In vitro antioxidant and anticancer potential of intra-cellular ethyl acetate extract of marine-derived fungus Talaromyces tratensis SS10 DOI Open Access
Samah Shabana,

Rachakonda Bhargavi,

A. Krishna Satya

et al.

Journal of Phytology, Journal Year: 2024, Volume and Issue: unknown, P. 98 - 105

Published: May 15, 2024

Marine fungi are well-known for producing structurally distinct secondary metabolites, making them potential sources of novel therapies. The present investigation aims to study the in vitro antioxidant and anticancer intra-cellular crude ethyl acetate extracts Talaromyces tratensis SS10. In study, qualitative quantitative phytochemical studies various solvent T. have been carried out using standard protocols. Later, extract was analyzed phytochemicals Gas Chromatography Mass Spectrometry (GC-MS). Further, properties done by Ferric reducing power assay (FRAP). this has MTT against human cancer cells such as MDA MB 231, HeLa, HT-29. Ethyl exhibited a higher yield chemical extraction than other solvents used. GCMS analysis revealed major phytoconstituents N-(1,1-Dimethylpropyl)-2,2,3-trimethylaziridine-1-carboxamide, 1-Undecanol, 5,5 Dimethyl-3-vinyl cyclohex-2-en-1-one, 1,2-Benzenedicarboxylic acid, bis (2-methyl propyl) ester. showed highest percentage Fe3+ reduction (48.093±1.469%) at 120 μg/mL, with an IC50 value 157.26 μg/mL concentration. Furthermore, 100 significant cell death rates cytotoxic assays, indicating low viable all three examined lines. shown dose-dependent effect tested better (6.25 μg/mL) recorded case HeLa lines followed 12.5 both 231 HT-29 presence bioactive compounds Benzeneethanamine, N-[(pentafluorophenyl)methylene]-beta.,3,4-tris[(trimethylsilyl) oxy]-, bis(2-methylpropyl) ester, cyclononasiloxane, octadecamethyl- may contributed extracts’ strong properties. current study’s findings show that SS10 drug development due its constituents, which possess biological activities.

Language: Английский

Development and evaluation of hyaluronic acid-coated chitosan nanoparticles for improved delivery of sorafenib tosylate in the treatment of hepatocellular carcinoma DOI
Putrevu Sreelaya, Sankha Bhattacharya, Darshan Bhirud

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 25, 2025

Language: Английский

Citations

2
Assessment of Anticancer Properties of Thai Plants DOI
Bancha Yingngam

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 122 - 164

Published: March 11, 2024

Cancer, a critical health concern, necessitates safer, more effective treatments. This chapter explores the anticancer potential of traditional Thai plants, which, despite being underresearched, show significant promise. It focuses on bioactive compounds and their efficacy against various cancer types. The categorizes these plants based active components reviews both laboratory animal studies to understand underlying mechanisms involved in inhibiting cell growth, inducing death, preventing tumor blood vessel formation. Clinical trials supporting findings are also highlighted. Given improve or innovate treatments, present encouraging prospects. However, further research is essential confirm safety approaches. These suggest that could lead development innovative drugs, signaling advancements therapy.

Language: Английский

Citations

13
Nutritional, Phytochemical, and Antimicrobial Properties of Carica papaya Leaves: Implications for Health Benefits and Food Applications DOI Creative Commons

Rajni Choudhary,

Ravinder Kaushik, Ansab Akhtar

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 154 - 154

Published: Jan. 7, 2025

Papaya leaves (PLs) are known for their therapeutic benefits and traditional use in treating inflammation, infections, various health conditions. Rich bioactive compounds, PLs studied potential applications functional foods. This study analyzed nutritional, phytochemical, structural, thermal, antimicrobial properties to evaluate role as a health-promoting ingredient. Phytochemicals were quantified spectrophotometrically identified via GC-MS. Antioxidant activity was assessed using DPPH FRAP assays. Mineral content determined ICP-OES. Structural thermal evaluated FTIR, XRD, calorimetry, tested the agar well diffusion method. contained 25.75% crude protein, 41.49% carbohydrates, high levels of flavonoids (21.00 mg QE/g), phenolics (8.85 GAE/g), tannins (430 TAE/g). assays confirmed strong free radical scavenging potential. analysis showed abundant K, Ca, Mg, Na, Fe (4071, 1079, 789.2, 361.2, 228.2 mg/kg, respectively). revealed groups, 23.9% crystallinity, degradation characteristics. exhibited activity, inhibiting E. coli, S. aureus, B. subtilis, K. pneumoniae with zones 22.05-25.15 mm. demonstrate antioxidant, properties, supporting inclusion food.

