In Silico Analysis of Non-Conventional Oxidative Stress-Related Enzymes and Their Potential Relationship with Carcinogenesis DOI Creative Commons
Fábio Rodrigues Ferreira Seiva, Maria Luisa Gonçalves Agneis, Matheus Ribas de Almeida

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1279 - 1279

Published: Oct. 23, 2024

Carcinogenesis is driven by complex molecular events, often involving key enzymes that regulate oxidative stress (OS). While classical such as SOD, catalase, and GPx have been extensively studied, other, non-classical stress-related (OSRE) may play critical roles in cancer progression. We aimed to explore the role of OSRE involved an OS scenario assess their potential contribution carcinogenesis some most prevalent types. Through data mining bioinformatic analysis gene protein expression mutation data, we identified with altered mutations across Functional pathways EGFR, MT-ND, GST, PLCG2, PRDX6, SRC, JAK2 were investigated. Our findings reveal traditionally considered peripheral significant tumor Those contribute initiation progression, well be hallmarks, EMT invasion, proliferation, ROS production. In addition, like SRC found dual both promoting generation being modulated OS. also interact oncogenic signaling pathways, including Wnt/β-catenin JAK2/STAT3, linking them aggressiveness therapeutic resistance. Future research should focus on translating these into clinical applications, development novel inhibitors or drugs targeting enzymes.

Language: Английский

Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases DOI
Azam Hosseinzadeh, Nazila Alinaghian, Mohammad Sheibani

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 344, P. 122557 - 122557

Published: March 11, 2024

Language: Английский

Citations

5
An investigative study on the impact of DLK1 and NCoR1 knockdown by siRNA transfection on endometrial cancer proliferation: unveiling notch interactions DOI

Swathi Chandran Manimegalai,

Sathiya Priya Krishnamoorthy, Vignesh Kalimuthu

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 20, 2025

Language: Английский

Citations

0
Targeting lipid reprogramming in the tumor microenvironment by traditional Chinese medicines as a potential cancer treatment DOI Creative Commons
Qian Zuo, Yingchao Wu,

Yuyu Hu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30807 - e30807

Published: May 1, 2024

In the last ten years, there has been a notable rise in study of metabolic abnormalities cancer cells. However, compared to glucose or glutamine metabolism, less attention paid importance lipid metabolism tumorigenesis. Recent developments lipidomics technologies have allowed for detailed analysis profiles within cells and other cellular players present tumor microenvironment (TME). Traditional Chinese medicine (TCM) its bioactive components long history use treatments are also being studied their potential role regulating reprogramming TME. This review focuses on four core altered by cells: de novo synthesis exogenous uptake fatty acids (FAs), upregulated acid oxidation (FAO), cholesterol accumulation, which offer benefits growth metastasis. The discusses how impacts infiltrating immune cell function phenotype as these interactions between cancer-stromal become more pronounced during progression. Finally, recent literature is highlighted regarding can be metabolically reprogrammed specific herbal with therapeutic related signaling pathways.

Language: Английский

Citations

1
In Silico Analysis of Non-Conventional Oxidative Stress-Related Enzymes and Their Potential Relationship with Carcinogenesis DOI Creative Commons
Fábio Rodrigues Ferreira Seiva, Maria Luisa Gonçalves Agneis, Matheus Ribas de Almeida

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1279 - 1279

Published: Oct. 23, 2024

Carcinogenesis is driven by complex molecular events, often involving key enzymes that regulate oxidative stress (OS). While classical such as SOD, catalase, and GPx have been extensively studied, other, non-classical stress-related (OSRE) may play critical roles in cancer progression. We aimed to explore the role of OSRE involved an OS scenario assess their potential contribution carcinogenesis some most prevalent types. Through data mining bioinformatic analysis gene protein expression mutation data, we identified with altered mutations across Functional pathways EGFR, MT-ND, GST, PLCG2, PRDX6, SRC, JAK2 were investigated. Our findings reveal traditionally considered peripheral significant tumor Those contribute initiation progression, well be hallmarks, EMT invasion, proliferation, ROS production. In addition, like SRC found dual both promoting generation being modulated OS. also interact oncogenic signaling pathways, including Wnt/β-catenin JAK2/STAT3, linking them aggressiveness therapeutic resistance. Future research should focus on translating these into clinical applications, development novel inhibitors or drugs targeting enzymes.

Language: Английский

Citations

1