Traditional Chinese medicine preparation Shuang-Huang-Lian in the treatment of influenza: a review

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119704 - 119704

Published: March 1, 2025

Language: Английский

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Phillyrin from Forsythia suspensa suppresses the proliferation, angiogenesis, and metastasis of colorectal cancer via targeting CD147

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119759 - 119759

Published: April 1, 2025

Language: Английский

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Forsythoside a as a potential therapeutic agent for non-alcoholic fatty liver disease: from target identification to in vitro and in vivo validation

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 26, 2025

Non-alcoholic fatty liver disease (NAFLD) is a long-term metabolic condition marked by unusual fat buildup in the liver, with an increasing occurrence worldwide. Forsythoside A (FA), bioactive component of Forsythia suspensa, has anti-inflammatory, antioxidative, and hepatoprotective effects. This study investigates mechanisms which FA may treat NAFLD. Using bioinformatics tools, 35 potential targets were identified, protein-protein interaction network was constructed. KEGG GO enrichment analyses highlighted important pathways associated The effects confirmed using both vitro vivo NAFLD models. Matrix Metalloproteinase 9 (MMP9), Tumour Necrosis Factor Alpha (TNFɑ), identified as core targets. analysis showed that affects metabolic, TNF signalling, insulin resistance pathways. In vivo, reduced lipid accumulation modulated TNFɑ, MMP9, ALB expression. modulating TNFɑ/MMP9/ALB pathway, providing new therapeutic insights for treatment.

Language: Английский

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Maternal supplementation of Lonicera flos and Scutellaria Baicalensis mixed extracts improve reproduction performance and metabolic health through modulating gut microbiota during pregnancy

BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)

Published: May 1, 2025

Language: Английский

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Synergistic effects of dietary Forsythia suspensa extract and Astragalus membranaceus polysaccharides on growth enhancement, antioxidant boost, and inflammation alleviation in juvenile Larimichthys crocea

Aquaculture, Journal Year: 2024, Volume and Issue: unknown, P. 742029 - 742029

Published: Dec. 1, 2024

Language: Английский

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Effect of natural products on host cell autophagy induced by Influenza A virus infection

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 30, 2024

Influenza A virus (IAV) can cause seasonal epidemics and global pandemics, posing serious threats to public health, making a deeper understanding of its biological characteristics effective countermeasure strategies essential. Autophagy not only maintains cellular homeostasis but also plays an important role in host defense against IAV infection. However, the relationship between autophagy is complex, antiviral drugs are yet available. Natural products have shown excellent potential disease control due their diversity multi-targeting. This review focuses on discusses targeting autophagic pathways for development new therapies. Particularly, use plant extracts as modulators has garnered attention non-toxic nature cost-effectiveness, which provides strong support future that help inhibit viral infections slow down progression.

Language: Английский

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C17-Labdane diterpenoid alkaloids bearing a rare skeleton with anti-inflammatory and anti-oxidant activities from Forsythia suspensa

Fitoterapia, Journal Year: 2024, Volume and Issue: 180, P. 106345 - 106345

Published: Dec. 10, 2024

Language: Английский

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Pulmonary delivery of forsythin-phospholipid complexes improves the lung anti-inflammatory efficacy in mice by enhancing dissolution and lung tissue affinity

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114305 - 114305

Published: Oct. 8, 2024

Language: Английский

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