
were
less
than
1
μM.
A
total
109
good
activity,
with
ranging
10
active
high
medicinal
potential.
names,
sources,
structures,
structure-activity
relationship
summarized
analyzed.
