Pollutants, microbiota and immune system: frenemies within the gut

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 10, 2024

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.

Language: Английский

---

Early-Life Antibiotic Exposures: Paving the Pathway for Dysbiosis-Induced Disorders

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177298 - 177298

Published: Jan. 1, 2025

Language: Английский

---

Could Environmental Exposure and Climate Change Be a Key Factor in the Rising Incidence of Early Onset Colorectal Cancer?

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35935 - e35935

Published: Aug. 1, 2024

The emergence of early onset colorectal cancer (EOCRC) is believed to result from the complex interplay between external environmental factors and internal molecular processes. This review investigates potential association exposure chemicals climate change increased incidence EOCRC, focusing on their effects gut microbiota (GM) dynamics. manuscript explores birth cohort effect, suggesting that individuals born after 1950 may be at higher risk developing EOCRC due cumulative exposures. Furthermore, we also reviewed impact pollution, including particulate matter endocrine disrupting (EDCs), as well global warming, GM disturbance. Environmental exposures have disrupt composition diversity, leading dysbiosis, chronic inflammation, oxidative stress, which are known associated with EOCRC. Particulate can enter gastrointestinal tract, modifying promoting proliferation pathogenic bacteria while diminishing beneficial bacteria. Similarly, EDCs, induce alterations further increasing Additionally, warming influence through shifts in conditions, affecting host's immune response potentially risk. To summarize, since has been implicated contributing rising Disruptions homeostasis play a crucial role mediating these associations. Consequently, there pressing need for enhanced policies aimed minimizing pollutants, safeguarding public health, mitigating burden

Language: Английский

---

Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring?

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1628 - 1628

Published: July 23, 2024

Endocrine-disrupting chemicals (EDCs) have become so pervasive in our environment and daily lives that it is impossible to avoid contact with such compounds, including pregnant women seeking minimize exposures themselves their unborn children. Developmental exposure of humans rodent models bisphenol A (BPA) other EDCs linked increased anxiogenic behaviors, learning memory deficits, decreased socio-sexual behaviors. Prenatal BPA leads longstanding harmful effects on gut microbiota reductions beneficial bacteria, i.e., dysbiosis, microbial changes are host fecal metabolites, those involved carbohydrate metabolism synthesis, neurobehavioral alterations adulthood, particular, social cognitive deficits. Gut dysbiosis increasingly being recognized as a key driver myriad diseases, ranging from metabolic, cardiovascular, reproductive, disorders via the gut-microbiome-brain axis. Thus, might induce indirect physical mental health by acting microbiome-disrupting chemicals. Findings raise important question whether should consume probiotic supplement mitigate pernicious EDCs, especially BPA, offspring. Current studies investigating maternal supplementation women's offspring will be reviewed. Data inform potential application reverse unwittingly exposed these compounds striving give best start life.

Language: Английский

---

Dietary interventions in mitigating the impact of environmental pollutants on Alzheimer’s disease – A review

Neuroscience, Journal Year: 2024, Volume and Issue: 563, P. 148 - 166

Published: Nov. 13, 2024

Language: Английский

---