TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 183, P. 118104 - 118104
Published: Dec. 12, 2024
Language: Английский
Alexandria Engineering Journal, Journal Year: 2024, Volume and Issue: 87, P. 515 - 523
Published: Jan. 1, 2024
Significant ethical and health concerns have been brought up recently by the illegitimate use of highly strong synthetic opioids, including fentanyl, as doping agents in sports. Therefore, requirement for quick accurate detection techniques to spot illicit drugs athletes has never more important. Our study presents a novel biosensor sensitive fentanyl based on nanocomposite polyaniline (PANI) glassy carbon electrode modified with g-C3N4, which is first its kind. The g-C3N4-PANI nanocomposite's successful synthesis was confirmed structural investigations performed using SEM, XRD, FT-IR. Studies electrochemical effects g-C3N4 PANI cyclic voltammetry (CV) amperometry revealed that hybrid composite enhanced sensitivity, selectivity, stability, accuracy measurement. With sensitivity 0.45445 μA/μM, measurements broad consistent linear range spanning from 10 920 μM. threshold established at 0.006 Additionally, performance assessed several real-samples made athlete pee. findings displayed satisfactory recovery values ranging 90.00% 98.00% low relative standard deviation (less than 4.74%) demonstrated g-C3N4/PANI nanocomposite-based potential be an effective anti-doping control tool, opening door practical maintaining fairness safety competitive analysis showed combination resulted material properties, contributed high biosensor.
Language: Английский
Citations
5
Frontiers in Drug Delivery, Journal Year: 2024, Volume and Issue: 4
Published: Feb. 1, 2024
Ovarian cancers are a complex and heterogenic group of malignancies that difficult to detect, diagnose treat. Fortunately, considerable knowledge ovarian cancer specific biomarkers has been generated, is pertinent the development novel theranostic platforms by combining therapies diagnostics. Genomic proteomic data invaluable in providing critical biomolecular targets for approaches. Exploitation wealth biomarker research conducted offers viable as beacons detection, diagnosis, therapeutic targeting. These markers can be used theranostics, treatment strategy combines therapy diagnostics common nuclear medicine, where radionuclides both diagnosis treatment. The theranostics taken substantial focus recent years battle against cancer. Yet date only one technology emerged clinical practice. However, given field poised see emergence revolutionary disease monitoring outcomes through their incorporation into strategies. future set enable precise targeted treatment, vigilant monitoring. This review aims assess status diagnostic tools practice, development, or pre-clinical highlighting newly emerging applications.
Language: Английский
Citations
5
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118119 - 118119
Published: Dec. 1, 2024
Language: Английский
Citations
5
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: March 16, 2024
Lung cancer remains the leading cause of mortality worldwide. Small cell lung (SCLC) accounts for 10-15% cases and has an overall 5-years survival rate only 15%. Neuron-specific enolase (NSE) been identified as a useful biomarker early SCLC diagnosis therapeutic monitoring. This work reports electrochemical immunosensing platform based on graphene-graphitic carbon nitride (g-C3N4) nanocomposite ultrasensitive NSE detection. The g-C3N4 nanosheets graphene were synthesized via liquid exfoliation integrated through self-assembly to form nanocomposite. was used modify screen-printed electrodes followed by covalent immobilization anti-NSE antibodies. unique properties graphene-g-C3N4 composite facilitated efficient antibody loading while also enhancing electron transfer efficiency response. Systematic optimization experimental parameters performed. immunosensor exhibited wide linear detection range 10 pg/mL 100 ng/mL low limit 3 along with excellent selectivity against interferences. Real serum matrix analysis validated applicability developed sensitive accurate quantifica-tion at clinically relevant levels. novel electro-chemical immunoassay demonstrates great promise SCLC.
Language: Английский
Citations
4
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 183, P. 118104 - 118104
Published: Dec. 12, 2024
Language: Английский
Citations
4