Identification of transcription factors associated with the disease-free survival of triple-negative breast cancer through weighted gene co-expression network analysis DOI Open Access
H T Wang, Hao Ran, Wei Liu

et al.

CytoJournal, Journal Year: 2024, Volume and Issue: 21, P. 71 - 71

Published: Dec. 23, 2024

Triple-negative breast cancer (TNBC) is a subtype of that has worse prognosis than the other subtypes because its high recurrence and metastasis rates. The objective this study to identify regulatory factors are associated with disease-free survival (DFS) TNBC potential biomarkers for treatment. We obtained GSE97342 dataset from Gene Expression Omnibus website conducted weighted gene co-expression network analysis (WGCNA) modules DFS TNBC. Subsequently, biological functions were elucidated through Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses. Cross-checking Human Transcription Factor Database facilitated selection hub transcription univariate Cox regression overlapping factors. Utilizing bioinformatics analysis, we assessed prognostic significance these factors, investigated their target genes, explored associations tumor immune cells in Finally, expression levels validated by immunohistochemical staining, quantitative reverse polymerase chain reaction (qRT-PCR), Western blotting. Through WGCNA identified three correlated GO KEGG analyses genes within modules. Survival pinpointed factors: Forkhead box D1 (FOXD1), aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), zinc finger protein 132 (ZNF132). level FOXD1 was negatively prognoses patients TNBC, whereas two positively Immunohistochemical qRT-PCR, blotting discovered (FOXD1, ARNT2, ZNF132) These correlations suggested as predictors

Language: Английский

Conferone: a comprehensive review of sources, extraction, characterization, biological and medicinal activities DOI
Mohammad Beiranvand, Gholamreza Dehghan

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

2
Ferula sesquiterpenes, ferutinin, galbanic acid and karatavic acid, suppress thymocyte volume regulation and proliferation by blocking the volume-sensitive anion channel DOI Open Access
Ravshan Z. Sabirov, S. I. Rustamova, Gulnoza A. Toshtemirova

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117875 - 117875

Published: Feb. 5, 2025

Language: Английский

Citations

1
A novel approach to glioblastoma multiforme treatment using modulation of key pathways by naturally occurring small molecules DOI
Amir R. Afshari, Mehdi Sanati, Samaneh Aminyavari

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Language: Английский

Citations

0
Sesquiterpenes and prostate cancer DOI Creative Commons
Kübra Uzun, Cenk Yücel Bilen, Funda Nuray Yalçın

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

0
Galbanic acid delays the development of seizures by modulating the expression of TNFα, IL1β, and TLR4 genes and reducing hippocampal nitrite levels and may be useful in the treatment of epilepsy DOI
Najmeh Asgharzadeh,

Saeid Ghavamnia,

Hossein Amini‐Khoei

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138200 - 138200

Published: March 1, 2025

Language: Английский

Citations

0
Harnessing the metastatic potential of human osteosarcoma cells by natural coumarin galbanic acid DOI
Abdolreza Ahmadi,

Fatemehsadat Hosseini,

Zahra Nasiri Sarvi

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

Citations

0
Galbanic acid suppresses melanoma cell migration and invasion by reducing MMP activity and downregulating N-cadherin and fibronectin DOI

Masoumeh Azad,

Fatemehsadat Hosseini,

Halimeh Hassanzade

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(8), P. 5779 - 5788

Published: Feb. 7, 2024

Language: Английский

Citations

3
The potential therapeutic effect of melatonin in oxaliplatin combination therapy against chemoresistant colorectal cancer cells DOI

Masoumeh Dehghanzad,

Mohammad Mohammadi,

Mohaddeseh Nejati

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Feb. 24, 2024

Language: Английский

Citations

2
Investigating the Effect of Galbanic Acid on Lipin-1 and Lipin-2 Genes in Fatty Liver Cells with Palmitate DOI Creative Commons
Hadis Musavi,

Reza Iraie,

Maryam Mohammadi

et al.

Advanced Biomedical Research, Journal Year: 2024, Volume and Issue: 13(1)

Published: Nov. 1, 2024

Background: Non-alcoholic fatty liver disease is related to lipid accumulation and inflammation. Considering the role of lipin-1 lipin-2 in fat homeostasis inflammation, this study aimed explore effect galbanic acid (Gal) resveratrol (RSV) on alterations gene expression levels protein abundance HepG2 cells lipid-enriched with palmitate (Pal). Materials Methods: were subjected different amounts Gal RSV for 24 hours presence Pal induce accumulation. The RT-PCR method was employed assess genes, while evaluated by western blot analysis. Lipid determined qualitatively semi-quantitatively using oil-red staining technique. Results: treatment increased ( P < 0.05). In contrast, groups treated did not show a substantial variance two genes > Gal/RSV, intensity bands higher compared group 0.01); however, significantly Conclusion: Gal, coumarin compound, Pal. Consequently, research suggests gal as novel strategy regulating cells.

Language: Английский

Citations

1
Identification of transcription factors associated with the disease-free survival of triple-negative breast cancer through weighted gene co-expression network analysis DOI Open Access
H T Wang, Hao Ran, Wei Liu

et al.

CytoJournal, Journal Year: 2024, Volume and Issue: 21, P. 71 - 71

Published: Dec. 23, 2024

Triple-negative breast cancer (TNBC) is a subtype of that has worse prognosis than the other subtypes because its high recurrence and metastasis rates. The objective this study to identify regulatory factors are associated with disease-free survival (DFS) TNBC potential biomarkers for treatment. We obtained GSE97342 dataset from Gene Expression Omnibus website conducted weighted gene co-expression network analysis (WGCNA) modules DFS TNBC. Subsequently, biological functions were elucidated through Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses. Cross-checking Human Transcription Factor Database facilitated selection hub transcription univariate Cox regression overlapping factors. Utilizing bioinformatics analysis, we assessed prognostic significance these factors, investigated their target genes, explored associations tumor immune cells in Finally, expression levels validated by immunohistochemical staining, quantitative reverse polymerase chain reaction (qRT-PCR), Western blotting. Through WGCNA identified three correlated GO KEGG analyses genes within modules. Survival pinpointed factors: Forkhead box D1 (FOXD1), aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), zinc finger protein 132 (ZNF132). level FOXD1 was negatively prognoses patients TNBC, whereas two positively Immunohistochemical qRT-PCR, blotting discovered (FOXD1, ARNT2, ZNF132) These correlations suggested as predictors

Language: Английский

Citations

0