Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in Caenorhabditis elegans
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(1), P. 78 - 78
Published: Jan. 10, 2025
Lipid
metabolism
plays
a
critical
role
in
maintaining
cellular
integrity,
especially
within
the
nervous
system,
where
lipids
support
neuronal
structure,
function,
and
synaptic
plasticity.
However,
this
essential
metabolic
pathway
is
highly
susceptible
to
oxidative
stress,
which
can
lead
lipid
peroxidation,
damaging
process
induced
by
reactive
oxygen
species.
peroxidation
generates
by-products
that
disrupt
many
functions,
with
strong
impact
on
proteostasis.
In
review,
we
explore
of
oxidation
protein
folding
its
associated
pathological
implications,
particular
focus
findings
neurodegeneration
from
Caenorhabditis
elegans
studies,
an
animal
model
remains
underutilized.
Additionally,
highlight
effectiveness
different
methodologies
applied
nematode
deepen
our
understanding
intricate
process.
system
any
animal,
including
mammals
invertebrates,
disturb
delicate
balance
homeostasis,
leading
build-up
toxic
by-products,
misfolding,
key
factors
neurodegenerative
diseases.
This
disruption
contributes
pathogenesis
disorders
such
as
Alzheimer's,
Parkinson's,
or
Huntington's
disease.
The
studies
offer
valuable
insights
into
these
complex
processes
potential
avenues
for
developing
targeted
therapies
mitigate
disease
progression.
Language: Английский
Caenorhabditis elegans endorse bacterial nanocellulose fibers as functional dietary Fiber reducing lipid markers
Carbohydrate Polymers,
Journal Year:
2024,
Volume and Issue:
331, P. 121815 - 121815
Published: Jan. 15, 2024
Bacterial
nanocellulose
(BNC)
is
a
promising
dietary
fiber
with
potential
as
functional
food
additive.
We
evaluated
BNC
fibers
(BNCf)
in
the
Caenorhabditis
elegans
model
to
obtain
insight
into
BNCf's
biointeraction
its
gastrointestinal
tract
while
reducing
variables
of
higher
complex
animals.
BNCf
were
uptaken
and
excreted
by
worms
without
crossing
intestinal
barrier,
confirming
biosafety
regarding
survival
rate,
reproduction,
aging
for
concentrations
up
34
μg/ml
BNCf.
However,
slight
decrease
worms'
length
was
detected.
A
possible
nutrient
shortage
or
stress
produced
discarded
measuring
chemotactic
response
pathways.
Besides,
we
detected
lipid-lowering
effect
N2
C.
normal
high-caloric
diets.
Oxidative
damage
computed
Rac1/ced-10
mutants.
The
GTPase
Rac1
involved
neurological
diseases,
where
dysregulation
enhances
ROS
production
neuronal
damage.
reduced
lipid
oxidative
markers
species
this
worm
strain.
Finally,
that
activated
genetic
expression
immunological
catabolic
process.
These
results
strengthen
use
encourage
treatment
disease
modulating
diet.
Language: Английский
The role of amphipathic and cationic helical peptides in Parkinson's disease
Protein Science,
Journal Year:
2024,
Volume and Issue:
34(1)
Published: Dec. 25, 2024
Abstract
Peptides
are
attracting
a
growing
interest
for
therapeutic
applications
in
biomedicine.
In
Parkinson's
disease
(PD),
different
human
endogenous
peptides
have
been
associated
with
beneficial
effects,
including
protein
aggregation
inhibition,
reduced
inflammation,
or
the
protection
of
dopaminergic
neurons.
Such
effects
seem
to
be
connected
spatial
arrangement
peptide
side
chains,
and
many
these
molecules
share
common
conformational
traits,
displaying
distinctive
amphipathic
cationic
helical
structure,
which
is
believed
crucial
their
activities.
This
review
delves
into
relationship
between
structural
properties
current
evidence
connecting
biogenic
amelioration
PD
symptoms.
We
discuss
implications
disease,
mechanisms
action,
state
validation,
potential.
Language: Английский