Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 9, 2024
The
rumen
microbiota—a
symbiont
to
its
host
and
consists
of
critical
functional
substances—plays
a
vital
role
in
the
animal
body
represents
new
perspective
study
adaptive
evolution
animals.
This
used
Slide
Viewer
slicing
analysis
system,
gas
chromatography,
RT-qPCR
other
technologies,
as
well
16S
metabolomics
determination
methods,
measure
analyze
microstructure
epithelium,
fermentation
parameters,
transport
genes,
microbiota
metabolites
Tibetan
sheep
Hu
sheep.
results
indicate
that
nipple
height
cuticle
thickness
are
significantly
greater
than
those
(
p
<
0.01)
digestion
absorption
forage
greater.
levels
carbohydrate
metabolism,
lipid
protein
turnover
were
increased
sheep,
which
enabled
them
ferment
efficiently,
utilize
forage,
absorb
metabolic
volatile
fatty
acids
(VFAs).
related
immune
function
energy
regulate
growth
development
gastrointestinal
homeostasis.
Thus,
compared
with
have
more
papilla
corneum,
synergistic
effect
is
characteristic
strategy
for
adapting
high-altitude
environments.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Globally,
breast
cancer
represents
the
most
common
and
primary
cause
of
death
by
in
women.
Lipids
are
crucial
human
physiology,
serving
as
vital
energy
reserves,
structural
elements
biological
membranes,
essential
signaling
molecules.
The
metabolic
reprogramming
lipid
pathways
has
emerged
a
critical
factor
progression,
drug
resistance,
patient
prognosis.
In
this
study,
we
delve
into
clinical
implications
pathway-targeted
therapy
cancer.
We
highlight
key
enzymes
potential
therapeutic
targets
involved
metabolism
reprogramming,
their
associations
with
progression
treatment
outcomes.
Furthermore,
detail
trials
exploring
anticancer
chemopreventive
activity
therapies
targeting
these
However,
efficacy
remains
controversial,
highlighting
urgent
need
for
predictive
biomarkers
to
identify
subpopulations
likely
benefit
from
such
treatment.
propose
Selective
Lipid
Metabolism
Therapy
Benefit
Hypothesis,
emphasizing
importance
personalized
medicine
optimizing
patients.
Chemistry and Physics of Lipids,
Journal Year:
2025,
Volume and Issue:
267, P. 105471 - 105471
Published: Jan. 9, 2025
Dental
fluorosis,
as
a
common
chronic
fluoride
toxicity
oral
disease,
is
mainly
caused
by
long-term
excessive
intake
of
fluoride,
which
seriously
affects
the
aesthetics
and
function
patients'
teeth.
In
recent
years,
with
rapid
development
metabolomics
technology,
lipidomics,
an
important
means
to
study
changes
in
lipid
metabolism
organisms,
has
shown
great
potential
revealing
mechanisms
disease
development.
As
major
component
cell
membranes
signaling
molecule,
metabolic
disorders
lipids
are
closely
related
variety
diseases,
but
specific
mechanism
action
dental
fluorosis
still
unclear.
Therefore,
present
aimed
systematically
analyze
differences
profiles
between
patients
healthy
populations
using
broad-based
targeted
lipidomics
technology
provide
new
perspectives
on
pathogenesis
fluorosis.
To
this
end,
researchers
compared
salivary
lipidome
participants
micro
patients.
Their
saliva
samples
were
collected,
advanced
combined
high-performance
liquid
chromatography-mass
spectrometry
(LC-MS)
system,
was
used
comprehensively
detect
quantify
samples.
The
data
processed
analyzed
bioinformatics
identify
unique
patterns
verify
significance
these
statistical
methods.
Several
glycerophospholipids,
fatty
acyls,
sphingolipids
exhibited
marked
alterations
Among
these,
glycocholic
acid,
LPA
(18:4),
taurolithocholic
acid-3-sulfate,
lithocholic
taurochenodeoxycholic
acid-3-sulfate
observed
controls.
acid
significantly
decreased,
while
PA
(12:0_12:0)
levels
elevated.
These
findings
suggest
that
disturbances
play
crucial
role
developing
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 3, 2025
In
recent
years,
hyperoside
(quercetin
3-O-β-D-galactopyranoside)
has
garnered
significant
attention
due
to
its
diverse
biological
effects,
which
include
vasoprotective,
antioxidant,
anti-inflammatory,
and
anti-tumor
properties.
Notably,
shown
remarkable
potential
in
cancer
therapy
by
targeting
multiple
mechanisms;
it
induces
apoptosis,
inhibits
proliferation,
blocks
angiogenesis,
reduces
the
metastatic
of
cells.
Furthermore,
enhances
sensitivity
cells
chemotherapy
modulating
key
signaling
pathways.
Beyond
neoplastic
diseases,
also
presents
promising
therapeutic
applications
managing
non-cancerous
conditions
such
as
diabetes,
Alzheimer’s
disease,
pulmonary
fibrosis.
This
review
comprehensively
examines
molecular
mechanisms
underlying
hyperoside’s
anti-cancer
effects
highlights
role
treatment
cancers,
including
lung
colorectal
cancers.
Additionally,
explores
latest
research
on
addressing
non-neoplastic
conditions,
fibrosis,
Parkinson’s
disease.
By
summarizing
current
findings,
this
underscores
unique
value
a
multifunctional
both
contexts.
American Journal of Preventive Cardiology,
Journal Year:
2025,
Volume and Issue:
22, P. 100958 - 100958
Published: March 9, 2025
Circadian
disruption
and
sleep
disorders
have
been
shown
to
increase
the
risk
for
many
cardiovascular
diseases.
