PD-1/PD-L1 axis is involved in the interaction between microglial polarization and glioma

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112074 - 112074

Published: April 13, 2024

Language: Английский

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PD-L1 importance in malignancies comprehensive insights into the role of PD-L1 in malignancies: from molecular mechanisms to therapeutic opportunities

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 3, 2025

Language: Английский

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Programmed Death Ligand 1 (PD-L1) Expression in Lymphomas: State of the Art

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6447 - 6447

Published: June 11, 2024

The interaction of programmed death-1 (PD-1) on T lymphocytes with its ligands Programmed Death Ligand 1 (PD-L1) and 2 (PD-L2) tumor cells and/or tumor-associated macrophages results in inhibitory signals to the T-cell receptor pathway, consequently causing immune escape. PD-L1/PD-L2 are currently used as predictive tissue biomarkers clinical practice. Virtually PD-L1 levels expressed by associated a good response checkpoint blockade therapies targeting PD-1/PD-L1 axis. These restore antitumor releasing T-lymphocytes from effects cells. Immune have completely changed management patients solid cancers. This therapeutic strategy is less hematological malignancies, although been achieved some settings, such refractory/relapsed classic Hodgkin lymphoma primary mediastinal large B-cell lymphoma. Variable obtained diffuse lymphomas. Immunohistochemistry represents main technique for assessing expression review aims describe current knowledge various types lymphomas, focusing principal mechanisms underlying overexpression, prognostic significance practical issues concerning evaluation immunohistochemical

Language: Английский

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Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

With the goal to overcome limited treatment options and poor prognosis of glioblastoma (GBM), we have developed a PD-L1-targeting CAR T cell therapy, MC9999. In vitro experiments with MC9999 cells derived from GBM patients exhibited potent, antigen-specific cytotoxicity against autologous tumor immunosuppressive within microenvironment (TME). an orthotopic model using patient-derived brain tumor-initiating cells, intracranial delivery eradicated established tumors improved survival. Single-cell RNA sequencing indicated that activate interferon pathways, leading apoptosis. Multi-immunohistochemistry confirmed localized PD-L1 expression on TME-residing macrophages, but not in neurons or glia patient tissue. The local may be safe, effective approach for simultaneously targeting PD-L1-positive its TME strategy immune evasion enhance therapeutic potency therapy GBM.

Language: Английский

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Proteomic Profiling of Pre- and Post-Surgery Saliva of Glioblastoma Patients: A Pilot Investigation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12984 - 12984

Published: Dec. 3, 2024

Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor characterized by a high infiltration capability and recurrence rate. Early diagnosis crucial to improve the prognosis personalize therapeutic approach. This research explored, LC-MS proteomic analysis after proteolytic digestion, molecular profile of pre- post-operative saliva pools from newly diagnosed (ND) GBM patients comparing different times collection (R). CYCS, PRDX2, RAB1C, PSMB1, KLK6, TMOD3, PAI2, PLBD1, CAST, AHNAK, all involved in processes invasiveness chemo- radio-resistance, were found depict pre-surgery both ND R GBM. PADI4 CRYAB proteins, identified among most abundant proteins exclusive classified as elevated glioma, could have potential role disease biomarkers. Selected panels S100 potentially differentiate patient saliva. TPD52 IGKV3, exclusively saliva, be additionally distinctive relapse. Among pools, label-free relative quantitation showed statistically significant levels TXN, SERPINB5, FABP5, S100A11 between pools. All these higher ND_ R_T0 with respect CTRL modulation surgery or chemo-radiotherapy combined treatment, suggesting panel predictive prognostic These results highlight confirm that biofluid featured for easily accessible low collection, promising source biomarkers, showing new opportunities development targeted therapies diagnostic tools.

Language: Английский

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Pathological diagnosis of central nervous system tumours in adults: what’s new?

Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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