Emerging Therapeutic Strategies to Overcome Drug Resistance in Cancer Cells

Cancers, Journal Year: 2024, Volume and Issue: 16(13), P. 2478 - 2478

Published: July 7, 2024

The rise of drug resistance in cancer cells presents a formidable challenge modern oncology, necessitating the exploration innovative therapeutic strategies. This review investigates latest advancements overcoming mechanisms employed by cells, focusing on emerging modalities. intricate molecular insights into resistance, including genetic mutations, efflux pumps, altered signaling pathways, and microenvironmental influences, are discussed. Furthermore, promising avenues offered targeted therapies, combination treatments, immunotherapies, precision medicine approaches highlighted. Specifically, synergistic effects combining traditional cytotoxic agents with molecularly inhibitors to circumvent pathways examined. Additionally, evolving landscape immunotherapeutic interventions, immune checkpoint adoptive cell is explored terms bolstering anti-tumor responses evasion mechanisms. Moreover, significance biomarker-driven strategies for predicting monitoring treatment underscored, thereby optimizing outcomes. For future direction paradigms, current focused prevailing challenges improving patient outcomes, through an integrative analysis these

Language: Английский

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Cancer nanomedicine: Smart arsenal in the war against cancer

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114030 - 114030

Published: Feb. 1, 2025

Language: Английский

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The role of Ursolic acid, a pharmacologically active compound from Ocimum sanctum L. as a potential chemotherapeutic agent

Current Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: 21(2), P. 77 - 87

Published: Feb. 1, 2025

Language: Английский

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Synthesis of Carbon Dots from Spent Coffee Grounds: Transforming Waste into Potential Biomedical Tools

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Carbon dots were synthesised from spent coffee grounds via a novel acetone precipitation approach, featuring superior physico-chemical properties for potential biomedical applications. Created in BioRender. Zhou, Y. (2025) https://BioRender.com/m82x982.

Language: Английский

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Revenge Unraveling the Fortress: Exploring Anticancer Drug Resistance Mechanisms in BC for Enhanced Therapeutic Strategies

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104707 - 104707

Published: March 1, 2025

Language: Английский

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The Cytotoxic Effect of Cobalt Oxide Nanoparticle Conjugated by Menthol on Colorectal Cancer Cell Line and Evaluation of the Expression of CASP8 and FEZF1-AS1

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 2, 2025

Language: Английский

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A review on the molecular mechanisms and pharmacology of andrographolide from Andrographis paniculata (Burm.f.) Nees in the management of the interplay between type 2 diabetes and breast cancer.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100772 - 100772

Published: Feb. 1, 2025

Language: Английский

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Antiproliferative activity of prepared Aloe vera leaf skin extract-loaded essential oil nanoemulsions using Box-Behnken design

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 228, P. 120928 - 120928

Published: March 29, 2025

Language: Английский

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Capecitabine loaded potato starch-chitosan nanoparticles: A novel approach for targeted therapy and improved outcomes in aggressive colon cancer

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 200, P. 114328 - 114328

Published: May 17, 2024

Language: Английский

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"Unlocking Therapeutic Precision: “Camptotheca acuminata, a Traditional Chinese Herb Tailored for Phytonano-Cancer Theranostics”

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 11, P. 100447 - 100447

Published: May 21, 2024

In recent years, there has been a growing interest in leveraging traditional medicinal plants for modern therapeutic approaches, particularly cancer treatment. The review explores the potential of Camptotheca acuminata, Chinese plant, treatment through innovative phytonano-based drug delivery systems. acuminata contains camptothecin, potent anticancer compound, but its use is hindered by poor solubility, bioavailability, and systemic toxicity. study highlights how phytonano-technology can enhance accuracy reduce side effects using nanoparticles to encapsulate selectively deliver drugs directly cells. This approach could significantly improve oncology therapy addressing limitations chemotherapy. Using PubMed Scopus, prospective research on activities several mushroom species during past 20 years were searched. query included "Camptotheca acuminata," "cancer," "nanoparticles," "traditional medicine," "theranostics." Only entire English-language articles used. Phytonano-Cancer Theranostics with camptothecin effectively targets cells, showing substantial uptake vitro prolonged circulation accumulation at tumor sites vivo. These results demonstrate precise effective therapy. integration offers promising targeted theranostic capabilities However, challenges remain, including optimizing nanoparticle design stability, scalability, biocompatibility, overcoming biological barriers efficient targeting. Addressing these requires interdisciplinary maximize strategies patient outcomes.

Language: Английский

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