The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications DOI Creative Commons

Jennifer Schild,

Aneta Kalvodová, Jarmila Zbytovská

et al.

International Journal of Cosmetic Science, Journal Year: 2024, Volume and Issue: 46(4), P. 526 - 543

Published: Aug. 1, 2024

Abstract Ceramides are a family of lipids constituted by sphingoid base and fatty acid. In the skin, they mainly present in stratum corneum where, with cholesterol free acids, constitute inter‐corneocyte lipids. With other lipid groups, play key role formation dense lamellar structures between adjacent corneocytes, collectively ensuring vital efficient barrier to water evaporation protection from foreign agents´ penetration. Changes ceramide level relative composition, potential impairment arrangement, have been evidenced different skin conditions diseases. Therefore, use suitably formulated ceramides has proposed for topical treatment help re‐structure damaged arrangement repair impaired function. Nonetheless, formulation products necessitates specific processes such as heating high temperature before their introduction final formula. this review on structure, skincare, we point out necessity rigorous process when formulating into product. We demonstrate counterproductive effects undissolved capacity formulas, assessed vitro models disrupted barrier.

Language: Английский

κ-Carrageenan tetrasaccharide ameliorates particulate matter-induced defects in skin hydration of human keratinocytes cells and skin barrier disorders DOI

Chun‐Hua Zhu,

Tao Hong, Hebin Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140395 - 140395

Published: Jan. 1, 2025

Language: Английский

Citations

0
Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models DOI Creative Commons
Dewald Steyn, Anja Haasbroek‐Pheiffer, Wihan Pheiffer

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 195 - 195

Published: Jan. 31, 2025

Drugs administered by means of extravascular routes drug administration must be absorbed into the systemic circulation, which involves movement molecules across biological barriers such as epithelial cells that cover mucosal surfaces or stratum corneum covers skin. Some drugs exhibit poor permeation membranes may experience excessive degradation during first-pass metabolism, tends to limit their bioavailability. Various strategies have been used improve Absorption enhancement include co-administration chemical enhancers, enzymes, and/or efflux transporter inhibitors, changes, and specialized dosage form designs. Models with physiological relevance are needed evaluate efficacy absorption techniques. in vitro cell culture models ex vivo tissue explored quantify effectiveness strategies. This review deliberates on use for evaluation selected including nasal, oromucosal, pulmonary, oral, rectal, transdermal administration.

Language: Английский

Citations

0
Niacinamide and its impact on stratum corneum hydration and structure DOI Creative Commons
Thomas Sjöberg,

Andebrhan Fsahaye,

Emelie J. Nilsson

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 10, 2025

Abstract Niacinamide (NIA) is widely used in skincare for its favorable safety profile, anti-aging effects, and proven clinical efficacy treating various skin conditions. However, direct impact on the hydration molecular organization of stratum corneum (SC), primary barrier, remains unclear. This study examines how NIA influences SC’s lipid matrix organization, soft keratin structure, water sorption behavior across varying relative humidity (RH) levels. Using small- wide-angle X-ray diffraction dynamic vapor measurements, we compared NIA-treated SC samples to untreated controls under different RHs. The main findings show that while non-hygroscopic, it enhances uptake at high (95% RH). At low (60% RH), swells monomer spacing, although content low, suggesting a plasticizing effect could increase flexibility dry also modifies intensities from differently 60% 95% RH, implying interacts with distribution within protein domains. These effects appear independent investigated dose regime, indicating specific concentration threshold. Overall, shows distinct interaction keratin, swelling spacing between monomers conditions, without acting as traditional keratolytic agent.

Language: Английский

Citations

0
Skin-penetrating peptides (SKPs): Enhancing skin permeation for transdermal delivery of pharmaceuticals and cosmetic compounds DOI
Aliyu Muhammad, Ahmad Filza Ismail, Pei Pei Chong

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125339 - 125339

Published: Feb. 1, 2025

Language: Английский

Citations

0
A Scenario-Adaptive Microfluidic Chip for Constructing In Vitro Models of Biological Barriers DOI

Yaran Chang,

Chen Tian, Shanshan Geng

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Microfluidic-based in vitro physiological barrier models are capable of simulating crucial environmental factors during formation, including fluid shear and geometric-level cellular cocultures, thus offering enhanced fidelity relative to conventional platforms. However, the sealed structure microfluidic chips faces challenges characterizing monitoring performance, especially measuring transendothelial/epithelial electrical resistance (TEER). Here, we developed a chip that can be easily adapted commercial TEER detectors. During construction phase, continuous perfusion culture was utilized maintain constant stress; for characterization, meters were employed measure directly. Using this chip, successfully constructed an blood–brain model with approximately 220 Ω·cm2, indicating high relevance. This scenario-adaptive demonstrates extensive potential developing organ-on-a-chip across various systems, significant implications characteristic situ cell sampling within chip.

