The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 522 - 522

Published: Jan. 8, 2025

The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been subject thousands studies over 125 clinical trials. many mechanisms action mammalian systems have extensively documented. is most potent naturally occurring inducer Keap1/Nrf2 pathway, which well-known for upregulation antioxidant detoxification activation pathways resulting inhibition inflammation. Much this regulation involves various hormonal axes body. However, influence on hormone-mediated health conditions remains unexplored recent scholarly reviews. This review aims to address gap by exploring these interactions, with a focus wellness issues specific both females males.

Language: Английский

CO-Sprout—A Pilot Double-Blinded Placebo-Controlled Randomised Trial of Broccoli Sprout Powder Supplementation for Pregnant Women with COVID-19 on the Duration of COVID-19-Associated Symptoms: Study Protocol

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3980 - 3980

Published: Sept. 14, 2023

Since its discovery in late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been estimated to be responsible for at least 769.3 million infections and over 6.95 deaths. Despite significant global vaccination efforts, there are limited therapies that considered safe effective use management of COVID-19 during pregnancy despite common knowledge pregnant patients have a much higher risk adverse outcomes. A bioactive compound found broccoli sprout—sulforaphane—is potent inducer phase-II detoxification enzymes promoting series potentially beneficial effects notably as an antioxidant, anti-inflammatory, anti-viral. pilot, double-blinded, placebo-controlled randomised trial is conducted Melbourne, Australia, across both public private hospital sectors. We will assess commercially available sprout extract women between 20+0 36+0 weeks gestation with SARS-CoV-2 infection investigate (i) duration associated symptoms, (ii) maternal neonatal outcomes, (iii) biomarkers inflammation. plan enrol 60 outpatient irrespective status diagnosed by PCR swab or RAT (rapid antigen test) within five days 14 oral (42 mg sulforaphane daily) identical microcrystalline cellulose placebo. The primary outcome this pilot feasibility conducting larger investigating (days) COVID-19-associated symptoms using supplement COVID-19-affected pregnancies. Pregnant remain at-risk group disease following currently unclear consequences offspring. Therefore, study supplement, whilst providing important safety data pregnancy.

Language: Английский

Oxidative Stress Induced by Antivirals: Implications for Adverse Outcomes During Pregnancy and in Newborns

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1518 - 1518

Published: Dec. 12, 2024

Oxidative stress plays a critical role in various physiological and pathological processes, particularly during pregnancy, where it can significantly affect maternal fetal health. In the context of viral infections, such as those caused by Human Immunodeficiency Virus (HIV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), oxidative may exacerbate complications disrupting cellular function immune responses. Antiviral drugs, while essential managing these also contribute to stress, potentially impacting both mother developing fetus. Understanding mechanisms which antivirals examination pharmacokinetic changes pregnancy that influence drug metabolism is essential. Some research indicates antiretroviral drugs induce mitochondrial dysfunction other studies suggest their use generally safe. Therefore, concerns about long-term health effects persist. This review delves into complex interplay between antioxidant defenses, antiviral therapies, focusing on strategies mitigate potential damage. By addressing gaps our understanding, we highlight importance balancing efficacy with risks stress. Moreover, advocate for further develop safer, more effective therapeutic approaches pregnancy. dynamics optimizing outcomes fetus infections

Language: Английский