Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A–O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the ‘vulnerable’ conifer and their inhibitory effects on ATP-citrate lyase

Phytochemistry, Journal Year: 2024, Volume and Issue: 226, P. 114221 - 114221

Published: July 11, 2024

Language: Английский

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Antimicrobial and Anticancer Potential of Polyketides Isolated from the Caribbean Marine Sponge Plakortis halichondrioides

Drugs and Drug Candidates, Journal Year: 2025, Volume and Issue: 4(1), P. 6 - 6

Published: Feb. 15, 2025

Background/Objectives: The marine sponge Plakortis halichondrioides is notable for its capacity to accumulate a large array of secondary metabolites. present research aims at discovering new metabolites from P. with potential applications in medicine. Methods: Plakortilactone (1) and seco-plakortide F acid (2), two polyketides, along known manadodioxan D (3), 13-oxo-plakortide (4), plakortide (5), E (6), were isolated halichondrioides. We achieved the structural elucidation 1 2 using modern spectroscopic methods. relative stereochemistry was proposed on basis 1D- 2D-NMR data combination molecular modeling studies. Additionally, absolute configuration established through chemical correlation 5. screened some compounds against malaria parasite Plasmodium falciparum 3D7 non-resistant (wild-type resistant) strain, tuberculosis bacterium Mycobacterium tuberculosis, prostate cancer cell line DU-145, melanoma A-2058. Results: minimal activity detected these cells. In contrast, 3 4 displayed DU-145 cells IC50 values 1.6 µg/mL 4.5 µg/mL, respectively, A-2058 IC50s 2.6 7.7 respectively. antiplasmodial assay appeared more active (IC50 = 1.7 µg/mL) than 3.1 µg/mL). Meanwhile, only moderate 39.3 antimycobacterial exhibited inhibition (MIC 75.1 1:1 mixture demonstrated higher 26.3 Conclusions: biological together ADMET predictions indicated favorable pharmacokinetic properties 3.

Language: Английский

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Mulberry Diels-Alder-type adducts and other phenolic compounds with ATP-citrate lyase inhibitory effects from Morus alba and their chemotaxonomic significance

Biochemical Systematics and Ecology, Journal Year: 2025, Volume and Issue: 121, P. 104992 - 104992

Published: March 1, 2025

Language: Английский

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Diterpene-phenylpropanoid hybrids and structurally diverse diterpenoid monomers from the endangered conifer Podocarpus annamiensis and their bioactivities

Phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 114533 - 114533

Published: May 1, 2025

Language: Английский

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Undescribed polyketides from endophytes associated with the critically endangered conifer Abies beshanzuensis

Fitoterapia, Journal Year: 2024, Volume and Issue: 177, P. 106104 - 106104

Published: June 29, 2024

Language: Английский

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Pentacyclic triterpenoids as potential ACL inhibitors from the rare medicinal plant Semiliquidambar cathayensis

Fitoterapia, Journal Year: 2024, Volume and Issue: 176, P. 106018 - 106018

Published: May 12, 2024

Language: Английский

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