New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play? DOI
Chen‐Chung Lin, Brandon F. Law, Justin M. Hettick

et al.

Current Opinion in Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Purpose of review To describe recent findings diisocyanate-mediated mechanisms in allergy and toxicology by addressing the role microRNA (miR) immune responses that may contribute to development occupational asthma (OA). Recent Studies diisocyanate have traditionally focused on inflammatory patterns associated with exposures; however, recognized knowledge gaps exist regarding detailed molecular mechanism(s) pathogenesis. studies demonstrate critical endogenous microRNAs play as gene regulators maintaining homeostasis human body, pathophysiology many diseases including asthma. Given diisocyanate-OA shares pathophysiological characteristics asthma, it is likely miR-mediated are involved diisocyanate-OA. reports shown changes expression miRs exposure occupationally relevant diisocyanates, toluene (TDI) methylene diphenyl (MDI). Continued mechanistic study these lead novel biomarkers and/or provide efficacious targets for therapeutic strategies Summary The underlying heterogeneous complicated. In this review, we highlight research into roles potential regulation

Language: Английский

Discovering the role of microRNAs and exosomal microRNAs in chest and pulmonary diseases: a spotlight on chronic obstructive pulmonary disease DOI
Fuchun Nan, Bo Liu, Yao Cheng

et al.

Molecular Genetics and Genomics, Journal Year: 2024, Volume and Issue: 299(1)

Published: Nov. 11, 2024

Language: Английский

Citations

2
New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play? DOI
Chen‐Chung Lin, Brandon F. Law, Justin M. Hettick

et al.

Current Opinion in Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Purpose of review To describe recent findings diisocyanate-mediated mechanisms in allergy and toxicology by addressing the role microRNA (miR) immune responses that may contribute to development occupational asthma (OA). Recent Studies diisocyanate have traditionally focused on inflammatory patterns associated with exposures; however, recognized knowledge gaps exist regarding detailed molecular mechanism(s) pathogenesis. studies demonstrate critical endogenous microRNAs play as gene regulators maintaining homeostasis human body, pathophysiology many diseases including asthma. Given diisocyanate-OA shares pathophysiological characteristics asthma, it is likely miR-mediated are involved diisocyanate-OA. reports shown changes expression miRs exposure occupationally relevant diisocyanates, toluene (TDI) methylene diphenyl (MDI). Continued mechanistic study these lead novel biomarkers and/or provide efficacious targets for therapeutic strategies Summary The underlying heterogeneous complicated. In this review, we highlight research into roles potential regulation

Language: Английский

Citations

0