Artemyriantholidimers A-G, undescribed guaiane-type sesquiterpenoid dimers from Artemisia myriantha and their antihepatoma activities

Phytochemistry, Journal Year: 2025, Volume and Issue: 233, P. 114409 - 114409

Published: Jan. 16, 2025

Language: Английский

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Artemselenoids A−H, eight guaiane-type sesquiterpenoid dimers from Artemisia selengensis and their antihepatoma activities

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Eight undescribed guaiane-type sesquiterpenoid dimers (GSDs), artemselenoids A-H (1-8), together with nine known GSDs (9-17), were isolated from Artemisia selengensis. Their structures and absolute configurations determined through comprehensive spectral analyses, theoretical ECD calculations, NMR computations. Chemically, compound 1 represented the first example of two guaianolide lactone units dimerizing unprecedented C-3-C-11' C-4-C-13' bonds via a [2 + 2] cycloaddition reaction producing structurally unique 5,4 spirocyclic system; compounds 2-8 biogenetically formed [4 reaction. Specifically, 2-7 connected by C-1-C-13' C-4-C-11' bonds, while 8 was linked bonds. Antihepatoma assays indicated that most active 3 demonstrated significant inhibitory effects on three hepatoma cell lines, IC50 values 7.4 5.1 μM (HepG2), 5.9 8.6 (Huh7), 20.9 9.6 (SK-Hep-1), which equal to those positive control sorafenib.

Language: Английский

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Artemiyrianins A-H, guaiane-type sesquiterpenoids from Artemisia myriantha var. pleiocephala and their antihepatoma activity

Fitoterapia, Journal Year: 2025, Volume and Issue: 183, P. 106527 - 106527

Published: April 12, 2025

Language: Английский

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Artemsieverlides A–M, diverse sesquiterpenoid dimers with antihepatic fibrosis activity isolated from Artemisia sieversiana based on molecular networking

Phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 114518 - 114518

Published: April 1, 2025

Language: Английский

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Artemordosins A−L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica

Phytochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 114374 - 114374

Published: Dec. 1, 2024

Language: Английский

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