Language: Английский

Citations

1
Antidiabetic activities of aerial part of Asparagus racemosus Willd. extract: an in vitro, in vivo, and in silico approach DOI

Priya Das,

Ankrita Thapa,

Suraj Mistri

et al.

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Abstract Asparagus racemosus Willd., a significant medicinal plant in India’s Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of aerial part Willd. utilizing streptozotocin-nicotinamide-induced diabetic rat model. methanolic extract (ARME) was evaluated for vitro activity through α-glucosidase and α-amylase enzyme suppression assay assessed vivo streptozotocin-induced A 21-day chronic multiple-dose ARME examined. STZ-induced rats were treated with metformin (70 mg/kg) at concentrations 200 400 mg/kg. It discovered that inhibited activities showed potent therapeutic effects on rat’s helps raise body weight, hemoglobin, other blood counts normalizes serum parameters group. In addition, liver tissues’ abnormal levels antioxidant enzymes glutathione lipid peroxides returned those control animals. HPTLC revealed presence stigmasterol, which strong affinity proteins linked diabetes mellitus silico study. As result these findings, inhibits digestive has antihyperglycemic STZ-nicotinamide-induced rats.

Language: Английский

Citations

0
Combating HTLV-1 infections with Taxus baccata phytoconstituents: Molecular mechanisms potential anti-ATLL agents DOI

A R Akbarzadeh Baghban,

Seyed Abdolrahim Rezaee, Mohsen Tafaghodi

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 4, P. 100036 - 100036

Published: April 16, 2024

Language: Английский

Citations

0
In vitro antioxidant and anticancer potential of intra-cellular ethyl acetate extract of marine-derived fungus Talaromyces tratensis SS10 DOI Open Access
Samah Shabana,

Rachakonda Bhargavi,

A. Krishna Satya

et al.

Journal of Phytology, Journal Year: 2024, Volume and Issue: unknown, P. 98 - 105

Published: May 15, 2024

Marine fungi are well-known for producing structurally distinct secondary metabolites, making them potential sources of novel therapies. The present investigation aims to study the in vitro antioxidant and anticancer intra-cellular crude ethyl acetate extracts Talaromyces tratensis SS10. In study, qualitative quantitative phytochemical studies various solvent T. have been carried out using standard protocols. Later, extract was analyzed phytochemicals Gas Chromatography Mass Spectrometry (GC-MS). Further, properties done by Ferric reducing power assay (FRAP). this has MTT against human cancer cells such as MDA MB 231, HeLa, HT-29. Ethyl exhibited a higher yield chemical extraction than other solvents used. GCMS analysis revealed major phytoconstituents N-(1,1-Dimethylpropyl)-2,2,3-trimethylaziridine-1-carboxamide, 1-Undecanol, 5,5 Dimethyl-3-vinyl cyclohex-2-en-1-one, 1,2-Benzenedicarboxylic acid, bis (2-methyl propyl) ester. showed highest percentage Fe3+ reduction (48.093±1.469%) at 120 μg/mL, with an IC50 value 157.26 μg/mL concentration. Furthermore, 100 significant cell death rates cytotoxic assays, indicating low viable all three examined lines. shown dose-dependent effect tested better (6.25 μg/mL) recorded case HeLa lines followed 12.5 both 231 HT-29 presence bioactive compounds Benzeneethanamine, N-[(pentafluorophenyl)methylene]-beta.,3,4-tris[(trimethylsilyl) oxy]-, bis(2-methylpropyl) ester, cyclononasiloxane, octadecamethyl- may contributed extracts’ strong properties. current study’s findings show that SS10 drug development due its constituents, which possess biological activities.

Language: Английский

Citations

0