Metal-organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy DOI
Tao Jiang,

Zixiang Tang,

Shaolei Tian

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Sonodynamic therapy (SDT) has demonstrated significant clinical potential in malignant tumor treatment due to its deep tissue penetration and spatiotemporal controllability. Its core mechanism relies on ultrasound-activated sonosensitizers generate reactive oxygen species (ROS), thereby inducing cell apoptosis. However, conventional face limitations ROS yield tumor-targeting efficiency. In this study, we innovatively designed a multifunctional metal-organic nanosheet (TiZrRu-MON) by hydrothermal coordination of [Ru(bpy)3]2+ photosensitizing units with TiZr-O clusters, while incorporating Fe3+ construct cascade catalytic system. Experimental results that: (1) lattice doping significantly enhanced charge carrier mobility ultrasound-triggered 1O2 quantum via the formation transfer channels; (2) The acidic microenvironment activated Fe3+-mediated Fenton reactions, establishing positive feedback loop SDT synergistically amplify generation; (3) Hyaluronic acid functionalization improved internalization HepG2 cells through CD44 receptor-mediated endocytosis. Remarkably, ultrasound irradiation induced substantial oxidative stress immunogenic death, promoting release damage-associated molecular patterns (DAMPs), which elevated maturation rate tumor-infiltrating dendritic (DCs) increased proportion CD8+ T cells. mouse subcutaneous model, system achieved effective suppression manageable systemic toxicity. This work proposes metal-ligand strategy advance development high-performance immunomodulatory antitumor technologies.

Language: Английский

Hybrid amorphous titanium dioxide/amphiphilic graft copolymer nano-sonosensitizers DOI Creative Commons
L. Weiss, Ivan Zlotver,

Diana Solovyov

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: 45, P. 112260 - 112260

Published: March 18, 2025

Language: Английский

Citations

1
Acid‐Responsive Bacteria‐Targeted Zinc‐Porphyrin Based Sonosensitizer with Enhancing Antibacterial Efficacy and Biofilm Eradication for Infected Wounds Healing DOI Open Access

Xingjun Zhao,

Jiaxin Li, Peng Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.

Language: Английский

Citations

0
Editing Benzotrithiophene-Based Covalent Organic Frameworks for Developing New Sonosensitizers DOI
Chunyuan Hou,

Nan Han,

Bin Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent therapeutic effect. Particularly, because enhanced D-A effect that promotes charge separation transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight great potential elaborate editing configurations as suitable candidates advanced sonosensitizers.

Language: Английский

Citations

0
Hybrid amorphous titanium dioxide/polymeric nano-sonosensitizers towards the actively targeted sonodynamic therapy of brain cancer DOI Creative Commons
Ivan Zlotver,

Noa Shechtman,

Alejandro Sosnik

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137702 - 137702

Published: April 25, 2025

Language: Английский

Citations

0
Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO3 Piezoelectric Nanomaterials in Tumor Treatment DOI Creative Commons

Yajuan Gong,

Qi Jin, Shuo Huang

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.

Language: Английский

Citations

0
Progress of metal-organic frameworks in improving the effect of sonodynamic therapy DOI Creative Commons
Qiang Cai, Jine Wang,

Ruhui Yan

et al.

Biomedical Technology, Journal Year: 2025, Volume and Issue: 9, P. 100070 - 100070

Published: Feb. 14, 2025

Language: Английский

Citations

0
Ultrasound‐Triggered Cascade Delivery via Poly‐Oxaliplatin Nanoparticles for Immunotherapy DOI Open Access

Meifang Shen,

Yushu Wang, Lingpu Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Oxaliplatin (OXA), a third‐generation platinum‐based chemotherapeutic agent, is widely utilized in cancer treatment due to its potent cytotoxic effects and ability induce immunogenic cell death (ICD). However, the clinical application of OXA significantly hindered by inefficient drug delivery. To address these challenges, cascade delivery system that integrates ultrasound (US) activation with Poly‐Oxaliplatin nanoparticles (OXA‐Ce6 NP) developed enhance therapeutic efficacy overcome resistance mechanisms OXA. This sono‐responsive platform consists an amphiphilic polymer incorporating OXA(IV) prodrug (Poly‐OXA(IV)) sonosensitizer chlorin e6 (Ce6), enabling US‐triggered cascade. Upon US exposure, this facilitates 1) enhanced cellular uptake via increased membrane permeability, 2) situ through electron transfer, 3) augmented formation OXA‐DNA adducts, thereby intensifying DNA damage effects. Moreover, US‐induced reactive oxygen species (ROS) further potentiate ICD, remodeling tumor immune microenvironment promoting systemic antitumor immunity. By leveraging as external stimulus, enhances outcome while mitigating toxicity. strategy provides versatile approach optimizing chemotherapy integrating immunotherapy, offering promising avenue for improving treatments.

Language: Английский

Citations

0
Metal-organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy DOI
Tao Jiang,

Zixiang Tang,

Shaolei Tian

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Sonodynamic therapy (SDT) has demonstrated significant clinical potential in malignant tumor treatment due to its deep tissue penetration and spatiotemporal controllability. Its core mechanism relies on ultrasound-activated sonosensitizers generate reactive oxygen species (ROS), thereby inducing cell apoptosis. However, conventional face limitations ROS yield tumor-targeting efficiency. In this study, we innovatively designed a multifunctional metal-organic nanosheet (TiZrRu-MON) by hydrothermal coordination of [Ru(bpy)3]2+ photosensitizing units with TiZr-O clusters, while incorporating Fe3+ construct cascade catalytic system. Experimental results that: (1) lattice doping significantly enhanced charge carrier mobility ultrasound-triggered 1O2 quantum via the formation transfer channels; (2) The acidic microenvironment activated Fe3+-mediated Fenton reactions, establishing positive feedback loop SDT synergistically amplify generation; (3) Hyaluronic acid functionalization improved internalization HepG2 cells through CD44 receptor-mediated endocytosis. Remarkably, ultrasound irradiation induced substantial oxidative stress immunogenic death, promoting release damage-associated molecular patterns (DAMPs), which elevated maturation rate tumor-infiltrating dendritic (DCs) increased proportion CD8+ T cells. mouse subcutaneous model, system achieved effective suppression manageable systemic toxicity. This work proposes metal-ligand strategy advance development high-performance immunomodulatory antitumor technologies.

Language: Английский

Citations

0