The emerging role of non-coding RNAs in the Wnt/β-catenin signaling pathway in Prostate Cancer DOI
Imran Kazmi, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 254, P. 155134 - 155134

Published: Jan. 14, 2024

Language: Английский

Pollutants to pathogens: The role of heavy metals in modulating TGF-β signaling and lung cancer risk DOI
Asif Ahmad Bhat, Ehssan Moglad, Pooja Bansal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155260 - 155260

Published: March 11, 2024

Language: Английский

Citations

8
Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration DOI
Riya Thapa, Asif Ahmad Bhat, Moyad Shahwan

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

Citations

8
PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities DOI
Mohammed Ageeli Hakami, Ali Hazazi, Farhan R. Khan

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 155019 - 155019

Published: Dec. 7, 2023

Language: Английский

Citations

20
Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis DOI
Asif Ahmad Bhat, Yassine Riadi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155224 - 155224

Published: Feb. 23, 2024

Language: Английский

Citations

6
Nrf2 pathways in neuroprotection: Alleviating mitochondrial dysfunction and cognitive impairment in aging DOI
Asif Ahmad Bhat, Ehssan Moglad, Ahsas Goyal

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123056 - 123056

Published: Sept. 12, 2024

Language: Английский

Citations

6
Therapeutic approaches targeting aging and cellular senescence in Huntington's disease DOI Creative Commons
Asif Ahmad Bhat, Ehssan Moglad, Muhammad Afzal

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Huntington's disease (HD) is a devastating neurodegenerative that manifested by gradual loss of physical, cognitive, and mental abilities. As the advances, age has major impact on pathogenic signature mutant huntingtin (mHTT) protein aggregation. This review aims to explore intricate relationship between aging, mHTT toxicity, cellular senescence in HD. Scientific data interplay mHTT, HD were collected from several academic databases, including PubMed, Google Scholar, Google, ScienceDirect. The search terms employed "AGING," "HUNTINGTON'S DISEASE," "MUTANT HUNTINGTIN," "CELLULAR SENESCENCE." Additionally, gather information molecular mechanisms potential therapeutic targets, was extended include relevant such as "DNA DAMAGE," "OXIDATIVE STRESS," "AUTOPHAGY." According research, aging leads worsening pathophysiology through some processes. result accumulation, promoted, which causes DNA damage, oxidative stress, decreased autophagy, increased inflammatory responses. Pro-inflammatory cytokines other substances are released senescent cells, may worsen neuronal damage course disease. It been shown treatments directed at these pathways reduce symptoms enhance longevity experimental animals, pointing new possibility treating condition. Through their amplification harmful effects play crucial roles development Comprehending interplays creates novel opportunities for measures targeted alleviating enhancing patients' quality life.

Language: Английский

Citations

6
Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation DOI
Rajiv Dahiya, Vijaykumar Sutariya, Sheeba Varghese Gupta

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444

Published: Aug. 1, 2024

Language: Английский

Citations

4
Development of a Novel Prognostic Model for Lung Adenocarcinoma Utilizing Pyroptosis‐Associated LncRNAs DOI Creative Commons

Hongyan Bai,

Tiantian Li,

Lina Sun

et al.

Analytical Cellular Pathology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Lung cancer is a highly prevalent and fatal that seriously threatens the safety of people in various regions around world. Difficulty early diagnosis strong drug resistance have always been difficulties treatment lung cancer, so prognosis has focus scientific researchers. This study used genotype-tissue expression (GTEx) genome atlas (TCGA) databases to obtain 477 adenocarcinoma (LUAD) 347 healthy individuals' samples as research subjects divided LUAD patients into low-risk high-risk groups based on prognostic risk scores. Differentially expressed gene (DEG) analysis was performed 25 pyroptosis-related genes obtained from GeneCards MSigDB tissues noncancerous individuals, seven were significantly different among them. Coexpression differential these long noncoding RNAs (lncRNAs) found three lncRNAs (AC012615.1, AC099850.3, AO0001453.2) had significant differences between tissues. We Cox regression least absolute shrinkage sum selection operator (LASSO) construct model for with (pRLs) analyzed value pRLs by Likaplan-Meier curve regression. The results show prediction good ability. In addition, we also studied tumor mutation burden (TMB), immune dysfunction rejection (TIDE), microenvironment scores groups. successfully established pRLs, which provides new insights lncRNA-based strategies.

Language: Английский

Citations

0
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach DOI
Mohd Imran, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Long Intergenic Non-Coding RNAs and BRCA1 in Breast Cancer Pathogenesis: Neighboring Companions or Nemeses? DOI Creative Commons
Olalekan Fadebi, Thabiso Victor Miya,

Richard Khanyile

et al.

Non-Coding RNA, Journal Year: 2025, Volume and Issue: 11(1), P. 9 - 9

Published: Jan. 29, 2025

Breast cancer is one of the leading causes mortality among women, primarily due to its complex molecular landscape and heterogeneous nature. The tendency breast patients develop metastases poses significant challenges in clinical management. Notably, mutations gene 1 (BRCA1) significantly elevate risk. current research endeavors employ diverse approaches, including RNA, DNA, protein studies, explore avenues for early diagnosis treatment cancer. Recent attention has shifted towards long non-coding RNAs (lncRNAs) as promising diagnostic, prognostic, therapeutic targets multifaceted progression Among these, intergenic (lincRNAs), a specific class lncRNAs, play critical roles regulating various aspects tumorigenesis, cell proliferation, apoptosis, epigenetic modulation, tumor invasion, metastasis. Their distinctive expression patterns cellular tissue contexts underscore their importance development progression. Harnessing lincRNAs’ sensitivity precision therapeutic, prognostic markers holds promise management However, potential lincRNAs remains relatively underexplored, particularly context BRCA1-mutated other clinicopathological parameters such receptor status patient survival. Consequently, there an urgent need comprehensive investigations into novel diagnostic biomarkers. This review examines associated with BRCA1 cancer, highlighting future applications.

Language: Английский

Citations

0