In-Vitro evaluation of antidiabetic, antioxidant, and anti-inflammatory activities in Mucuna pruriens seed extract DOI Creative Commons
Jagat Pal Yadav, Prateek Pathak,

Seema Yadav

et al.

Clinical Phytoscience, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 14, 2024

Abstract Background Mucuna pruriens var. utilis (Wall. ex Wight) belonging to the family Fabaceae. Renowned for its diverse array of phytochemicals, this plant has been historically employed in treatment various ailments. The objectives study are evaluate anti-diabetic, anti-inflammatory, and antioxidant properties optimized M. seed extract. Methods in-vitro anti-inflammatory activity ethanolic extracts was scrutinized using Human Red Blood Cell (HRBC) method. To activity, ABTS DPPH assays were employed. Furthermore, antidiabetic assessed through α-amylase α-glucosidase inhibition assays. Results In extract numerous phytoconstituents found by doing a phytochemical analysis (alkaloids, flavonoids, phenols, saponins, steroids, glycosides, tannins). total phenolic flavonoid content determined be 112.07 ± 1.21 mg gallic acid equivalents GAE/g 101.41 1.08 quercetin QE/g respectively. investigation exhibited high activities dose-dependent manner. shows that 32.26 3.23%, potent effect radical scavenging assay IC 50 67.46 1.45 µg/mL 63.34 2.27 addition, showed promising potential inhibiting 33.42 1.35 28.34 1.41 µg/mL. Conclusion These findings provide additional support traditional medicinal use treating inflammation, oxidative stress, diabetes mellitus.

Language: Английский

Phytoconstituents as modulators of NF-κB signalling: Investigating therapeutic potential for diabetic wound healing DOI Creative Commons
Jagat Pal Yadav, Amita Verma,

Prateek Pathak

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117058 - 117058

Published: July 4, 2024

The NF-κB pathway plays a pivotal role in impeding the diabetic wound healing process, contributing to prolonged inflammation, diminished angiogenesis, and reduced proliferation. In contrast modern synthetic therapies, naturally occurring phytoconstituents are well-studied inhibitors of that now attracting increased attention context because lower toxicity, better safety efficacy, cost-effectiveness. This study explores recent research on phytoconstituent-based therapies delve into their action mechanisms targeting potential for assisting effective wounds. For this purpose, we have carried out surveys literature analyzed studies from prominent databases such as Science Direct, Scopus, PubMed, Google Scholar, EMBASE, Web Science. classification various categorie as: alkaloids, triterpenoids, phenolics, polyphenols, flavonoids, monoterpene glycosides, naphthoquinones tocopherols. Noteworthy phytoconstituents, including Neferine, Plumbagin, Boswellic acid, Genistein, Luteolin, Kirenol, Rutin, Vicenin-2, Gamma-tocopherol, Icariin, Resveratrol, Mangiferin, Betulinic Berberine, Syringic Gallocatechin, Curcumin, Loureirin-A, Loureirin-B, Lupeol, Paeoniflorin, Puerarin emerge these promising agents through inhibition pathway. Extensive has revealed how they modulate signalling pathways, NF-κB, demonstrate development therapeutic assist chronic

Language: Английский

Citations

21
Preparation, characterization and in vitro evaluation of anticancer and antioxidant effects of luteolin-loaded nanocapsules DOI Creative Commons
Giuseppe Granata,

Paolo Accardo,

Claudia Giovanna Leotta

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106754 - 106754

Published: Feb. 1, 2025

Language: Английский

Citations

0
Integrating synthesis, enzyme inhibition and in silico studies: Carbamoyl luteolin derivatives targeting Alzheimer's disease DOI
The‐Huan Tran, Nguyen Thi Ai Nhung, Thi‐Cam‐Nhung Cao

et al.

