Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 14, 2024

Liver fibrosis is a disease with great global health and economic burden. Existing data highlights itraconazole (ITRCZ) as potentially effective anti-fibrotic therapy. However, ITRCZ effect hindered by several limitations, such poor solubility bioavailability. This study aimed to formulate optimize chitosan nanoparticles (Cht NPs) loaded new strategy for managing liver fibrosis. ITRCZ-Cht NPs were optimized utilizing developed 2

Language: Английский

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Potential neuroprotective and autophagy-enhancing effects of alogliptin on lithium/pilocarpine-induced seizures in rats: Targeting the AMPK/SIRT1/Nrf2 axis

Life Sciences, Journal Year: 2024, Volume and Issue: 352, P. 122917 - 122917

Published: July 15, 2024

Language: Английский

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Alogliptin attenuates STZ-induced diabetic nephropathy in rats through the modulation of autophagy, apoptosis, and inflammation pathways: Targeting NF-κB and AMPK/mTOR pathway

Life Sciences, Journal Year: 2024, Volume and Issue: 361, P. 123307 - 123307

Published: Dec. 10, 2024

Language: Английский

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Alogliptin attenuates testicular damage induced by monosodium glutamate in both juvenile and adult male rats by activating autophagy: ROS Dependent AMPK/mTOR

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: unknown, P. 108826 - 108826

Published: Dec. 1, 2024

Language: Английский

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