Specific small interfering RNAs (siRNAs) for targeting the metastasis, immune responses, and drug resistance of colorectal cancer cells (CRC) DOI

Harikumar Pallathadka,

Chou‐Yi Hsu, Raed Obaid Saleh

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112730 - 112730

Published: July 30, 2024

Language: Английский

Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells DOI Open Access
Peter Wai Tik Lee,

Lina Rochelle Koseki,

Takao Haitani

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1729 - 1729

Published: April 29, 2024

In hypoxic regions of malignant solid tumors, cancer cells acquire resistance to conventional therapies, such as chemotherapy and radiotherapy, causing poor prognosis in patients with cancer. It is widely recognized that some the key genes behind this are hypoxia-inducible transcription factors, e.g., factor 1 (HIF-1). Since HIF-1 activity suppressed by two representative 2-oxoglutarate-dependent dioxygenases (2-OGDDs), PHDs (prolyl-4-hydroxylases), FIH-1 (factor inhibiting 1), inactivation 2-OGDD has been associated therapy activation HIF-1. Recent studies have also revealed importance hypoxia-responsive mechanisms independent its isoforms (collectively, HIFs). article, we collate accumulated knowledge HIF-1-dependent responsible for anticancer drugs briefly discuss interplay between hypoxia responses, like EMT UPR, chemoresistance. addition, introduce a novel HIF-independent mechanism, which epigenetically mediated an acetylated histone reader protein, ATAD2, recently clarified.

Language: Английский

Citations

5
Cell death-associated lncRNAs in cancer immunopathogenesis: an exploration of molecular mechanisms and signaling pathways DOI

Safia Obaidur Rab,

Ahmed Hussein Zwamel, Enwa Felix Oghenemaro

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114439 - 114439

Published: Feb. 1, 2025

Language: Английский

Citations

0
Regulation of immune-mediated chemoresistance in cancer by lncRNAs: an in-depth review of signaling pathways DOI
Saade Abdalkareem Jasim, Farag M. A. Altalbawy, Subasini Uthirapathy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Design, Synthesis, and Crystal Structure of New C5-Substituted Pyrazolopyranopyrimidines: In Silico Studies Based on Network Pharmacology as Promising Anticancer Candidates for Lung Cancer DOI
Younesse Ait Elmachkouri, Ezaddine Irrou, Joel T. Mague

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142800 - 142800

Published: May 1, 2025

Language: Английский

Citations

0
LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review DOI

Shayan Khalilollah,

Sina Kalantari Soltanieh,

Raed Obaid Saleh

et al.

Cytokine, Journal Year: 2024, Volume and Issue: 179, P. 156585 - 156585

Published: April 4, 2024

Language: Английский

Citations

3
Specific small interfering RNAs (siRNAs) for targeting the metastasis, immune responses, and drug resistance of colorectal cancer cells (CRC) DOI

Harikumar Pallathadka,

Chou‐Yi Hsu, Raed Obaid Saleh

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112730 - 112730

Published: July 30, 2024

Language: Английский

Citations

2