Evodiamine and its nano‐based approaches for enhanced cancer therapy: recent advances and challenges
Journal of the Science of Food and Agriculture,
Journal Year:
2024,
Volume and Issue:
104(14), P. 8430 - 8444
Published: May 31, 2024
Evodiamine
is
a
bioactive
alkaloid
extracted
from
the
Evodia
rutaecarpa
plant.
It
has
various
pharmacological
effects
including
anti-cancer,
anti-bacterial,
anti-obesity,
anti-neurodegenerative,
anti-depressant,
and
cardiac
protective
properties.
demonstrates
potent
anti-cancer
activity
by
inhibiting
proliferation
of
cancer
cells
in
vitro
vivo.
Despite
health-promoting
properties
evodiamine,
its
clinical
use
hindered
low
water
solubility,
poor
bioavailability,
toxicity.
Thus,
there
need
to
develop
alternative
drug
delivery
systems
for
evodiamine
enhance
permeability,
stability,
as
well
facilitate
targeted,
prolonged,
controlled
release.
Nanocarriers
can
increase
therapeutic
potential
therapy
while
reducing
adverse
side
effects.
To
date,
numerous
attempts
have
been
made
through
development
smart
nanocarriers
overcome
drawbacks
evodiamine.
This
review
focuses
on
applications,
mechanisms,
limitations
Various
nanocarriers,
lipid-based
nanoparticles,
polymeric
cyclodextrins,
so
forth,
discussed
extensively
delivery.
Nano-drug
could
efficacy
aims
present
comprehensive
critical
evaluation
several
nano-formulations
therapy.
©
2024
Society
Chemical
Industry.
Language: Английский
Development and characterization of nano-hydroxyapatite/gelatin/PVA/alginate-based multifunctional active scaffolds for bone regeneration: An in vitro and in vivo study
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 141160 - 141160
Published: Feb. 1, 2025
Language: Английский