Progress in the application of novel inflammatory indicators in chronic kidney disease

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Chronic kidney disease has become a public health problem endangering the of all humans because its high prevalence, mortality and medical burden. The chronic micro-inflammatory state is recognized as significant component CKD, playing key role in progression. Intervening inflammation during course can enhance prognosis. Recent studies have demonstrated that novel inflammatory indices, such neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte systemic immune-inflammatory index are closely associated with meanwhile may serve prognostic monitors all-cause death poor renal prognosis for disease. This article comprehensively reports on mechanisms micro-inflammation relationship between indicators their impact

Language: Английский

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Observations on the efficacy of edaravone dexborneol in preventing post-stroke depression and its inflammatory mechanism: a prospective, randomized, control trial

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 9, 2024

This study aimed to observe the effect of edaravone dexborneol (EDB) on incidence early post-stroke depression (PSD) and explore its inflammatory mechanisms.

Language: Английский

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EEG microstate as a biomarker of post-stroke depression with acupuncture treatment

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 29, 2024

Post-stroke depression (PSD) is a prevalent psychiatric complication among stroke survivors. The PSD researches focus on pathogenesis, new treatment methods and efficacy prediction. This study explored the electroencephalography (EEG) microstates in assessed their changes after acupuncture treatment, aiming to find biological characteristics predictors of PSD.

Language: Английский

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New insights into roles of IL-7R gene as a diagnostic biomarker for post-stroke depression

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 23, 2024

Background Post-stroke depression (PSD) is the most prevalent neuropsychiatric complication following a stroke. The inflammatory theory suggests that PSD may be associated with an overactive response. However, research findings regarding inflammation-related indicators in remain inconsistent and elusive. This study aimed to screen diagnostic markers helps distinguish between post-stroke non-depressed (PSND) patients. Methods Two GEO datasets, including patients major disease (MDD) controls (CON, GSE98793), ischemic stroke (IS) CON (GSE16561), were used analyzed differentially expressed genes (DEGs) perform enrichment analysis. Protein-protein interaction (PPI) network Random Forest analysis candidate hub genes. CIBERSORT was performed analyze immune infiltration. We proteins interact using string database, circRNA-miRNA-mRNA ceRNA of RNAInter, miRWalk, miRDB Starbase databases, drugs regulate by DSigDB database. further verified expression Quantitative Real-Time PCR from blood CON. Results From screened 394 DEGs, DEGs found primarily related activation PPI random forest obtained genes: IL-7R. ROC showed IL-7R had good predictive effect on MDD IS proportions macrophages M0 monocytes significantly higher than those constructed perturbagen signatures computational drug can target MDD, PSND lower CON, Conclusion These indicate serve as marker patients, targeting therapeutic could potentially improve treatment outcomes for PSD.

Language: Английский

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The neuroimmune mechanism of pain induced depression in psoriatic arthritis and future directions

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 182, P. 117802 - 117802

Published: Dec. 31, 2024

Patients suffering from psoriatic arthritis (PsA) often experience depression due to chronic joint pain, which significantly hinders their recovery process. However, the relationship between these two conditions is not well understood. Through a review of existing studies, we revealed that certain neuroendocrine hormones and neurotransmitters are involved in neuroimmune interactions related both PsA depression. These include adrenocorticotropin-releasing hormone (CRH), adrenocorticotropin (ACTH), cortisol, monoamine neurotransmitters, brain-derived neurotrophic factor (BDNF). Notably, signalling pathway involving CRH, MCs, Th17 cells plays crucial role linking with depression; thus, this may help clarify connection. In review, outline inflammatory immune changes associated Additionally, explore how influence responses conditions. Finally, our focus will be on potential treatment strategies for patients through targeting CRH-MC-Th17 pathway. This aims provide theoretical framework as new therapeutic targets managing alongside

Language: Английский

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