Published: Jan. 1, 2023

The problem of microplastics (MPs) contamination in food has gradually come to the fore. MPs can be transmitted through chain and accumulate within various organisms, ultimately posing a threat human health. For first time, we compared differences toxicity polyethylene terephthalate (PET), polyvinyl chloride (PVC), polystyrene (PS) nanoplastics (NPs) different polymer types HepG2 cells their potential toxic mechanisms. Common polymers PET, PVC, PS NPs, which had similar particle size, surface charge, shape, were prepared using nanoprecipitation emulsion polymerization successfully. This enabled us investigate impact on cytotoxicity. findings demonstrated that high concentrations PET PVC NPs trigger cell apoptosis oxidative stress, but did not have same harmful impact. Furthermore, our analysis transcriptomics data revealed significantly reduced expression genes related bile acid metabolism PPAR signaling pathway. effect may lead perturbation cellular lipid metabolism. resulted higher degree down-regulation these NPs. It is worth noting inhibit cycle DNA repair-related p53 pathway, aggravating damage arresting progression by inhibiting repair. constitute principal factor accounting for variations across types. These comparative studies discoveries regarding molecular mechanisms provide theoretical basis mitigating health risks stemming from

Language: Английский