Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs DOI
M. Amélia Santos, Sérgio M. Marques, Sı́lvia Chaves

et al.

Coordination Chemistry Reviews, Journal Year: 2011, Volume and Issue: 256(1-2), P. 240 - 259

Published: Aug. 16, 2011

Language: Английский

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases DOI
Cristina Rodríguez‐Rodríguez, Maria A. Telpoukhovskaia, Chris Orvig

et al.

Coordination Chemistry Reviews, Journal Year: 2012, Volume and Issue: 256(19-20), P. 2308 - 2332

Published: March 21, 2012

Language: Английский

Citations

140
Alzheimer’s disease: How metal ions define β-amyloid function DOI
Kasper P. Kepp

Coordination Chemistry Reviews, Journal Year: 2017, Volume and Issue: 351, P. 127 - 159

Published: May 20, 2017

Language: Английский

Citations

134
Chelation therapy in Wilson's disease: from d-penicillamine to the design of selective bioinspired intracellular Cu(i) chelators DOI
Pascale Delangle,

Elisabeth Mintz

Dalton Transactions, Journal Year: 2012, Volume and Issue: 41(21), P. 6359 - 6359

Published: Jan. 1, 2012

Wilson's disease is an orphan due to copper homeostasis dysfunction. Mutations of the ATP7B gene induces impaired functioning a Cu-ATPase, Cu detoxification in liver and overload body. Indeed, even though essential element, which used as cofactor by many enzymes playing vital roles, it becomes toxic when excess promotes cytotoxic reactions leading oxidative stress. In this perspective, human first described order explain mechanisms promoting disease. We will see that main organ for distribution Nowadays treated life-long systemic chelation therapy, not satisfactory cases. Therefore design more selective efficient drugs great interest. A strategy specific chelators treat localized accumulation then be presented. particular we show how bioinorganic chemistry may help such novel taking inspiration from biological cell transporters.

Language: Английский

Citations

132
Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration DOI
David T. Dexter,

Sarah Statton,

C. Whitmore

et al.

Journal of Neural Transmission, Journal Year: 2010, Volume and Issue: 118(2), P. 223 - 231

Published: Dec. 16, 2010

Language: Английский

Citations

130
Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs DOI
M. Amélia Santos, Sérgio M. Marques, Sı́lvia Chaves

et al.

Coordination Chemistry Reviews, Journal Year: 2011, Volume and Issue: 256(1-2), P. 240 - 259

Published: Aug. 16, 2011

Language: Английский

Citations

120