Functional Alterations in Gray Matter Networks Mediated by White Matter During the Aging Process DOI
Jianxi Liu,

M. Huang,

Kang Hu

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(2)

Published: March 1, 2025

ABSTRACT Background and Purpose Extensive research has been carried out to investigate changes in various gray matter (GM) regions during the aging process using resting‐state functional MRI. However, impact of on connectivity (FC) between white (WM) GM, particularly matter–gray (WM–GM FC), remains largely unknown. This study proposes a novel method for constructing networks that integrate both WM GM. Methods By utilizing data from lifespan cohort 439 healthy adults, we devised covariance‐based approach establish matter–white (GM–WM–GM) mediated network. The FC GM was quantified Johns Hopkins University International Consortium Brain Mapping‐Diffusion Tensor Imaging‐81 atlas combination with Automated Anatomical Labeling atlas. First, WM–GM calculated via Pearson correlation coefficients regions, followed by standardization resulting matrix. GM–WM–GM then constructed covariance Furthermore, topological properties were networks. Finally, age effect its topology explored. Results Our findings reveal significant age‐related decline intranetwork global network efficiency, while internetwork an inverted U‐shaped pattern, suggesting dedifferentiation brain. Despite relatively stable local observed reduction efficiency indicates weakening long‐range neural connections. Additionally, decrease modularity further supports this trend. Conclusion These results offer insights into age‐associated reorganization brain networks, enhancing our understanding mechanisms underlying normal aging.

Language: Английский

Functional Alterations in Gray Matter Networks Mediated by White Matter During the Aging Process DOI
Jianxi Liu,

M. Huang,

Kang Hu

et al.

Journal of Neuroimaging, Journal Year: 2025, Volume and Issue: 35(2)

Published: March 1, 2025

ABSTRACT Background and Purpose Extensive research has been carried out to investigate changes in various gray matter (GM) regions during the aging process using resting‐state functional MRI. However, impact of on connectivity (FC) between white (WM) GM, particularly matter–gray (WM–GM FC), remains largely unknown. This study proposes a novel method for constructing networks that integrate both WM GM. Methods By utilizing data from lifespan cohort 439 healthy adults, we devised covariance‐based approach establish matter–white (GM–WM–GM) mediated network. The FC GM was quantified Johns Hopkins University International Consortium Brain Mapping‐Diffusion Tensor Imaging‐81 atlas combination with Automated Anatomical Labeling atlas. First, WM–GM calculated via Pearson correlation coefficients regions, followed by standardization resulting matrix. GM–WM–GM then constructed covariance Furthermore, topological properties were networks. Finally, age effect its topology explored. Results Our findings reveal significant age‐related decline intranetwork global network efficiency, while internetwork an inverted U‐shaped pattern, suggesting dedifferentiation brain. Despite relatively stable local observed reduction efficiency indicates weakening long‐range neural connections. Additionally, decrease modularity further supports this trend. Conclusion These results offer insights into age‐associated reorganization brain networks, enhancing our understanding mechanisms underlying normal aging.

Language: Английский

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