Revolutionizing colorectal cancer treatment: unleashing the potential of miRNAs in targeting cancer stem cells

Future Oncology, Journal Year: 2023, Volume and Issue: 19(35), P. 2369 - 2382

Published: Nov. 1, 2023

Colorectal cancer (CRC) is a significant contributor to mortality worldwide, and the presence of stem cells (CSC) represents major challenge for achieving effective treatment. miRNAs have emerged as critical regulators gene expression, recent studies highlighted their role in regulating stemness therapeutic resistance CRC cells. This review highlights mechanisms CSC development, therapy potential targets CRC. It emphasizes promise novel approach treatment calls further research explore miRNA-based therapies strategies delivering CSCs vivo.

Language: Английский

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Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review

Epigenetics Insights, Journal Year: 2023, Volume and Issue: 16

Published: Jan. 1, 2023

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS that affects millions people worldwide. The causes disease remain unknown despite extensive efforts to understand it. CircRNAs are unique class endogenous non-coding RNA abundant, stable, conserved, and specifically expressed molecules, making them promising biomarker diseases. This review investigates role circRNA in MS pathogenicity their potential as through comprehensive literature search conducted 8 scientific databases. studies found there differentially circRNAs patients compared healthy controls (HC), this difference even more pronounced different subtypes. Enrichment linkage disequilibrium (LD) blocks harbor MS-associated SNPs suggests these manipulate levels surrounding area, contributing pathogenicity. While shows promise an indicator or for pathology, further research needed fully explore its impact on human biology.

Language: Английский

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Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 16, 2024

Abstract Background Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications pancreatic cancer development remains poorly understood. Methods results In this study, we performed a global characterization of protein targets PDAC cells through iodoTMT-based quantitative proteomics, which identified over 4300 oxidized sites more than 2100 proteins HPDE6c7 PANC-1 cells. Among them, 1715 residues were shown to be differentially between Also, charged amino acids including aspartate, glutamate lysine significantly overrepresented flanking sequences cysteines. Differentially enriched multiple cancer-related processes signaling pathways. Specifically, the HIF-1 exhibited significant alterations cells, reduced PHD2 human tissues was correlated with lower survival time patients. Conclusion These investigations provided new insights into oxidation-regulated during pathogenesis, might further explored for diagnosis treatment.

Language: Английский

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Circ_0002722-induced regulation of YAP promotes platinum resistance in oral squamous cell carcinoma: Implications for verteporfin therapy

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 229, P. 116460 - 116460

Published: Aug. 3, 2024

Language: Английский

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Role of circRNAs in regulating cell death in cancer: a comprehensive review

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 7, 2024

Language: Английский

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