Current Opinion in Obstetrics & Gynecology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Purpose
of
review
This
examines
Turkey's
cervical
cancer
screening
programme,
highlighting
its
evolution
from
a
cytology-based
approach
to
more
effective
HPV-based
strategy.
The
is
timely
given
the
global
push
reduce
incidence
through
improved
practices,
and
it
positions
programme
as
potential
model
for
other
countries
facing
similar
public
health
challenges.
Recent
findings
advances
in
Turkey
include
nationwide
introduction
HPV
DNA
testing,
centralized
laboratory
systems
innovative
management
software.
has
significantly
coverage
early
detection
rates,
particularly
underserved
communities.
However,
challenges
remain
areas
such
training
healthcare
workers,
raising
awareness
vaccination,
integrating
self-sampling
methods
into
process.
Summary
Turkish
experience
demonstrates
that
well
organized
can
overcome
significant
cultural
logistical
barriers
lead
outcomes.
Future
efforts
should
focus
on
refining
triage
strategies,
exploring
new
molecular
tests,
expanding
use
further
improve
effectiveness
prevention
worldwide.
Reports — Medical Cases Images and Videos,
Journal Year:
2024,
Volume and Issue:
7(3), P. 71 - 71
Published: Aug. 18, 2024
(1)
Background:
Cervical
cancer,
caused
mainly
by
high-risk
Human
Papillomavirus
(hrHPV),
is
a
significant
global
health
issue.
While
Pap
smear
remains
reliable
method
for
early
detection,
identifying
new
biomarkers
to
stratify
the
risk
crucial.
For
this
purpose,
extensive
research
has
been
conducted
on
detecting
DNA
methylation.
(2)
Methods:
This
cross-sectional
study
aimed
assess
expression
levels
of
EIF4G3
and
SF3B1
in
precursor
lesions
cervical
tumor
tissues
through
qRT-PCR
evaluate
methylation
status
their
promoters
bisulfite
conversion.
(3)
Results:
Both
genes
showed
similar
mRNA
patterns,
with
highest
observed
squamous
cell
carcinoma
(SCC)
samples
(p
<
0.0001).
Additionally,
analysis
indicated
increased
percentages
control
group
both
factors.
Notably,
were
inversely
correlated
promoter
(EIF4G3—p
=
0.0016;
SF3B1—p
(4)
Conclusions:
Regarding
pattern
genes,
we
observe
decreasing
trend
from
NILM
SCC
patients.
Therefore,
concluded
that
decrease
at
level
could
be
an
indicator
abnormal
cytology.
Current Opinion in Obstetrics & Gynecology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Purpose
of
review
This
examines
Turkey's
cervical
cancer
screening
programme,
highlighting
its
evolution
from
a
cytology-based
approach
to
more
effective
HPV-based
strategy.
The
is
timely
given
the
global
push
reduce
incidence
through
improved
practices,
and
it
positions
programme
as
potential
model
for
other
countries
facing
similar
public
health
challenges.
Recent
findings
advances
in
Turkey
include
nationwide
introduction
HPV
DNA
testing,
centralized
laboratory
systems
innovative
management
software.
has
significantly
coverage
early
detection
rates,
particularly
underserved
communities.
However,
challenges
remain
areas
such
training
healthcare
workers,
raising
awareness
vaccination,
integrating
self-sampling
methods
into
process.
Summary
Turkish
experience
demonstrates
that
well
organized
can
overcome
significant
cultural
logistical
barriers
lead
outcomes.
Future
efforts
should
focus
on
refining
triage
strategies,
exploring
new
molecular
tests,
expanding
use
further
improve
effectiveness
prevention
worldwide.
