Drugs Used in “Chemsex”/Sexualized Drug Behaviour—Overview of the Related Clinical Psychopharmacological Issues DOI Creative Commons
Fabrizio Schifano,

Stefania Bonaccorso,

Davide Arillotta

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 424 - 424

Published: April 22, 2025

Background: “Chemsex” involves the intake of a range drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL), ketamine, methamphetamine, “poppers”, type V phosphodiesterase (PDE) inhibitors, MDMA/ecstasy, cocaine, cannabis, and occasionally few other molecules as well, to enhance prolong sexual experiences. This paper aims provide an overview clinical pharmacology vast that are being used for chemsex with focus on both medical psychopathological disturbances they can produce. Methods: A narrative literature review was conducted using Pubmed, Scopus, Web Science databases. total 273 papers published up January 2025 were screened; articles selected based relevance chemsex/sexualized behaviour related substances. Both human preclinical studies considered. Results: The use stimulants is likely need increase much possible arousal performance but also social interactions. Furthermore, empathogenic/entactogenic activities some MDMA-like “love drugs” facilitate occurrence “feeling closer/more intimate” emotional sensations, GHB/GBL may user subjective sensation disinhibition, hence facilitating condomless meetings higher number random partners. Conversely, ketamine be enjoy its psychotropic dissociative characteristics potentially painful receptive anal intercourse and/or fisting Most typically, these consumed in combination, polydrug exposure possibly serotonergic syndrome, seizures, drug–drug pharmacokinetics’ interaction, sympathomimetic overstimulation. Following exposures, conditions have at times been reported. These issues lead misuse opiates/opioids, gabapentinoids, antipsychotics. Conclusions: Further actions should aim reducing stigma prevents individuals from accessing necessary healthcare support services. multidisciplinary approach combines medical, psychological, remains key managing complex challenges posed by chemsex-related drug use.

Language: Английский

The rapid onset of response to depression treatment by Yueju Pill: from discovery of a novel treatment target to clinical perspective DOI Creative Commons
Ruiyi Liu,

Zhangjie Wu,

Ying Yin

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: unknown, P. 100121 - 100121

Published: April 1, 2025

Language: Английский

Citations

1
Drugs Used in “Chemsex”/Sexualized Drug Behaviour—Overview of the Related Clinical Psychopharmacological Issues DOI Creative Commons
Fabrizio Schifano,

Stefania Bonaccorso,

Davide Arillotta

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 424 - 424

Published: April 22, 2025

Background: “Chemsex” involves the intake of a range drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL), ketamine, methamphetamine, “poppers”, type V phosphodiesterase (PDE) inhibitors, MDMA/ecstasy, cocaine, cannabis, and occasionally few other molecules as well, to enhance prolong sexual experiences. This paper aims provide an overview clinical pharmacology vast that are being used for chemsex with focus on both medical psychopathological disturbances they can produce. Methods: A narrative literature review was conducted using Pubmed, Scopus, Web Science databases. total 273 papers published up January 2025 were screened; articles selected based relevance chemsex/sexualized behaviour related substances. Both human preclinical studies considered. Results: The use stimulants is likely need increase much possible arousal performance but also social interactions. Furthermore, empathogenic/entactogenic activities some MDMA-like “love drugs” facilitate occurrence “feeling closer/more intimate” emotional sensations, GHB/GBL may user subjective sensation disinhibition, hence facilitating condomless meetings higher number random partners. Conversely, ketamine be enjoy its psychotropic dissociative characteristics potentially painful receptive anal intercourse and/or fisting Most typically, these consumed in combination, polydrug exposure possibly serotonergic syndrome, seizures, drug–drug pharmacokinetics’ interaction, sympathomimetic overstimulation. Following exposures, conditions have at times been reported. These issues lead misuse opiates/opioids, gabapentinoids, antipsychotics. Conclusions: Further actions should aim reducing stigma prevents individuals from accessing necessary healthcare support services. multidisciplinary approach combines medical, psychological, remains key managing complex challenges posed by chemsex-related drug use.

Language: Английский

Citations

0