Comparison of Neutrophil-to-Lymphocyte (NLR) Ratio in Affective vs Non-affective Psychosis DOI Creative Commons
Beyazıt Garip,

Begüm Oğur,

S. Tekin

et al.

Genel Tıp Dergisi, Journal Year: 2024, Volume and Issue: 34(5), P. 624 - 628

Published: Oct. 8, 2024

Objective: An elevated level of NLR is defined as an indicator systemic inflammation, and it stated that can be used effective tool in navigating psychosis. The aim the present study to explore blood parameters such neutrophil, lymphocyte, monocyte their ratios (NLR, MLR, PLR) both affective non-affective Materials Methods: This a retrospective case-control conducted on schizophrenia(Sch), first-episode psychosis(FEP), bipolar disorder(BD). Digital medical records were retrospectively analyzed between 2016 2021. total number patients recruited for this 437. Patients divided into 3 groups which are schizophrenia (n:199), FEP (n:127), Bipolar Disorder (n:111). healthy control (HC) group (n:200) was selected who had never been diagnosed with any psychiatric disorders. Results: In study, no difference found patient terms substance use (Chi-square= 5.008; p= 0.082), platelet count lower SCH other count. There statistical counts (p>0.05 each). Conclusion: contrast previous findings, we did not show significant differences NLR, PLR levels To better understand pathophysiology psychosis, might more suitable conduct clinical trial drug-naive prospective manner.

Language: Английский

Complete blood count-based inflammation indexes and symptom severity in people with schizophrenia spectrum disorders: An analysis based on structural equation modelling DOI Creative Commons
Daniele Cavaleri, Aldo De Pietra,

Marco Gazzola

et al.

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 168, P. 107134 - 107134

Published: July 14, 2024

Schizophrenia spectrum disorders (SSDs) are associated with immune-inflammatory activation. Recently, complete blood count (CBC)-based inflammation indexes such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) have emerged reproducible cost-effective markers in mental disorders. In this study, we aimed at investigating relationship of NLR, MLR, PLR symptom severity people SSDs, testing interactions relevant clinical variables.

Language: Английский

Citations

3
Neutrophil/lymphocyte ratio and cognitive performances in first-episode patients with schizophrenia and healthy controls DOI

Jing Liang,

Xiaoni Guan,

Qianqian Sun

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 135, P. 111092 - 111092

Published: July 17, 2024

Language: Английский

Citations

2
Onset age moderates the associations between neutrophil-to-lymphocyte ratio and clinical symptoms in first-episode patients with schizophrenia DOI Creative Commons
Kongxiang Wang, Shaohua Liu, Dan Huang

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 19, 2024

Patients with schizophrenia early onset age have been shown to exhibit more severe negative symptoms. Genetic, biomarker, postmortem brain, and imaging studies indicate the involvement of immune abnormalities in pathophysiology schizophrenia. In this study, we examined moderating role on associations between clinical symptoms neutrophil-to-lymphocyte ratio (NLR) medication-naïve first-episode (MNFES). A total 97 MNFES patients were recruited. Neutrophil (NEU), LYM, NLR values compared early-onset (EO) non-early-onset (non-EO) explore potential influence EO correlations The results showed no differences NEU non-EO groups. group, significantly correlated general psychopathology score (all p < 0.05), whereas lymphocyte counts not associated group. Linear regression analysis group revealed that or a predictive biomarker for Our study indicates had greater patients. addition, mediates relationships symptoms, suggesting an disturbance, particularly increased innate response patients, may be involved psychophysiology

Language: Английский

Citations

1
Comparison of Neutrophil-to-Lymphocyte (NLR) Ratio in Affective vs Non-affective Psychosis DOI Creative Commons
Beyazıt Garip,

Begüm Oğur,

S. Tekin

et al.

Genel Tıp Dergisi, Journal Year: 2024, Volume and Issue: 34(5), P. 624 - 628

Published: Oct. 8, 2024

Objective: An elevated level of NLR is defined as an indicator systemic inflammation, and it stated that can be used effective tool in navigating psychosis. The aim the present study to explore blood parameters such neutrophil, lymphocyte, monocyte their ratios (NLR, MLR, PLR) both affective non-affective Materials Methods: This a retrospective case-control conducted on schizophrenia(Sch), first-episode psychosis(FEP), bipolar disorder(BD). Digital medical records were retrospectively analyzed between 2016 2021. total number patients recruited for this 437. Patients divided into 3 groups which are schizophrenia (n:199), FEP (n:127), Bipolar Disorder (n:111). healthy control (HC) group (n:200) was selected who had never been diagnosed with any psychiatric disorders. Results: In study, no difference found patient terms substance use (Chi-square= 5.008; p= 0.082), platelet count lower SCH other count. There statistical counts (p&gt;0.05 each). Conclusion: contrast previous findings, we did not show significant differences NLR, PLR levels To better understand pathophysiology psychosis, might more suitable conduct clinical trial drug-naive prospective manner.

Language: Английский

Citations

0