Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Pre-eclampsia and fetal growth restriction (FGR) continue to cause unacceptably high levels of morbidity mortality, despite significant pharmaceutical technological advances in other disease areas. The recent pandemic has also impacted obstetric care, as COVID-19 infection increases the risk poor pregnancy outcomes. This review explores reasons why it lacks effective drug treatments for placental dysfunction that underlies many common conditions describes how nanomedicines targeted delivery approaches may provide solution current drought. ever-increasing range biocompatible nanoparticle formulations available is now making possible selectively deliver drugs uterine tissues dramatically limit transfer. Formulations are refractory uptake offer possibility retaining within maternal circulation, allowing pregnant individuals take medicines previously considered too harmful developing baby. Liposomes, ionizable lipid nanoparticles, polymeric adenoviral vectors have all been used create efficacious systems use pregnancy, although each approach offers distinct advantages limitations. It imperative be built upon there an overdue investment intellectual financial capital this field.

Language: Английский

Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review

Diagnostics, Journal Year: 2024, Volume and Issue: 14(16), P. 1775 - 1775

Published: Aug. 14, 2024

The COVID-19 pandemic has posed significant risks to pregnant women and those recently pregnant, leading heightened mortality morbidity rates. Vaccination emerged as a pivotal strategy in reducing COVID-19-related deaths illnesses worldwide. However, the initial exclusion of individuals from most clinical trials raised concerns about vaccine safety this population, contributing hesitancy. This review aims consolidate existing literature assess efficacy vaccination populations neonatal outcomes. Diverse studies were included evaluating various aspects for their newborns, encompassing mild severe symptoms across different vaccines. findings indicate overall vaccination, with minimal adverse outcomes observed, including side effects like pain fever. Although reported absence outcomes, isolated case reports have potential associations between maternal conditions such fetal supraventricular tachycardia immune-mediated diseases. Our underscores importance ongoing surveillance monitoring ensure women. Overall, during pregnancy remains safe effective strategy, emphasizing need continued research vigilance safeguard health.

Language: Английский

Shedding Light on the COVID-19 Pandemic: Placental Expression of Cell Biomarkers in Negative, Vaccinated, and Positive Pregnant Women

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5546 - 5546

Published: Sept. 19, 2024

: We investigated the expression of inflammation, placental development, and function markers, including cluster differentiation 44 (CD44), osteopontin (OPN), cyclooxygenase-2 (COX-2), to shed light on controversy regarding impact COVID-19 epidemic fetal development pregnancy outcomes.

Language: Английский