LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents DOI
Maximilian Tufvesson‐Alm, Cajsa Aranäs,

Sebastian Blid Sköldheden

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Abstract The underlying neurobiology of alcohol use disorder (AUD) is complex and needs further unraveling, with one the key mechanisms being gut-brain peptide ghrelin its receptor (GHSR). However, additional substrates pathway, such as liver-expressed antimicrobial 2 (LEAP2), an endogenous GHSR inverse agonist, may contribute to this neurobiological framework. While LEAP2 modulates feeding reward through central mechanisms, effects on responses are unknown. aim present study was therefore identify impact ability activate mesolimbic dopamine system define control intake. These experiments revealed that (i.e. into third ventricle) prevented cause locomotor stimulation in male mice, suppressed memory attenuated release nucleus accumbens caused by alcohol. Moreover, reduced consumption both female rats exposed for 6 weeks before treatment. On contrary, serum levels were similar between high- low- alcohol-consuming (male) rats. Furthermore, lowered food intake body weight females. Collectively, mitigates alcohol-related rodents, contributing our understanding pathway's role effects.

Language: Английский

LEAP2 in Physiology—A Narrative Review DOI Open Access

Oskar Sosinski,

Ewa Pruszyńska‐Oszmałek, Natalia Leciejewska

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 377 - 377

Published: Jan. 4, 2025

Liver Enriched Antimicrobial Peptide 2 (LEAP2) is a fascinating peptide that has gained significant attention since its discovery in 2003. Initially identified as an antimicrobial peptide, LEAP2 more recently been found to play key role the regulation of energy metabolism. One most notable functions interaction with ghrelin hormone, which known for stimulating hunger. acts inhibitor ghrelin, thereby reducing food intake and influencing balance. The physiological roles extend beyond appetite suppression. Studies have shown impact on insulin secretion, suggesting potential involvement glucose metabolism possibly sensitivity, crucial managing conditions like type diabetes. Moreover, levels appear fluctuate based factors such gender, developmental stage, even interventions bariatric surgery, obesity Given these findings, shows therapeutic target, particularly addressing metabolic diseases Its ability influence balance makes it promising candidate further research into therapies aimed at weight glycemic control. In future, could become important agent development treatments curbing associated disorders.

Language: Английский

Citations

0
An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress DOI
Alexis A. Salcido,

Neftali F. Reyes,

Andrea Y. Macias

et al.

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 205 - 227

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Connection Between the Appetite-Regulatory Peptides Ghrelin and GLP-1 and Alcohol Use Disorder DOI
Elisabet Jerlhag

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 229 - 241

Published: Jan. 1, 2025

Language: Английский

Citations

0
LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents DOI Creative Commons
Maximilian Tufvesson‐Alm, Cajsa Aranäs,

Sebastian Blid Sköldheden

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 2, 2024

Language: Английский

Citations

3
LEAP2, a ghrelin receptor inverse agonist, and its effect on alcohol-related responses in rodents DOI
Maximilian Tufvesson‐Alm, Cajsa Aranäs,

Sebastian Blid Sköldheden

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Abstract The underlying neurobiology of alcohol use disorder (AUD) is complex and needs further unraveling, with one the key mechanisms being gut-brain peptide ghrelin its receptor (GHSR). However, additional substrates pathway, such as liver-expressed antimicrobial 2 (LEAP2), an endogenous GHSR inverse agonist, may contribute to this neurobiological framework. While LEAP2 modulates feeding reward through central mechanisms, effects on responses are unknown. aim present study was therefore identify impact ability activate mesolimbic dopamine system define control intake. These experiments revealed that (i.e. into third ventricle) prevented cause locomotor stimulation in male mice, suppressed memory attenuated release nucleus accumbens caused by alcohol. Moreover, reduced consumption both female rats exposed for 6 weeks before treatment. On contrary, serum levels were similar between high- low- alcohol-consuming (male) rats. Furthermore, lowered food intake body weight females. Collectively, mitigates alcohol-related rodents, contributing our understanding pathway's role effects.

Language: Английский

Citations

0