International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3945 - 3945

Published: April 2, 2024

Glypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact GPC4 on cancer progression through functional genomics transcriptomic analyses across a broad range Survival analysis using TCGA patient data reveals divergent effects expression types, revealing elevated levels be associated with both poor favorable prognoses cancer-dependent manner. Detailed investigation role glioblastoma non-small cell lung adenocarcinoma by genetic perturbation studies displays opposing these cancers, where knockout CRISPR/Cas9 attenuated proliferation augmented cells overexpression exhibited significant opposite effect. Further, GPC4-knocked-down restored proliferation, indicating its mitogenic effect this type. Additionally, survival substantiated findings, an association between prognosis glioblastoma, while outcome carcinoma patients. Finally, analysis, attempted assign mechanisms action GPC4, as find it implicated cycle control core pathways. The revealed upregulation oncogenes, including FGF5, TGF-β superfamily members, ITGA-5 which were downregulated Our findings illuminate pleiotropic cancer, underscoring potential putative prognostic biomarker implications type dependent

Language: Английский