Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 801 - 801
Published: Feb. 9, 2025
Iridium complexes attract a lot of attention as highly promising antitumor agents due to their various structures, which offer the modification physicochemical and biological effects. Compared conventional platinum-based drugs, iridium are commonly thought be more active in tumors, resistant platinum stable air moisture conditions. Chloridoiridium range advantages facilitating rational design, reactivity photochemical activity, leading different cytotoxic profiles, diverse mechanisms action specific intracellular organelles targets. They also known good light-mediated chemotherapeutics, serving bioimaging biosensing agents. The potential photophysical properties chloridoiridium(III) can readily controlled by suitable ligand modifications substitution patterns, providing wide versatile structures. Over years, numerous structural types chloridoiridium have been developed studied for antineoplastic activity. In this review, recent advances cytotoxicity studies compounds summarized. categorized review according number coordinated ligands, type donor atoms, nuclearity complexes, etc., allowing thorough discussion structure-activity relationship.
Language: Английский