Celastrol Improves Preference for a Fatty Acid, and Taste Bud and Systemic Inflammation in Diet-Induced Obese Mice DOI Open Access

M. Benmouna,

Chahid Benammar,

Amira Sayed Khan

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1308 - 1308

Published: April 9, 2025

Background: Obesity is associated with the altered gustatory perception of dietary fatty acids. Celastrol, a triterpene, has been demonstrated to exert anti-obesity effects in rodents. We assessed role Celastrol modulation oro-sensory lipids control and high-fat diet (HFD)-induced obese mice. Methods: Male mice C57B/6J strain were fed HFD for 11 weeks then administered or not further 4 weeks. The body weight was recorded weekly. Before sacrifice, animals subjected detection long-chain acid two-bottle choice paradigm. After fungiform taste buds isolated analyzed mRNA expression, encoding fat sensors (CD36 GPR120) pro-inflammatory cytokines (IL-1β, IL-6 TNF-α). Circulating concentrations TNF-α also determined, liver used analyze expression lipogenic genes. Results: administration decreased re-established loss acid, this phenomenon was, part, due upregulation mRNA, receptors tongue bud cells. Furthermore, inflammation both blood circulation. Conclusions: Our findings suggest that decreases gain, ameliorates lipids, downregulates

Language: Английский

Celastrol Improves Preference for a Fatty Acid, and Taste Bud and Systemic Inflammation in Diet-Induced Obese Mice DOI Open Access

M. Benmouna,

Chahid Benammar,

Amira Sayed Khan

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1308 - 1308

Published: April 9, 2025

Background: Obesity is associated with the altered gustatory perception of dietary fatty acids. Celastrol, a triterpene, has been demonstrated to exert anti-obesity effects in rodents. We assessed role Celastrol modulation oro-sensory lipids control and high-fat diet (HFD)-induced obese mice. Methods: Male mice C57B/6J strain were fed HFD for 11 weeks then administered or not further 4 weeks. The body weight was recorded weekly. Before sacrifice, animals subjected detection long-chain acid two-bottle choice paradigm. After fungiform taste buds isolated analyzed mRNA expression, encoding fat sensors (CD36 GPR120) pro-inflammatory cytokines (IL-1β, IL-6 TNF-α). Circulating concentrations TNF-α also determined, liver used analyze expression lipogenic genes. Results: administration decreased re-established loss acid, this phenomenon was, part, due upregulation mRNA, receptors tongue bud cells. Furthermore, inflammation both blood circulation. Conclusions: Our findings suggest that decreases gain, ameliorates lipids, downregulates

Language: Английский

Citations

0