Journal of the Chinese Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Alzheimer's disease is one of the most common neurodegenerative disorders, where acetylcholinesterase (AChE) and monoacylglycerol lipase (MAGL) play critical roles in its pathophysiology. In this study, six carbamoyl luteolin derivatives were synthesized from via reactions with chloride reagents, achieving yields ranging 41% to 64%. The structures these characterized using UV, HRMS, 1 H‐NMR, 13 C‐NMR spectroscopy. Biological evaluation demonstrated that L1 (IC 50 = 42.0 μM for AChE, 58.0 MAGL) L3 114.2 34.9 exhibited significantly enhanced inhibitory activities compared luteolin. Computational studies, including molecular docking dynamics simulations, validated strong binding affinities stable interactions enzymes' active sites. These findings suggest modifying carbamate groups can improve enzymatic activity, providing a foundation developing flavone‐based as potential therapeutic candidates disease.

Language: Английский

Citations

0
Harnessing Potential of Liposomal Drug Carriers for Enhanced Pharmacokinetic Profile of Flavonoids DOI
Nazir Hussain, S. K. Dubey,

C.K. Katiyar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106978 - 106978

Published: April 1, 2025

Language: Английский

Citations

0
Chemical constituents, health-promoting effects, potential risks and future prospective of Chinese herbal tea: A review DOI Creative Commons

Xingmei Lin,

Huiping Li,

Baokang Huang

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 121, P. 106438 - 106438

Published: Sept. 3, 2024

Language: Английский

Citations

3
Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics DOI Creative Commons
Md. Ataur Rahman, Mushfiq Hassan Shaikh, Rajat Das Gupta

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2645 - 2645

Published: Nov. 19, 2024

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, thereby cell survival. Oral health essential component of integrated well-being, it critical for developing therapeutic interventions to understand the molecular mechanisms underlying maintenance oral homeostasis. However, because complex dynamic relationship between autophagy health, associated treatment modalities have not yet been well elucidated. Determining how affects at level may enhance understanding prevention targeted diseases. At level, hard soft tissues develop interactions epithelial mesenchymal cells. Aging contributes progression various disorders including periodontitis, cancer, periapical lesions during aging. levels decrease with age, thus indicating a possible association In this review, we critically review aspects their significance in context diseases lesions, periodontal conditions, candidiasis. A better its can guide us new preventative strategies management

Language: Английский

Citations

2
In-Vitro evaluation of antidiabetic, antioxidant, and anti-inflammatory activities in Mucuna pruriens seed extract DOI Creative Commons
Jagat Pal Yadav, Prateek Pathak,

Seema Yadav

et al.

Clinical Phytoscience, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 14, 2024

Abstract Background Mucuna pruriens var. utilis (Wall. ex Wight) belonging to the family Fabaceae. Renowned for its diverse array of phytochemicals, this plant has been historically employed in treatment various ailments. The objectives study are evaluate anti-diabetic, anti-inflammatory, and antioxidant properties optimized M. seed extract. Methods in-vitro anti-inflammatory activity ethanolic extracts was scrutinized using Human Red Blood Cell (HRBC) method. To activity, ABTS DPPH assays were employed. Furthermore, antidiabetic assessed through α-amylase α-glucosidase inhibition assays. Results In extract numerous phytoconstituents found by doing a phytochemical analysis (alkaloids, flavonoids, phenols, saponins, steroids, glycosides, tannins). total phenolic flavonoid content determined be 112.07 ± 1.21 mg gallic acid equivalents GAE/g 101.41 1.08 quercetin QE/g respectively. investigation exhibited high activities dose-dependent manner. shows that 32.26 3.23%, potent effect radical scavenging assay IC 50 67.46 1.45 µg/mL 63.34 2.27 addition, showed promising potential inhibiting 33.42 1.35 28.34 1.41 µg/mL. Conclusion These findings provide additional support traditional medicinal use treating inflammation, oxidative stress, diabetes mellitus.

Language: Английский

Citations

0