Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 651 - 651

Published: May 27, 2024

Alzheimer’s disease (AD) is a stealthy and progressive neurological disorder that leading cause of dementia in the global elderly population, imposing significant burden on both society. Currently, condition treated with medications alleviate symptoms. Nonetheless, these drugs may not consistently produce desired results can serious side effects. Hence, there vigorous pursuit alternative options to enhance quality life for patients. Ginkgo biloba (GB), an herb historical use traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, C), polyphenols, organic acids, flavonoids (quercetin, kaempferol, isorhamnetin). These are associated anti-inflammatory, antioxidant, neuroprotective properties, making them valuable cognitive health. A systematic search across three databases using specific keywords—GB AD dementia—yielded 1702 documents, selection 15 clinical trials synthesis. In eleven studies, GB extract/EGb 761® was shown improve function, neuropsychiatric symptoms, functional abilities types. four however, were no differences between GB-treated placebo groups. Significant improvements observed scores obtained from Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), Neuropsychiatric Inventory (NPI). While majority synthesized show has promising potential treatment conditions, more research needed determine optimal dosages, effective delivery methods, appropriate pharmaceutical formulations. Furthermore, thorough assessment adverse effects, exploration long-term implications, investigation into drug interactions critical aspects must be carefully evaluated future studies.

Language: Английский

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Dehydration-responsive element-binding transcription factor, GuDREB35, positively regulates drought tolerance in licorice (Glycyrrhiza uralensis)

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141829 - 141829

Published: March 6, 2025

Language: Английский

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Analysis of Ginkgo biloba Root Exudates and Inhibition of Soil Fungi by Flavonoids and Terpene Lactones

Plants, Journal Year: 2024, Volume and Issue: 13(15), P. 2122 - 2122

Published: Aug. 1, 2024

is abundant in secondary metabolites, including flavonoids and terpenoids. While the majority of research has focused on role these compounds disease resistance, their specific contribution to pathogen defense been rarely explored. In this study, we collected root exudates from hydroponically cultivated ginkgo seedlings conducted a metabolomic analysis. We identified several primary metabolites mainly comprising amino acids nucleotides, while consisted various compounds, bioactive such as Focusing with relatively higher abundance exudates, selected mixture terpenoids for vitro inhibition experiments against two soil-borne fungal pathogens,

Language: Английский

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Editorial: Tree Biology: From Genomics to Genetic Improvement

Plant Science, Journal Year: 2024, Volume and Issue: 350, P. 112315 - 112315

Published: Nov. 10, 2024

Language: Английский

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