Laccase-based biocatalytic systems application in sustainable degradation of pharmaceutically active contaminants DOI Creative Commons

Anil Kumar Singh,

Pedro Abellanas-Pérez, Diandra de Andrades

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136803 - 136803

Published: Dec. 7, 2024

The outflow of pharmaceutically active chemicals (PhACs) exerts a negative impact on biological systems even at extremely low concentrations. For instance, enormous threats to human and aquatic species have resulted from the widespread use antibiotics in ecosystems, which stimulate emergence formation antibiotic-resistant bacterial associated genes. Additionally, it is challenging eliminate these PhACs by employing conventional physicochemical water treatment techniques. Enzymatic approaches, including laccase, been identified as promising alternative broad array matrices. However, their application environmental bioremediation hindered several factors, enzyme's stability its location aqueous environment. Such obstacles may be surmounted laccase immobilization, enables enhanced (including inactivation caused substrate), thus improved catalysis. This review emphasizes potential hazards organisms within detection concentration range ngL-1 µgL-1, well deployment laccase-based multifunctional biocatalytic for environmentally friendly mitigation anticancer drugs, analgesics/NSAIDs, antibiotics, antiepileptic agents, beta blockers micropollutants. approach could reduce underlying toxicological consequences. In addition, current developments, applications, viewpoints focused computer-assisted investigations laccase-PhACs binding enzyme cavities degradability prediction.

Language: Английский

Laccase-based biocatalytic systems application in sustainable degradation of pharmaceutically active contaminants DOI Creative Commons

Anil Kumar Singh,

Pedro Abellanas-Pérez, Diandra de Andrades

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136803 - 136803

Published: Dec. 7, 2024

The outflow of pharmaceutically active chemicals (PhACs) exerts a negative impact on biological systems even at extremely low concentrations. For instance, enormous threats to human and aquatic species have resulted from the widespread use antibiotics in ecosystems, which stimulate emergence formation antibiotic-resistant bacterial associated genes. Additionally, it is challenging eliminate these PhACs by employing conventional physicochemical water treatment techniques. Enzymatic approaches, including laccase, been identified as promising alternative broad array matrices. However, their application environmental bioremediation hindered several factors, enzyme's stability its location aqueous environment. Such obstacles may be surmounted laccase immobilization, enables enhanced (including inactivation caused substrate), thus improved catalysis. This review emphasizes potential hazards organisms within detection concentration range ngL-1 µgL-1, well deployment laccase-based multifunctional biocatalytic for environmentally friendly mitigation anticancer drugs, analgesics/NSAIDs, antibiotics, antiepileptic agents, beta blockers micropollutants. approach could reduce underlying toxicological consequences. In addition, current developments, applications, viewpoints focused computer-assisted investigations laccase-PhACs binding enzyme cavities degradability prediction.

Language: Английский

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