European bilberry extract reduces high-temperature baked food-induced accumulation of Nε-carboxymethyllysine and Nε-carboxyethyllysine in vivo DOI
Xiaoxing Mo,

Lihui Shen,

Xinyu Wang

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115157 - 115157

Published: Oct. 2, 2024

Language: Английский

Burdens and trends of age-related macular degeneration at global, regional, and national levels,1990–2021: findings from the 2021 global burden of disease study DOI
Yongsheng Zhou,

Wenchang Jia,

Jianling Song

et al.

Eye, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
Dissecting the Biological Complexity of Age-Related Macular Degeneration: Is it One Disease, Multiple Separate Diseases, or a Spectrum? DOI Creative Commons
Jason Miller, Benjamin Thompson, James T. Handa

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: 254, P. 110304 - 110304

Published: Feb. 19, 2025

Language: Английский

Citations

0
Features That Distinguish Age-Related Macular Degeneration from Aging DOI
Dorota Skowronska‐Krawczyk, Silvia C. Finnemann, Maria B. Grant

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: 254, P. 110303 - 110303

Published: Feb. 20, 2025

Language: Английский

Citations

0
Advanced Glycation End Products in Disease Development and Potential Interventions DOI Creative Commons
Yihan Zhang, Zhen Zhang,

Chuyue Tu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 492 - 492

Published: April 18, 2025

Advanced glycation end products (AGEs) are a group of compounds formed through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs can be generated in the body introduced dietary sources smoking. Recent clinical animal studies have highlighted significant role various health conditions. These accumulate nearly all mammalian tissues associated with range diseases, including diabetes its complications, cardiovascular disease, neurodegeneration. This review summarizes major diseases linked to AGE accumulation, presenting both experimental evidence. The pathologies induced by share common mechanisms across different organs, primarily involving oxidative stress, chronic inflammation, direct protein cross-linking. Interventions targeting AGE-related focus on inhibiting formation using synthetic natural antioxidants, as well intake lifestyle modifications. recognized risk factors that impact accelerate aging, particularly individuals hyperglycemia. Monitoring level implementing nutritional interventions help maintain overall reduce complications.

Language: Английский

Citations

0
Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study DOI Creative Commons
Ssu-Yu Pan, Chien‐Hsiang Weng,

Shang-Feng Tsai

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(4), P. 58 - 58

Published: April 21, 2025

To compare the impact of sodium-glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase 4 (DPP-4) inhibitors on age-related macular degeneration (AMD) risk among patients with type diabetes mellitus (T2DM). This multinational, retrospective cohort study used electronic medical records from healthcare institutions across 21 countries. Adults 50 years or older T2DM who had a prior prescription metformin initiated SGLT2 DPP-4 2013 to 2023 were included. The inhibitor groups propensity score matched in 1:1 ratio balance baseline characteristics followed for up 5 observe occurrence AMD. Statistical analysis was performed using Cox proportional hazards model Kaplan-Meier analysis. Our final included 20,966 prescribed inhibitors. Compared group, group associated significantly lower risks AMD (hazard [HR], 0.71; 95% confidence interval [CI], 0.58-0.85) dry (HR, 0.61; CI, 0.46-0.80) but not wet 0.74; 0.48-1.16). compared linked reduced White population, empagliflozin dapagliflozin, individuals glycated hemoglobin < 8.5%, estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2, hypertension, dyslipidemia, regardless body mass index level. In T2DM, those may experience

Language: Английский

Citations

0
European bilberry extract reduces high-temperature baked food-induced accumulation of Nε-carboxymethyllysine and Nε-carboxyethyllysine in vivo DOI
Xiaoxing Mo,

Lihui Shen,

Xinyu Wang

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 197, P. 115157 - 115157

Published: Oct. 2, 2024

Language: Английский

Citations

0