Medicina,
Journal Year:
2024,
Volume and Issue:
60(11), P. 1871 - 1871
Published: Nov. 14, 2024
This
study
aims
to
investigate
whether
Signal
Transducer
and
Activator
of
Transcription
4
(STAT4)
influences
the
anti-tumor
immune
response
is
possibly
involved
in
initiation
or
relapse
pituitary
adenomas
(PAs)
by
examining
Cancer Cell International,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Nov. 5, 2023
Abstract
Gamma-butyrobetaine
hydroxylase
1
antisense
RNA
(BBOX1-AS1),
located
on
human
chromosome
11
p14,
emerges
as
a
critical
player
in
tumorigenesis
with
diverse
oncogenic
effects.
Aberrant
expression
of
BBOX1-AS1
intricately
regulates
various
cellular
processes,
including
cell
growth,
epithelial–mesenchymal
transition,
migration,
invasion,
metastasis,
death,
and
stemness.
Notably,
the
was
significantly
correlated
clinical-pathological
characteristics
tumor
prognoses,
it
could
also
be
used
for
diagnosis
lung
esophageal
cancers.
Through
its
involvement
ceRNA
network,
competitively
binds
to
eight
miRNAs
ten
different
cancer
types.
Additionally,
can
directly
modulate
downstream
protein-coding
genes
or
act
an
mRNA
stabilizer.
The
implications
extend
signaling
pathways,
Hedgehog,
Wnt/β-catenin,
MELK/FAK
pathways.
Moreover,
influences
drug
resistance
hepatocellular
carcinoma.
present
study
provides
systematic
review
clinical
significance
BBOX1-AS1’s
aberrant
It
sheds
light
intricate
molecular
mechanisms
through
which
initiation
progression
outlines
potential
avenues
future
research
this
field.
Medicina,
Journal Year:
2024,
Volume and Issue:
60(11), P. 1871 - 1871
Published: Nov. 14, 2024
This
study
aims
to
investigate
whether
Signal
Transducer
and
Activator
of
Transcription
4
(STAT4)
influences
the
anti-tumor
immune
response
is
possibly
involved
in
initiation
or
relapse
pituitary
adenomas
(PAs)
by
examining