
Current Plant Biology, Journal Year: 2024, Volume and Issue: 40, P. 100413 - 100413
Published: Nov. 6, 2024
Language: Английский
Current Plant Biology, Journal Year: 2024, Volume and Issue: 40, P. 100413 - 100413
Published: Nov. 6, 2024
Language: Английский
Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 214, P. 108950 - 108950
Published: July 18, 2024
Citations
5International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 821 - 821
Published: Jan. 19, 2025
As a crucial post-translational modification (PTM), protein ubiquitination mediates the breakdown of particular proteins, which plays pivotal role in large number biological processes including plant growth, development, and stress response. The ubiquitin-proteasome system (UPS) consists ubiquitin (Ub), ubiquitinase, deubiquitinating enzyme (DUB), 26S proteasome more than 80% degradation for turnover plants. For ubiquitinases, ubiquitin-activating (E1), ubiquitin-conjugating (E2), ligase (E3), FBK (F-box Kelch repeat protein) is an essential component multi-subunit E3 SCF (Skp1-Cullin 1-F-box) involved specific recognition target proteins UPS. Many genes have been identified different species, regulates growth development through affecting endogenous phytohormones as well tolerance to various biotic abiotic stresses associated with changes secondary metabolites such phenylpropanoid, phenolic acid, flavonoid, lignin, wax, etc. review summarizes significance protein, UPS degradation, possible function metabolism, response, provides systematic comprehensive understanding mechanism potential FBKs species.
Language: Английский
Citations
0Published: Jan. 1, 2025
Language: Английский
Citations
0Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16
Published: March 26, 2025
Plants synthesize an extensive array of secondary metabolites in response to diverse biotic and abiotic stresses. These function not only as defensive compounds but also constitute significant sources nutrition pharmaceuticals. However, the mechanisms governing synthesis these have long been a central focus research continue pose challenges. Transcription factors (TFs), serving key regulators metabolite plants, exhibit action that are still fully understood. This review summarizes latest advancements on how plant transcription mediate regulation biosynthesis through various signaling pathways, including light signaling, hormone MAPK ubiquitin-proteasome pathway, epigenetic regulation, microbial interactions, climate change. A deeper understanding regulating is expected provide new insights into metabolites.
Language: Английский
Citations
0ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Plant-derived extracellular vesicles are of great significance in practical applications due to their availability, low immunogenicity, and effective carrier performance. Isodon rubescens-derived (IRDVs) not only have the capability for drug-carrying targeted therapy but also exhibit certain anti-inflammatory antitumor effects as part traditional Chinese medicine. The harvest time is closely related quality its medicinal ingredients; however, whether there differences IRDVs harvested at different times has yet be explored. Herein, we analyzed morphology chemical composition collected points identified six-month-harvested most suitable delivery vector. To further enhance therapeutic potential, modified with deoxycholic acid facilitate oral chemotherapy drug doxorubicin (DOX). This novel nanotherapy, termed DOX-IRDVs@DA, was developed an treatment colitis-associated cancer (CAC). results demonstrated that DOX-IRDVs@DA effectively delivered DOX colon tumor 26 (CT26) cells, induced cell apoptosis by modulating apoptosis-related proteins, inhibited proliferation CT26 cells. In vivo studies a mouse model CAC revealed achieved superior effects, reducing number colonic nodules, restoring structural integrity colon, causing minimal systemic toxicity.
Language: Английский
Citations
0Life, Journal Year: 2025, Volume and Issue: 15(5), P. 697 - 697
Published: April 25, 2025
Long non-coding RNAs (lncRNAs) have been defined as transcripts exceeding 200 nucleotides, which play essential roles during transcriptional and post-transcriptional regulation in multiple biological processes. Understanding R. delavayi lncRNAs is of great significance it profoundly influenced by heat stress. In this research, a total 1145 differentially expressed (DE-lncRNAs) 9447 genes (DEGs) (log2|FC| > 1, p < 0.05) were characterized between heat-stress-treated groups control groups. Further analysis showed that 229 DE-lncRNAs (144 upregulated 85 downregulated) commonly distributed two comparisons (CK_vs._H3 CK_vs._H6). We further investigated the cis- trans-acting DE-lncRNAs, found 142 corresponded to 1565 cis-acting DEGs, 143 3417 DEGs. KEGG enrichment these target revealed DEGs DE-lncRNA primarily enriched five twelve pathways, respectively. Co-expression network common pathways 57 co-expression relationships 28 43 554 26 90 Six six their used candidate verify RNA-seq data using qRT-PCR. three (TrxG, PEPC, CCR) out selected for subsequent research. This study examined relationship screened can potentially provide an important theoretical basis experimental genetic improvement tolerance delavayi.
Language: Английский
Citations
0Insect Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 27, 2025
Abstract Nitrogen is an essential element for the synthesis of proteins, nucleic acids, and various other critical biological molecules in insects. The maintenance nitrogen homeostasis insects achieved through a balance dietary intake, metabolic conversion, excretion. Insects primarily acquire from their diet, which subsequently metabolized into amino vital biomolecules following digestion absorption. Excess excreted forms such as uric acid, allantoin, allantoic urea, ammonia. Disruptions regulation can result ammonia toxicity abnormal production or excretion nitrogenous metabolites, including ultimately impairing insect development survival. This review examines mechanisms underlying insects, with focus on intricate regulatory roles carbohydrate metabolism, acid urea polyamine transport pathways, symbiotic interactions. By elucidating these processes, this aims to enhance our understanding nutritional metabolism developmental biology, while offering novel perspectives more effective pest management strategies.
Language: Английский
Citations
0Published: Jan. 1, 2025
Language: Английский
Citations
0Plant Cell & Environment, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 16, 2024
ABSTRACT Biosynthesis of specific secondary metabolites in plants involves fine regulation gene expression. Camellia chekiangoleosa has important economic value: the seeds contain high‐quality unsaturated fatty acids and pericarp is rich tea saponins. As an posttranscriptional regulator, role microRNAs (miRNAs) controlling metabolism C. not fully studied. Here, we investigated miRNAs their targets metabolic regulatory network by comprehensively analyzing small RNAs, transcriptomes, degradomes from different tissues. We identified 168 known 74 novel genome revealed 15 tandem clusters containing 35 miRNAs. By establishing a miRNAs, target genes, transcription factors, unravelled multiplicity miRNA tissue‐specific expression, which may be tightly linked to synthesis metabolites. Furthermore, characterized long‐noncoding (cch‐miR3633) that targeted UDP‐transferase ( CchUGT94E5 ). showed that, ectopic expression caused outgrowth shoot branching changes cytokinin contents Arabidopsis , indicating potential regulating metabolism. This work provides valuable information for study
Language: Английский
Citations
2International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135266 - 135266
Published: Sept. 6, 2024
Language: Английский
Citations
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