Language: Английский

Citations

0
The Impacts of Seasonal Factors on Psoriasis DOI

Jundan Yang,

Guohao Li,

Lixin Yue

et al.

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(3)

Published: March 1, 2025

ABSTRACT Psoriasis is a chronic inflammatory skin condition driven by immune system dysfunction, genetic predisposition and environmental factors. Patients with psoriasis experience well‐known clinical phenomenon of ‘winter severity summer relief’, in which seasonal factors play critical roles the onset progression psoriasis. These include temperature, humidity, infection, light exposure psychological stress. Seasonal changes temperature humidity can compromise barrier function exacerbate responses, thereby worsening symptoms. Notably, during winter, decreased leads to reduced vitamin D (VD) levels, reaching their lowest levels from late winter early spring. This decline VD associated increased disease activity, greater more frequent flare‐ups patients During influenza Streptococcus pneumoniae infections are prevalent, further Moreover, conditions trigger or intensify feelings depression, may adversely affect through brain–skin axis. In this comprehensive review, we thoroughly examined influence on incidence, recurrence By clarifying these complex relationships, aimed support future development personalised effective treatment management strategies for

Language: Английский

Citations

0
Unveiling the behavior of cubic and reverse hexagonal liquid crystalline nanoparticles in cellular and skin delivery of glucocorticoid and small interfering RNA DOI
Ana Vitória Pupo Silvestrini, Uziel Paulo da Silva, Márcia Carvalho de Abreu Fantini

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127442 - 127442

Published: March 1, 2025

Language: Английский

Citations

0
Costunolide nanosuspension loaded in dissolvable microneedle arrays for atopic dermatitis treatment DOI

Xulong Xue,

Pengcheng Zhang, Yang Cao

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125566 - 125566

Published: April 1, 2025

Language: Английский

Citations

0
Nanotechnology-driven nanoemulsion gel for enhanced transdermal delivery of Sophora alopecuroides L. empyreumatic oil: formulation optimization, and anti-biofilm efficacy DOI Creative Commons
Xin R. Cheng, Xiangyu Zhou, Wenping Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 25, 2025

Sophora alopecuroides L. empyreumatic oil (SoA oil) exhibits therapeutic potential for psoriasis and eczema but suffers from poor skin permeability formulation challenges. To overcome these limitations, a nanoemulsion (NE) gel was developed. The NE optimized using pseudo-ternary phase diagrams characterized droplet size, polydispersity index (PDI), zeta potential, rheological properties. Skin retention were assessed in vitro Franz diffusion cells, with oxymatrine quantified by HPLC. In vivo irritation tested on rabbit dorsal skin, anti-biofilm activity evaluated against Staphylococcus aureus ( S . ) methicillin-resistant S. (MRSA). A final concentration of 5% SoA the used subsequent studies. (the NE) had mean size 53.27 nm, PDI 0.236, −38.13 mV. Adding 2% carbomer 940 (CP940) to enhanced viscoelasticity. showed superior higher cutaneous oxymatrine. caused moderate rabbits, while other two formulations did not. demonstrated biofilm inhibition at 0.09766 mg/mL, an 8.9% rate surpassing (2.0%) gel, 4.0%). At 12.50 achieved slightly rates (81.7% 82.1%, respectively) than (78.3%). Notably, significantly greater effects MRSA within range 3.12 mg/mL P < 0.001). mature clearance , 4.9% 2.3% 0.8%, respectively. increased 38.1%, outperforming (29.1%) (36.4%). Against MRSA, displayed improved (42.7% 43.9%, compared (31.9%) 0.0001). These findings highlight nanotechnology-driven delivery systems improve clinical application herbal extracts treating biofilm-associated dermatological infections.

Language: Английский

Citations

0
Unraveling UVB effects: Catalase activity and molecular alterations in the stratum corneum DOI Creative Commons

Nikol Labecka,

Michal Szczepanczyk,

Enamul Haque Mojumdar

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 666, P. 176 - 188

Published: March 30, 2024

Ultraviolet B (UVB) radiation can compromise the functionality of skin barrier through various mechanisms. We hypothesize that UVB induce photochemical alterations in components outermost layer skin, known as stratum corneum (SC), and modulate its antioxidative defense Catalase is a well-known enzyme found SC where it acts to scavenge reactive oxygen species. However, detailed characterization acute exposure on activity native catalase lacking. Moreover, effects irradiation molecular dynamics organization keratin lipid remain unclear. Thus, aim this work characterize consequences structural properties catalase, well global matrix surrounding enzyme.

Language: Английский

Citations

3