The Cutting Edge Quest: Epic Saga of Carboxymethyl Guar Gum in Drug Delivery and Roads Ahead DOI

Vaishali Thakur,

Sonia Dhiman,

Thakur Gurjeet Singh

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT The search for novel drug delivery systems has generated great interest in biopolymer‐based carriers. Among these, carboxymethyl guar gum (CMGG) been shown to be promising. CMGG is a chemically modified derivative of that synthesized by carboxymethylation with monochloroacetic acid and sodium hydroxide under optimized conditions. This improves the physicochemical properties polysaccharide, which are enhanced hydrophilicity, viscosity, swelling behavior compared unmodified Guar gum. review focuses on wide applications systems, thus underlining its versatility as an excipient based unique properties. Key features such pseudoplasticity allow effective drugs controlled‐release systems. Advanced characterization techniques, like Fourier Transform Infrared Spectroscopy Nuclear Magnetic Resonance (NMR) spectroscopy, confirm structural changes due carboxymethylation; further aspects emphasized rheological studies, highlight applicability pharmaceutical fields. biocompatibility biodegradability add advantages, offering safety compatibility environment therapeutic applications. capacity enclose hydrophilic well control release profiles shows promise efficacy enhancement patient safety. puts forward represents excellent means development enhancing outcomes.

Language: Английский

Development of a thiol-maleimide crosslinked carboxymethyl guar gum hydrogel for sustained drug delivery DOI
Rua B. Alnoman, Hussam Y. Alharbi,

Majed S. Aljohani

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106633 - 106633

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Cutting Edge Quest: Epic Saga of Carboxymethyl Guar Gum in Drug Delivery and Roads Ahead DOI

Vaishali Thakur,

Sonia Dhiman,

Thakur Gurjeet Singh

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT The search for novel drug delivery systems has generated great interest in biopolymer‐based carriers. Among these, carboxymethyl guar gum (CMGG) been shown to be promising. CMGG is a chemically modified derivative of that synthesized by carboxymethylation with monochloroacetic acid and sodium hydroxide under optimized conditions. This improves the physicochemical properties polysaccharide, which are enhanced hydrophilicity, viscosity, swelling behavior compared unmodified Guar gum. review focuses on wide applications systems, thus underlining its versatility as an excipient based unique properties. Key features such pseudoplasticity allow effective drugs controlled‐release systems. Advanced characterization techniques, like Fourier Transform Infrared Spectroscopy Nuclear Magnetic Resonance (NMR) spectroscopy, confirm structural changes due carboxymethylation; further aspects emphasized rheological studies, highlight applicability pharmaceutical fields. biocompatibility biodegradability add advantages, offering safety compatibility environment therapeutic applications. capacity enclose hydrophilic well control release profiles shows promise efficacy enhancement patient safety. puts forward represents excellent means development enhancing outcomes.

Language: Английский

Citations

0