GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway DOI Open Access
Haoyue Ma, Ge Yang,

Di Chang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10297 - 10297

Published: Sept. 25, 2024

Cardiac remodeling, a critical process that can lead to heart failure, is primarily characterized by cardiac hypertrophy. Studies have shown transgenic mice with Gαq receptor blockade exhibit reduced hypertrophy under induced pressure overload. GQ262, novel Gαq/11 inhibitor, has demonstrated good biocompatibility and specific inhibitory effects on compared other inhibitors. However, its role in remodeling remains unclear. This study aims explore the anti-cardiac mechanisms of GQ262 both vitro vivo, providing data theoretical support for potential use treating diseases. was via transverse aortic constriction (TAC) 4 weeks H9C2 cells through phenylephrine (PE) induction, confirmed WGA H&E staining. We found improved function, inhibited protein mRNA expression markers, levels apoptosis fibrosis. Furthermore, Akt/mTOR signaling pathway activation TAC or PE, therapeutic disappearing upon addition Akt inhibitor ARQ092. These findings reveal inhibits cardiomyocyte pathway, thereby reducing fibrosis mitigating remodeling.

Language: Английский

Exosomes and non-coding RNAs: Exploring their roles in human myocardial dysfunction DOI Open Access
Magdalena Kulus,

Maryam Farzaneh,

Mohadeseh Sheykhi-Sabzehpoush

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117853 - 117853

Published: Jan. 18, 2025

Language: Английский

Citations

1
Innovations in graphene-based electrochemical biosensors in healthcare applications DOI Creative Commons

Sudenur Ozbey,

Gulsu Keles, Sevinç Kurbanoğlu

et al.

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(5)

Published: April 9, 2025

Abstract The isolation of a single atomic layer graphite, known as graphene, marked fundamental moment that transformed the field materials science. Graphene-based nanomaterials are recognized for their superior biocompatibility compared with many other types nanomaterials. Moreover, one main reasons growing interest in graphene is its potential applications emerging technologies. Its key characteristics, including high electrical conductivity, excellent intrinsic charge carrier mobility, optical transparency, substantial specific surface area, and remarkable mechanical flexibility, position it an ideal candidate solar cells touch screens. durability further establishes strong contender developing robust materials. To date, variety methods, such traditional spectroscopic techniques chromatographic approaches, have been developed detecting biomolecules, drugs, heavy metals. Electrochemical portability, selectivity, impressive sensitivity, offer considerable convenience both patients professionals point-of-care diagnostics. Recent advancements significantly improved capacity rapid accurate detection analytes trace amounts, providing benefits biosensor technology. Additionally, integration nanotechnology has markedly enhanced sensitivity selectivity electrochemical sensors, yielding results. Innovations point-of-care, lab-on-a-chip, implantable devices, wearable sensors discussed this review. Graphical abstract

Language: Английский

Citations

0
Unraveling the Cardiac Matrix: From Diabetes to Heart Failure, Exploring Pathways and Potential Medications DOI Creative Commons
Bogdan-Sorin Tudurachi, Larisa Anghel, Andreea Tudurachi

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1314 - 1314

Published: June 13, 2024

Myocardial infarction (MI) often leads to heart failure (HF) through acute or chronic maladaptive remodeling processes. This establishes coronary artery disease (CAD) and HF as significant contributors cardiovascular illness death. Therefore, treatment strategies for patients with CAD primarily focus on preventing MI lessening the impact of after an event. fibrosis, characterized by abnormal extracellular matrix (ECM) deposition, is central cardiac remodeling. Understanding these processes key identifying new targets. Recent studies highlight SGLT2 inhibitors (SGLT2i) GLP-1 receptor agonists (GLP1-RAs) favorable options in managing type 2 diabetes due their low hypoglycemic risk benefits. review explores inflammation’s role fibrosis evaluates emerging anti-diabetic medications’ effectiveness, such SGLT2i, GLP1-RAs, dipeptidyl peptidase-4 (DPP4i), post-acute MI. were analyzed identify effective medications reducing patients. By addressing areas, we can advance our understanding potential benefits post-MI improve patient outcomes individuals at HF.

Language: Английский

Citations

1
GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway DOI Open Access
Haoyue Ma, Ge Yang,

Di Chang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10297 - 10297

Published: Sept. 25, 2024

Cardiac remodeling, a critical process that can lead to heart failure, is primarily characterized by cardiac hypertrophy. Studies have shown transgenic mice with Gαq receptor blockade exhibit reduced hypertrophy under induced pressure overload. GQ262, novel Gαq/11 inhibitor, has demonstrated good biocompatibility and specific inhibitory effects on compared other inhibitors. However, its role in remodeling remains unclear. This study aims explore the anti-cardiac mechanisms of GQ262 both vitro vivo, providing data theoretical support for potential use treating diseases. was via transverse aortic constriction (TAC) 4 weeks H9C2 cells through phenylephrine (PE) induction, confirmed WGA H&E staining. We found improved function, inhibited protein mRNA expression markers, levels apoptosis fibrosis. Furthermore, Akt/mTOR signaling pathway activation TAC or PE, therapeutic disappearing upon addition Akt inhibitor ARQ092. These findings reveal inhibits cardiomyocyte pathway, thereby reducing fibrosis mitigating remodeling.

Language: Английский

Citations

0