A brainstem circuit controls cough-like airway defensive behaviors in mice DOI Open Access

Xiaoshan Xu,

Xiupeng Nie,

Weijia Zhang

et al.

Published: Dec. 6, 2024

The respiratory tract is subject to complex neural control for eupneic breathing and distinct airway defensive reflexes. Growing evidence has highlighted significant heterogeneity of airway-innervating vagal sensory neurons in mediating various functions, however, the central neuronal pathways circuits involved regulation remain less understood. Combining whole-body plethysmography (WBP), audio, video tracking access behaviors conscious animals, we developed a quantitative paradigm implementing mouse as model study cough-like behaviors. Using TRAP2 transgenic mice vivo fiber photometry, found that activity caudal spinal trigeminal nucleus (SP5C) strongly correlated with tussigen-evoked responses. Impairing synaptic outputs or chemogenetic inhibition SP5C effectively abolished these Optogenetic stimulation excitatory their projections ventral group (VRG) triggered robust without tussive stimuli. Notably, tonic elevation excitability caused spontaneous activities chronically mice. Together, our data provide strong previously unrecognized brainstem circuit controls

Language: Английский

The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla DOI
Caitlynn C. De Preter,

Mary M. Heinricher

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Language: Английский

Citations

8
Morphine-responsive neurons that regulate mechanical antinociception DOI
Michael P. Fatt, Ming-Dong Zhang, Jussi Kupari

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6712)

Published: Aug. 29, 2024

Opioids are widely used, effective analgesics to manage severe acute and chronic pain, although they have recently come under scrutiny because of epidemic levels abuse. While these compounds act on numerous central peripheral pain pathways, the neuroanatomical substrate for opioid analgesia is not fully understood. By means single-cell transcriptomics manipulation morphine-responsive neurons, we identified an ensemble neurons in rostral ventromedial medulla (RVM) that regulates mechanical nociception mice. Among these, forced activation or silencing excitatory RVM

Language: Английский

Citations

7
Temporomandibular disorders and mental health: shared etiologies and treatment approaches DOI Creative Commons

Jiamin Wan,

Jiu Lin,

Tingfeng Zha

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 12, 2025

The biopsychosocial model suggests that temporomandibular disorders (TMDs) often coexist with mental health disorders, particularly depression and anxiety, affecting a significant portion of the global population. interplay between TMDs contributes to complex comorbidity, perpetuating cycle mutual influence reinforcement. This review investigates neurobiological mechanisms epidemiological evidence supporting shared etiology exploring potential vulnerabilities bidirectional causal relationships. Shared may stem from genetic epigenetic predispositions, psychosocial factors, behavioral aspects. Inflammatory cytokines, neurotransmitters, neurotrophins, neuropeptides play pivotal roles in both peripheral central sensitization as well neuroinflammation. Brain imaging studies suggest exhibit overlapping brain regions indicative reward processing deficits anomalies within triple network model. Future research efforts are crucial for developing comprehensive understanding underlying confirming reciprocal effects disorders. provides valuable insights oral healthcare professionals, stressing importance optimizing treatment strategies individuals dealing concurrent issues through personalized, holistic, multidisciplinary approach.

Language: Английский

Citations

1
A brainstem circuit controls cough-like airway defensive behaviors in mice DOI Creative Commons

Xiaoshan Xu,

Xiupeng Nie,

Weijia Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

Abstract The respiratory tract is subject to complex neural control for eupneic breathing and distinct airway defensive reflexes. Growing evidence has highlighted significant heterogeneity of airway-innervating vagal sensory neurons in mediating various functions, however, the central neuronal pathways circuits involved regulation remain less understood. Combining whole-body plethysmography (WBP), audio, video tracking access behaviors conscious animals, we developed a quantitative paradigm implementing mouse as model study cough-like behaviors. Using TRAP2 transgenic mice vivo fiber photometry, found that activity caudal spinal trigeminal nucleus (SP5C) strongly correlated with tussigen-evoked responses. Impairing synaptic outputs or chemogenetic inhibition SP5C effectively abolished these Optogenetic stimulation excitatory their projections ventral group (VRG) triggered robust without tussive stimuli. Notably, tonic elevation excitability caused spontaneous activities chronically mice. Together, our data provide strong previously unrecognized brainstem circuit controls

Language: Английский

Citations

0
A brainstem circuit controls cough-like airway defensive behaviors in mice DOI Open Access

Xiaoshan Xu,

Xiupeng Nie,

Weijia Zhang

et al.

Published: Dec. 6, 2024

The respiratory tract is subject to complex neural control for eupneic breathing and distinct airway defensive reflexes. Growing evidence has highlighted significant heterogeneity of airway-innervating vagal sensory neurons in mediating various functions, however, the central neuronal pathways circuits involved regulation remain less understood. Combining whole-body plethysmography (WBP), audio, video tracking access behaviors conscious animals, we developed a quantitative paradigm implementing mouse as model study cough-like behaviors. Using TRAP2 transgenic mice vivo fiber photometry, found that activity caudal spinal trigeminal nucleus (SP5C) strongly correlated with tussigen-evoked responses. Impairing synaptic outputs or chemogenetic inhibition SP5C effectively abolished these Optogenetic stimulation excitatory their projections ventral group (VRG) triggered robust without tussive stimuli. Notably, tonic elevation excitability caused spontaneous activities chronically mice. Together, our data provide strong previously unrecognized brainstem circuit controls

Language: Английский

Citations

0
A brainstem circuit controls cough-like airway defensive behaviors in mice DOI Open Access

Xiaoshan Xu,

Xiupeng Nie,

Weijia Zhang

et al.

Published: Dec. 6, 2024

The respiratory tract is subject to complex neural control for eupneic breathing and distinct airway defensive reflexes. Growing evidence has highlighted significant heterogeneity of airway-innervating vagal sensory neurons in mediating various functions, however, the central neuronal pathways circuits involved regulation remain less understood. Combining whole-body plethysmography (WBP), audio, video tracking access behaviors conscious animals, we developed a quantitative paradigm implementing mouse as model study cough-like behaviors. Using TRAP2 transgenic mice vivo fiber photometry, found that activity caudal spinal trigeminal nucleus (SP5C) strongly correlated with tussigen-evoked responses. Impairing synaptic outputs or chemogenetic inhibition SP5C effectively abolished these Optogenetic stimulation excitatory their projections ventral group (VRG) triggered robust without tussive stimuli. Notably, tonic elevation excitability caused spontaneous activities chronically mice. Together, our data provide strong previously unrecognized brainstem circuit controls

Language: Английский

Citations

0