Poly(1,4,5-oxadithiepan-2-one)-Based Redox and pH Dual-Responsive Polyzwitterionic Micelles for Tumor Cell-Targeted Drug Delivery

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

Study of Manipulative In Situ Pore‐Formation upon Polymeric Coating on Cylindrical Substrate for Sustained Drug Delivery

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown

Published: July 22, 2024

Abstract Herein, the micro‐porous polylactic acid coating applied on surface of cylindrical substrate is fabricated by a novel in situ pore‐formation strategy based combinational effect breath figure (BF) and vapor‐induced phase separation (VIPS) processes. Under condition high environmental humidity, solvent pair chloroform dimethylformamide employed for post‐treatment onto pre‐formed PLA to induce following mechanism BF VIPS, respectively. A composite porous structure with both cellular‐like bi‐continuous network morphologies obtained. By tunning experimental factors including ratio pair, temperature, morphological manipulation upon pore morphology can be facilely achieved control transition between VIPS. Paclitaxel used as model drug loaded into wicking post‐immersion. Coatings different features show varying loading release capacities. The 28‐day test reveals dynamic profiles samples, total rate ranging from 35.70% 79.96%. Optimal capacity 19.28 µg cm −2 are BF‐VIPS structure. This research established cost‐efficient flexibility structural concerning construction drug‐eluting feature manipulative delivery.

Language: Английский

Folic Acid Conjugated Sodium Alginate based Redox Responsive Smart Functional Microgels As A Potential Targeted Anticancer Drug Carrier

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106372 - 106372

Published: Nov. 1, 2024

Language: Английский