Comprehensive review and in silico analysis of the role of noncoding RNAs in retinoblastoma: A step-TowarRNA precision DOI
Nadia Μ. Hamdy,

Bassant Mohamed Barakat,

Mona G. El-Sisi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144036 - 144036

Published: May 1, 2025

Language: Английский

LncRNA-miRNA-mRNA regulatory axes as potential biomarkers in cervical cancer: a comprehensive overview DOI
Dimple Patel, Sanu Thankachan,

Saraswathy Sreeram

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 8, 2025

Language: Английский

Citations

0
Advanced strategies for screening and identifying RNA-targeted small molecules: Bridging therapeutic potential and innovation DOI Creative Commons

Zukela Ruzi,

Daxiong Han,

Kailibinuer Aierken

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102305 - 102305

Published: April 1, 2025

Language: Английский

Citations

0
Epigenetic Reprogramming by Decitabine in Retinoblastoma DOI Creative Commons
Lisa Gherardini, Ankush Sharma, Monia Taranta

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(4)

Published: April 25, 2025

Introduction: Retinoblastoma (Rb) is a rare cancer, yet it the most common eye tumor in children. It can occur either familial or sporadic form, with variant being more prevalent, though its downstream effects on epigenetic markers remain largely unclear. Currently, treatment for retinoblastoma typically involves aggressive chemotherapy and surgical resection. The identification of specific characteristics non-hereditary (sporadic) Rb has led to development advanced, high-throughput methods explore profile. Our previous research demonstrated that demethylating agent 5-Aza-2′-deoxycytidine (decitabine; DAC) induced cell cycle arrest apoptosis well-characterized model (WERI-Rb-1). analysis time-dependent gene expression WERI-Rb-1 cells following DAC exposure testable hypotheses further investigate impact initiation progression tumors. Methods: Gene publicly available datasets from patients’ primary tumors normal retina have been compared those found assess relevance DAC-driven genes as effect evaluated vivo, both subcutaneous xenografts orthotopic models. qPCR Methylation-Specific PCR (MSP) was performed. Results: network maps differentially expressed identified 15 hub/driver may play pivotal role genesis retinoblastoma. significant growth vivo xenograft This associated changes expression, through direct switching-on epigenetically locked indirect regulation linked genes, suggesting potential use an anti-cancer drug patients. Conclusion: There pressing need develop innovative treatments revealed effectively suppress models, offering new therapeutic approach battle this destructive disease. discovery highlights therapy reprogramming dynamics, thus preserve vision lives affected

Language: Английский

Citations

0
Comprehensive review and in silico analysis of the role of noncoding RNAs in retinoblastoma: A step-TowarRNA precision DOI
Nadia Μ. Hamdy,

Bassant Mohamed Barakat,

Mona G. El-Sisi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144036 - 144036

Published: May 1, 2025

Language: Английский

Citations

0