Their
association
specifically
with
valvular
heart
disease,
however,
is
inconclusive.
In
this
study
we
test
between
future
incidence
of
aortic
stenosis
using
two
large
electronic
health
record
(EHR)
databases
datasets
(the
TriNetX
network
All
Us
study).
We
also
explore
biochemical
data
potential
mechanistic
insights
into
that
association.
fitted
Cox
proportional
hazards
models
quantify
AS
in
patients
disorders.
explored
clinical
laboratory
signals
might
explain
association,
running
mediation
analyses.
our
fully
adjusted
models,
find
having
any
disorder
increases
(HR:
1.15
95
%
CI:
1.13-1.18).
Changes
lipid
profile
mediate
a
proportion
Sleep
are
associated
an
increased
incidence.
That
independent
classical
factors
even
though
dyslipidemia
plays
role
mediating
risk.
Medical alphabet,
Journal Year:
2025,
Volume and Issue:
7, P. 28 - 35
Published: March 23, 2025
Polycystic
ovary
syndrome
(PCOS)
is
the
most
common
endocrine
disorder
in
women
of
reproductive
age
for
which
a
lifestyle
approach
an
integral
part
treatment.
Despite
modern
therapies
this
syndrome,
significant
number
with
condition
do
not
achieve
treatment
goals,
suggesting
that
there
are
other
features
taken
into
account
assessment
and
therefore
choice
therapeutic
approach.
Chronotype
known
to
play
role
determining
dietary
preferences
risk
developing
endocrine-metabolic
diseases,
including
those
PCOS.
Aim
:
study
differences
circadian
rhythms
PCOS
evaluate
their
metabolic
aspects
disease.
Materials
methods
109
aged
18–36
years
(mean
26.3±4.3
years)
confirmed
diagnosis
were
included
divided
3
groups
according
chronotype:
Group
1
(evening
chronotype)
–
19
(17.4
%)
subjects,
2
(intermediate
38
(34.9%)
subjects
(morning
52
(47.7%)
subjects.
All
patients
underwent
standard
clinical,
laboratory
instrumental
examinations
determine
status
PCOS,
as
well
medical
history
physical
examination
anthropometric
parameters.
Results
evening
chronotype
exercised
less
regularly
significantly
physically
active,
had
higher
rates
smoking
arterial
hypertension
than
types
rhythm.
The
was
associated
body
mass
index
(BMI;
p=0.001),
waist
hip
circumference
(WC
HC;
p=0.004
p=0.003,
respectively),
WC/HC
ratio
(p=0.017),
neck
(NC;
p=0.013),
Deurenberg
fat
percentage
(p=0.001),
lower
prolactin
25(OH)D
levels
(p=0.046
p=0.037,
respectively)
compared
mid-phase
phenotype.
And
morning
phenotype,
phenotypes
BMI
(p<0.001),
WC
HC
OB
(p=0.009),
NC
(p<0.001)
very
low
density
lipoproteins
(p=0.042),
ApoA1
insulin
(p=0.020),
HOMA-IR
(p=0.035)
(p=0.004).
Low-density
lipoproteinemia
more
variant
group
isolated
lipid
abnormalities
intermediate
(p=0.028).
Conclusions
have
worse
indices,
severe
degree
IR
general
likely
lead
healthy
lifestyle,
suffer
often
from
chronotypes.
Further
rhythm
has
potential
may
help
develop
effective
strategies
Advances in Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100416 - 100416
Published: March 1, 2025
The
circadian
rhythm
arises
endogenously
from
genetically
encoded
molecular
clocks,
wherein
the
components
collaborate
to
induce
cyclic
fluctuations,
occurring
approximately
every
24
hours.
rhythms
synchronize
biological
processes
with
regular
and
predictable
environmental
patterns
guarantee
host
metabolism
energy
homeostasis
function
well-being.
Disruptions
are
widely
associated
metabolic
disorders.
Notably,
microbial
influenced
by
both
host's
intrinsic
clock
external
rhythmic
factors
(i.e.,
light-dark
cycle,
diet
composition),
which
affect
structure
of
communities
functions.
Moreover,
microbiota
metabolites
also
reciprocally
influence
rhythms,
potentially
impacting
function.
This
review
explores
bidirectional
interactions
between
clock,
influencing
host-microbial
effects
on
lipid
homeostasis.
STATEMENT
OF
SIGNIFICANCE:
highlighting
gut
microbiota,
metabolites,
rhythms.
Additionally,
it
emphasizes
impact
disruptions
in
development
diseases.
Abstract
Insulin-like
growth
factor
2
messenger
RNA
(mRNA)-binding
protein
(IGF2BP2)
is
a
widely
studied
N
6
-methyladenosine
(m
A)
modification
reader,
primarily
functioning
to
recognize
and
bind
m
A
sites
on
the
mRNA
of
downstream
target
genes,
thereby
enhancing
their
stability.
Previous
studies
have
suggested
that
IGF2BP2-m
plays
an
essential
role
in
cellular
functions
progression
various
diseases.
In
this
review,
we
focus
summarizing
molecular
mechanisms
by
which
IGF2BP2
enhances
stability
genes
through
modification,
regulating
cell
ferroptosis,
epithelial–mesenchymal
transition
(EMT),
stemness,
angiogenesis,
inflammatory
responses,
lipid
metabolism,
ultimately
affecting
disease
progression.
Additionally,
update
related
research
progress
IGF2BP2.
This
article
aims
elucidate
effects
EMT,
providing
new
perspective
for
comprehensive
understanding
relationship
between
such
as
ferroptosis
well
potential
targeted
therapy
tumors
other
